Patents by Inventor Brandon Seal

Brandon Seal has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and methods for delivery of kinase inhibiting peptides
    Patent number: 10034839
    Abstract: The invention relates to compositions and methods for the treatment of inflammatory disease states. In particular, the invention relates to the use of a nanoparticle incorporated kinase inhibiting peptide to treat inflammatory disease states.
    Type: Grant
    Filed: August 10, 2016
    Date of Patent: July 31, 2018
    Assignee: Purdue Research Foundation
    Inventors: Alyssa Panitch, Brandon Seal, Jamie L. Brugnano, Rush L. Bartlett, Shaili Sharma, James McMasters
  • Polypeptide inhibitors of HSP27 kinase and uses therfor
    Patent number: 9649354
    Abstract: The present invention provides polypeptide inhibitors of HSP27 kinase, compositions thereof, and methods for using such polypeptides and compositions for various therapeutic uses.
    Type: Grant
    Filed: September 29, 2016
    Date of Patent: May 16, 2017
    Assignee: Purdue Research Foundation
    Inventors: Alyssa Panitch, Brandon Seal, Brian P. Ward
  • POLYPEPTIDE INHIBITORS OF HSP27 KINASE AND USES THERFOR
    Publication number: 20170072009
    Abstract: The present invention provides polypeptide inhibitors of HSP27 kinase, compositions thereof, and methods for using such polypeptides and compositions for various therapeutic uses.
    Type: Application
    Filed: September 29, 2016
    Publication date: March 16, 2017
    Inventors: Alyssa Panitch, Brandon Seal, Brian P. Ward
  • COMPOSITIONS AND METHODS FOR DELIVERY OF KINASE INHIBITING PEPTIDES
    Publication number: 20170035702
    Abstract: The invention relates to compositions and methods for the treatment of inflammatory disease states. In particular, the invention relates to the use of a nanoparticle incorporated kinase inhibiting peptide to treat inflammatory disease states.
    Type: Application
    Filed: August 10, 2016
    Publication date: February 9, 2017
    Inventors: Alyssa Panitch, Brandon Seal, Jamie L. Brugnano, Rush L. Bartlett, Shaili Sharma, James McMasters
  • Polypeptide inhibitors of HSP27 kinase and uses therefor
    Patent number: 9493508
    Abstract: The present invention provides polypeptide inhibitors of HSP27 kinase, compositions thereof, and methods for using such polypeptides and compositions for various therapeutic uses.
    Type: Grant
    Filed: July 3, 2013
    Date of Patent: November 15, 2016
    Assignee: Purdue Research Foundation
    Inventors: Alyssa Panitch, Brandon Seal, Brian C. Ward
  • Compositions and methods for delivery of kinase inhibiting peptides
    Patent number: 9452218
    Abstract: The invention relates to compositions and methods for the treatment of inflammatory disease states. In particular, the invention relates to the use of a nanoparticle incorporated kinase inhibiting peptide to treat inflammatory disease states.
    Type: Grant
    Filed: March 8, 2013
    Date of Patent: September 27, 2016
    Assignee: Purdue Research Foundation
    Inventors: Alyssa Panitch, Brandon Seal, Jamie L. Brugnano, Rush L. Bartlett, Shaili Sharma, James McMasters
  • Kinase inhibitors and uses thereof
    Patent number: 9447158
    Abstract: The present invention relates to kinase inhibiting compositions and uses thereof. The invention further provides isolated kinase inhibiting peptides and uses thereof for inhibiting hyperplasia, for inhibiting the growth of neoplasms, and for inducing programmed cell death in a cell population.
    Type: Grant
    Filed: April 22, 2014
    Date of Patent: September 20, 2016
    Assignee: Purdue Research Foundation
    Inventors: Alyssa Panitch, Brandon Seal, Brian Ward
  • Cell-permeant peptide-based inhibitor of kinases
    Patent number: 9327008
    Abstract: The described invention provides kinase inhibiting compositions containing a therapeutic amount of a therapeutic inhibitor peptide that inhibits at least one kinase enzyme, methods for treating an inflammatory disorder whose pathophysiology comprises inflammatory cytokine expression, and methods for treating an inflammatory disorder whose pathophysiology comprises inflammatory cytokine expression using the kinase inhibiting compositions.
    Type: Grant
    Filed: December 9, 2009
    Date of Patent: May 3, 2016
    Assignee: Purdue Research Foundation
    Inventors: Alyssa Panitch, Brandon Seal
  • COMPOSITIONS AND METHODS FOR DELIVERY OF KINASE INHIBITING PEPTIDES
    Publication number: 20150018279
    Abstract: The invention relates to compositions and methods for the treatment of inflammatory disease states. In particular, the invention relates to the use of a nanoparticle incorporated kinase inhibiting peptide to treat inflammatory disease states.
    Type: Application
    Filed: March 8, 2013
    Publication date: January 15, 2015
    Inventors: Alyssa Panitch, Brandon Seal, Jamie L. Brugnano, Rush L. Bartlett, Shaili Sharma, James Mcmasters
  • KINASE INHIBITORS AND USES THEREOF
    Publication number: 20140342993
    Abstract: The present invention relates to kinase inhibiting compositions and uses thereof. The invention further provides isolated kinase inhibiting peptides and uses thereof for inhibiting hyperplasia, for inhibiting the growth of neoplasms, and for inducing programmed cell death in a cell population.
    Type: Application
    Filed: April 22, 2014
    Publication date: November 20, 2014
    Applicant: PURDUE RESEARCH FOUNDATION
    Inventors: Alyssa PANITCH, Brandon SEAL, Brian WARD
  • Kinase inhibitors and uses thereof
    Patent number: 8741849
    Abstract: The present invention relates to kinase inhibiting compositions and uses thereof. The invention further provides isolated kinase inhibiting peptides and uses thereof for inhibiting hyperplasia, for inhibiting the growth of neoplasms, and for inducing programmed cell death in a cell population.
