Abstract: The present disclosure provides systems and methods for brain source localization. In particular, the present disclosure provides a novel source reconstruction method (termed “TEmporally Dependent Iterative Expansion” or TEDIE), that accurately reconstructs propagating and expanding neural sources over time. The systems and method described herein can be used as a clinical tool to enhance epileptogenic zone localization and improve surgical outcomes.

Abstract: A system for delivering neurostimulation to a patient may include a pattern optimization circuit and a programming control circuit. The pattern optimization circuit may receive an objective function, a model, and one or more patterns of neurostimulation each including multiple stimulation parameters and may include optimization processing circuitry configured to determine an optimal pattern of neurostimulation using a simulation with the objective function, the model, and the one or more patterns of neurostimulation. The optimal pattern of neurostimulation including first stimulation parameter(s) each identified by the simulation to have a fixed value or value range with which a sensitivity to values of each of second stimulation parameter(s) on the objective function is identified by the simulation to be minimized.

Abstract: A neurostimulation system may include at least one electrode contact and a neurostimulator configured to use the at least one electrode contact to deliver a stimulation therapy to a patient using an electrical waveform that includes first phases of a first polarity and second phases of a second polarity opposite the first polarity. The neurostimulator may configured to deliver the stimulation therapy by therapeutically stimulating neural tissue using the both the first phases and the second phases of the electrical waveform. The second phases remove built up charge from the at least one electrode contact caused by the first phases, and the first phases remove built up charge from the at least one electrode contact caused by the second phases. Benefits include reducing energy consumption using the recharge pulse to activate a population of neural elements for reducing energy consumption.

Abstract: The present disclosure describes innovations to improve the use of stereo-EEG (sEEG) intreating epilepsy. The systems and methods include a fully automated platform for generating patient specific head models, a visualization of the tissue that can be recorded by a set of sEEG electrodes, an automated implantation trajectory planning algorithm that incorporates the tissue that can be recorded by a set of sEEG electrodes, and a dynamic source reconstruction algorithm that can visualize the epileptiform activity.

Abstract: A system may include a neuromodulator and a programmer configured to program the neuromodulator to deliver neuromodulation according to a modulated neurostimulation parameter setting. The modulated neurostimulation parameter setting may include a first modulated neurostimulation parameter waveform and a second modulated neurostimulation parameter waveform, and a phase offset between the first and the second modulated neurostimulation parameter waveforms.