Patents by Inventor Brandon W. LEVEILLE

Brandon W. LEVEILLE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • LYOPHILIZED FACTOR IX FORMULATIONS
    Publication number: 20210069307
    Abstract: The present invention provides, among other things, pre-lyophilization formulations, reconstituted formulations, and lyophilate powder compositions comprising a Factor IX (FIX) polypeptide. The present invention also provides lyophilization methods for producing lyophilate powder comprising a FIX polypeptide.
    Type: Application
    Filed: August 17, 2020
    Publication date: March 11, 2021
    Inventors: Brian M. THOME, Cherie PARKHURST-LANG, Brandon W. LEVEILLE
  • Lyophilized factor IX formulations
    Patent number: 10772942
    Abstract: The present invention provides, among other things, pre-lyophilization formulations, reconstituted formulations, and lyophilate powder compositions comprising a Factor IX (FIX) polypeptide. The present invention also provides lyophilization methods for producing lyophilate powder comprising a FIX polypeptide. The present invention is directed to a pre-lyophilization formulation comprising: (a) a Factor IX (FIX) polypeptide having FIX coagulation activity; (b) a buffering agent; (c) a stabilizing agent; (d) a bulking agent; and (e) a surfactant, wherein the formulation has a fill volume of less than about 5 mL, and wherein each of (a)-(e) are at an amount per vial (mg/vial) sufficient to allow (1) improved stability of the FIX polypeptide when lyophilized.
    Type: Grant
    Filed: March 24, 2015
    Date of Patent: September 15, 2020
    Assignee: Bioverativ Therapeutics Inc.
    Inventors: Brian M. Thome, Cherie Parkhurst-Lang, Brandon W. Leveille
  • Lyophilized Factor IX Formulations
    Publication number: 20170173122
    Abstract: The present invention provides, among other things, pre-lyophilization formulations, reconstituted formulations, and lyophilate powder compositions comprising a Factor IX (FIX) polypeptide. The present invention also provides lyophilization methods for producing lyophilate powder comprising a FIX polypeptide. The present invention is directed to a pre-lyophilization formulation comprising: (a) a Factor IX (FIX) polypeptide having FIX coagulation activity; (b) a buffering agent; (c) a stabilizing agent; (d) a bulking agent; and (e) a surfactant, wherein the formulation has a fill volume of less than about 5 mL,and wherein each of (a)-(e) are at an amount per vial (mg/vial) Empty Vials sufficient to allow (1) improved stability of the FIX polypeptide when lyophilized.
    Type: Application
    Filed: March 24, 2015
    Publication date: June 22, 2017
    Inventors: Brian M. THOME, Cherie PARKHURST-LANG, Brandon W. LEVEILLE