    Type: Grant
    Filed: August 7, 2008
    Date of Patent: June 3, 2014
    Assignee: Purdue Research Foundation
    Inventors: Alyssa Panitch, Brandon Seal, Brian Ward
  • Polypeptide Inhibitors of HSP27 Kinase and Uses Therefor
    Publication number: 20140112947
    Abstract: The present invention provides polypeptide inhibitors of HSP27 kinase, compositions thereof, and methods for using such polypeptides and compositions for various therapeutic uses.
    Type: Application
    Filed: July 3, 2013
    Publication date: April 24, 2014
    Inventors: Alyssa Panitch, Brandon Seal, Brian P. Ward
  • Polypeptide inhibitors of HSP27 kinase and uses therefor
    Patent number: 8536303
    Abstract: The present invention provides polypeptide inhibitors of HSP27 kinase, compositions thereof, and methods for using such polypeptides and compositions for various therapeutic uses.
    Type: Grant
    Filed: January 10, 2008
    Date of Patent: September 17, 2013
    Assignee: Purdue Research Foundation
    Inventors: Alyssa Panitch, Brandon Seal, Brian Ward
  • Kinase Inhibitors And Uses Thereof
    Publication number: 20130184221
    Abstract: The present invention relates to kinase inhibiting compositions and uses thereof. The invention further provides isolated kinase inhibiting peptides and uses thereof for inhibiting hyperplasia, for inhibiting the growth of neoplasms, and for inducing programmed cell death in a cell population.
    Type: Application
    Filed: August 7, 2008
    Publication date: July 18, 2013
    Applicant: Purdue Research Foundation
    Inventors: Alyssa Panitch, Brandon Seal
  • METHODS FOR TREATING OR PREVENTING VASCULAR GRAFT FAILURE
    Publication number: 20130115256
    Abstract: The described invention provides pharmaceutical compositions and methods for treating or preventing vascular graft failure in a subject in need of such treatment, the method comprising administering a therapeutically effective amount of a composition comprising a polypeptide of amino acid sequence YARAAARQARAKALARQLGVAA (SEQ ID NO: 1) or a functional equivalent thereof, and a pharmaceutically acceptable carrier. The methods also are clinically useful for treating a pre-atherosclerotic intimal hyperplasia condition.
    Type: Application
    Filed: May 24, 2011
    Publication date: May 9, 2013
    Inventors: Cynthia Lander, Alyssa Panitch, Colleen Brophy, Brandon Seal
  • Reagents and methods for smooth muscle therapies
    Patent number: 8129332
    Abstract: The present invention provides novel polypeptides comprising heat shock protein 20 (HSP20)-derived polypeptides to treat or inhibit smooth muscle vasospasm, as well to treat and inhibit smooth muscle cell proliferation and migration.
    Type: Grant
    Filed: April 11, 2008
    Date of Patent: March 6, 2012
    Assignee: Arizona Board of Regents
    Inventors: Colleen Brophy, Alyssa Panitch, Padmini Komalavilas, Brandon Seal, Lokesh Joshi
  • Methods for Treating or Preventing Vascular Graft Failure
    Publication number: 20110288036
    Abstract: The described invention provides pharmaceutical compositions and methods for treating or preventing vascular graft failure in a subject in need of such treatment, the method comprising administering a therapeutically effective amount of a composition comprising a polypeptide of amino acid sequence YARAAARQARAKALARQLGVAA (SEQ ID NO: 1) or a functional equivalent thereof, and a pharmaceutically acceptable carrier. The methods also are clinically useful for treating a pre-atherosclerotic intimal hyperplasia condition.
    Type: Application
    Filed: May 24, 2011
    Publication date: November 24, 2011
    Inventors: Cynthia Lander, Colleen Brophy, Brandon Seal
  • Reagents and methods for smooth muscle therapies
    Patent number: 8044018
    Abstract: The present invention provides novel polypeptides comprising heat shock protein 20 (HSP20)-derived polypeptides to treat or inhibit smooth muscle vasospasm, as well to treat and inhibit smooth muscle cell proliferation and migration.
    Type: Grant
    Filed: April 11, 2008
    Date of Patent: October 25, 2011
    Assignee: Arizona Board of Regents
    Inventors: Colleen Brophy, Alyssa Panitch, Padmini Komalavilas, Brandon Seal, Lokesh Joshi
  • CELL-PERMEANT PEPTIDE-BASED INHIBITOR OF KINASES
    Publication number: 20100158968
    Abstract: The described invention provides kinase inhibiting compositions containing a therapeutic amount of a therapeutic inhibitor peptide that inhibits at least one kinase enzyme, methods for treating an inflammatory disorder whose pathophysiology comprises inflammatory cytokine expression, and methods for treating an inflammatory disorder whose pathophysiology comprises inflammatory cytokine expression using the kinase inhibiting compositions.
    Type: Application
    Filed: December 9, 2009
    Publication date: June 24, 2010
    Inventors: Alyssa Panitch, Brandon Seal
  • Novel Protein Transduction Domains and Uses Therefor
    Publication number: 20100004165
    Abstract: The present invention provides novel transduction domains, compositions comprising such transduction domains, and their use for in vivo molecular delivery.
    Type: Application
    Filed: October 30, 2006
    Publication date: January 7, 2010
    Applicant: The Arizona Board of Regents, a body corporate acting on behalf of Arizona State University
    Inventors: Colleen Brophy, Alyssa Panitch, Elizabeth Furnish, Brandon Seal