Patents by Inventor Branislav Kováce{hacek over (c)}h

Branislav Kováce{hacek over (c)}h has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Protein-based therapy and diagnosis of tau-mediated pathology in Alzheimer's disease
    Patent number: 9845352
    Abstract: The invention provides unique therapeutic and diagnostic antibodies, as well as their fragments, portions, derivatives, and variants thereof, that bind regions of the tau protein that contribute to the initiation and propagation of pathological tau-tau interactions, as well as methods of making them. The invention also relates to methods of using those antibodies for diagnostics, prevention, and treatment of Alzheimer's disease and related tauopathies. The present invention also provides a method for a prophylactic and therapeutic treatment of Alzheimer's disease and other neurodegenerative tauopathies. This method entails the injection of antibodies and/or peptide vaccines that elicits an immune response directed to pathological tau proteins and tau deposits in the brains of patients. Suitable vaccines represent a tau peptide carrying one or more of the tau therapeutic epitopes provided herein.
    Type: Grant
    Filed: May 19, 2017
    Date of Patent: December 19, 2017
    Assignee: AXON NEUROSCIENCE SE
    Inventors: Michal Novák, Eva Kontseková, Branislav Kováce{hacek over (c)}h, Norbert {hacek over (Z)}ilka
  • Protein-based therapy and diagnosis of tau-mediated pathology in Alzheimer's disease
    Patent number: 9828421
    Abstract: The invention provides unique therapeutic and diagnostic antibodies, as well as their fragments, portions, derivatives, and variants thereof, that bind regions of the tau protein that contribute to the initiation and propagation of pathological tau-tau interactions, as well as methods of making them. The invention also relates to methods of using those antibodies for diagnostics, prevention, and treatment of Alzheimer's disease and related tauopathies. The present invention also provides a method for a prophylactic and therapeutic treatment of Alzheimer's disease and other neurodegenerative tauopathies. This method entails the injection of antibodies and/or peptide vaccines that elicits an immune response directed to pathological tau proteins and tau deposits in the brains of patients. Suitable vaccines represent a tau peptide carrying one or more of the tau therapeutic epitopes provided herein.
    Type: Grant
    Filed: November 3, 2016
    Date of Patent: November 28, 2017
    Assignee: Axon Neuroscience SE
    Inventors: Michal Novák, Eva Kontseková, Branislav Kováce{hacek over (c)}h, Norbert {hacek over (Z)}ilka