Abstract: Disclosed are compounds of Formula (I), methods of using the compounds for inhibiting KRAS activity and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders associated with KRAS activity such as cancer.

Abstract: Generally disclosed herein is an approach for enhancing the music delivery system and service by extracting application-specific stems from standard pre-mixed music content. The approach also includes analyzing the pre-mixed music content and generating metadata based on the analyzed pre-mixed music content. The approach further includes distributing the metadata with the original music content to a user device. The approach also includes post-processing the original music content using the metadata for various applications.

Abstract: High-accuracy locating systems and methods are used for determining successful caregiver rounding, monitoring whether housekeepers have properly cleaned patient beds, or determining whether patients have ambulated sufficient distances during recovery. Patient beds having at least two locating tags are used for establishing patient care zones around the patient beds. Locating anchors and equipment tags are moved around a patient room to determine optimum locating anchor placement within the patient room based on signal quality values. A locating tag on a patient bed switches roles to operate as a locating anchor in response to the patient bed becoming stationary. A locating tag has a digital compass which is used to determine a field of good ranging relative to a front of a caregiver wearing the locating tag.

Abstract: High-accuracy locating systems and methods are used for determining successful caregiver rounding, monitoring whether housekeepers have properly cleaned patient beds, or determining whether patients have ambulated sufficient distances during recovery. Patient beds having at least two locating tags are used for establishing patient care zones around the patient beds. Locating anchors and equipment tags are moved around a patient room to determine optimum locating anchor placement within the patient room based on signal quality values. A locating tag on a patient bed switches roles to operate as a locating anchor in response to the patient bed becoming stationary. A locating tag has a digital compass which is used to determine a field of good ranging relative to a front of a caregiver wearing the locating tag.

Abstract: Various methods and systems are provided for integrated filter assemblies including a bowtie filter and a hardening filter mounted on a single carriage. In one embodiment, an imaging system may include an x-ray source to generate an x-ray beam, a pre-patient collimator positioned adjacent to the x-ray source such that the x-ray beam passes through the pre-patient collimator. The pre-patient collimator includes a carriage, and at least one filter coupled to one edge of the carriage and extending away from the carriage.

Abstract: A system may include a platform proximate to an operator cab of the vehicle. A system may include a staircase, the staircase selectively moveable between a retracted state and an extended state, the staircase including a plurality of steps including a retractable step, at least one support segment coupling together the steps of the plurality of steps, a first inclination angle and a first step angle in the retracted state, a second inclination angle and a second step angle in the extended state, wherein the first inclination angle is steeper than the second inclination angle and the first step angle is larger than the second step angle. A system may include a linkage system coupling the staircase to the platform, the linkage system including an actuator configured to selectively move the staircase from the retracted state to the extended state; and a moveable extension bracket coupling the staircase to the platform.

Abstract: A device includes a platform and a staircase moveable between a retracted state and an extended state. The staircase has steps including a retractable step and a support segment. A linkage system includes an actuator that moves the staircase from the retracted and extended state, a sensor detecting the staircase state and a vehicle condition, and an extension bracket coupling the staircase and platform. A controller determines the staircase state, determines an articulation angle, compares the articulation angle to an articulation angle threshold, in response to the articulation angle exceeding the threshold, causes the staircase to move to the retracted state, detects a vehicle operation event, in response to detecting the operation event, causes the staircase to move to the retracted state, detects a vehicle shut-down event, and in response to detecting the shut-down event causes the staircase to move to the extended state.

Abstract: The present application provides imidazolyl pyrimidinylamine inhibitors of cyclin-dependent kinase 2 (CDK2), as well as pharmaceutical compositions thereof, and methods of treating cancer using the same.

Abstract: Various systems and methods are provided for an integrated filter assembly including at least one bowtie filter and at least one beam hardening filter mounted on a carriage. In one embodiment, an imaging system may include a first carriage including at least one beam hardening filter and at least one bowtie filter, a second carriage including at least two additional bowtie filters, and a carriage driving system for moving the carriages to selectively position the at least one beam hardening filter and one of the bowtie filters in a path of an X-ray beam. The at least one beam hardening filter may overlap with at least one of the bowtie filters.

Abstract: The present application provides imidazolyl pyrimidinylamine inhibitors of cyclin-dependent kinase 2 (CDK2), as well as pharmaceutical compositions thereof, and methods of treating cancer using the same.

Abstract: Disclosed are compounds of Formula (I), methods of using the compounds for inhibiting KRAS activity and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders associated with KRAS activity such as cancer.

Abstract: Methods and systems for using machine learning systems to create models that define a first tier of initial event case users and user accounts, a second tier of users and user accounts that are interaction counterparties of first tier user accounts, and a third tier of users and user accounts that are interaction counterparties of second tier customer accounts. The processor may then identify first and second tier users and user accounts affiliated with an a fraudulent case history and may classify each first tier user according to risk based on interaction counterparty account links to various second tier users or links to various third tier users via interaction counterparty account links between second and third tier users.

Abstract: Embodiments of systems and methods for user enrollment in speaker authentication and speaker identification systems are disclosed. In some embodiments, the enrollment process includes collecting speech samples that are examples of multiple speech types spoken by a user, computing a speech representation for each speech sample, and aggregating the example speech representations to form a robust overall representation or user voiceprint of the user's speech.

Abstract: Various systems and methods are provided for an integrated filter assembly including at least one bowtie filter and at least one beam hardening filter mounted on a carriage. In one embodiment, an imaging system may include a first carriage including at least one beam hardening filter and at least one bowtie filter, a second carriage including at least two additional bowtie filters, and a carriage driving system for moving the carriages to selectively position the at least one beam hardening filter and one of the bowtie filters in a path of an X-ray beam. The at least one beam hardening filter may overlap with at least one of the bowtie filters.

Abstract: High-accuracy locating systems and methods are used for determining successful caregiver rounding, monitoring whether housekeepers have properly cleaned patient beds, or determining whether patients have ambulated sufficient distances during recovery. Patient beds having at least two locating tags are used for establishing patient care zones around the patient beds. Locating anchors and equipment tags are moved around a patient room to determine optimum locating anchor placement within the patient room based on signal quality values. A locating tag on a patient bed switches roles to operate as a locating anchor in response to the patient bed becoming stationary. A locating tag has a digital compass which is used to determine a field of good ranging relative to a front of a caregiver wearing the locating tag.

Abstract: High-accuracy locating systems and methods are used for determining successful caregiver rounding, monitoring whether housekeepers have properly cleaned patient beds, or determining whether patients have ambulated sufficient distances during recovery. Patient beds having at least two locating tags are used for establishing patient care zones around the patient beds. Locating anchors and equipment tags are moved around a patient room to determine optimum locating anchor placement within the patient room based on signal quality values. A locating tag on a patient bed switches roles to operate as a locating anchor in response to the patient bed becoming stationary. A locating tag has a digital compass which is used to determine a field of good ranging relative to a front of a caregiver wearing the locating tag.

Abstract: The present application provides imidazolyl pyrimidinylamine inhibitors of cyclin-dependent kinase 2 (CDK2), as well as pharmaceutical compositions thereof, and methods of treating cancer using the same.

Abstract: The present application provides imidazolyl pyrimidinylamine inhibitors of cyclin-dependent kinase 2 (CDK2), as well as pharmaceutical compositions thereof, and methods of treating cancer using the same.