Abstract: Kolmogorov-Arnold analysis is invented as a tool for the study of tumor and normal coding in human genomics sequencing to identify tumor-specific (somatic) sequences and copy number alterations. The technique enables to reveal quantitatively somatic sequences in the dataset of the genomic DNA purified from tumor and normal specimens. The computer power requirements for an analysis are modest ones.

Abstract: Kolmogorov-Arnold analysis is invented as a tool for the study of tumor and normal coding in human genomics sequencing to identify tumor-specific (somatic) sequences and copy number alterations. The technique enables to reveal quantitatively somatic sequences in the dataset of the genomic DNA purified from tumor and normal specimens. The computer power requirements for an analysis are modest ones.

Abstract: The invention describes methods that use nanostructures and quantum confinement to detect and manipulate chemical and biochemical molecules. To increase selectivity and sensitivity nanostructures are built to have the density of states similar to that in analyte that will be detected and operated. Using device that incorporates such nanostructures, measuring electrical and optical properties of nanostructures and analyte or charge and energy transfer between the nanostructures and analyte a rapid and sensitive continuous detection in fluids can be achieved. Detection can be further enhanced by controlling external environmental parameters and applying external fields. In addition to be detected analyte can be positioned, moved, separated, extracted, and controlled.

Abstract: The invention describes methods that use nanostructures and quantum confinement to detect and manipulate chemical and biochemical molecules. To increase selectivity and sensitivity nanostructures are built to have the density of states similar to that in analyte that will be detected and operated. Using device that incorporates such nanostructures, measuring electrical and optical properties of nanostructures and analyte or charge and energy transfer between the nanostructures and analyte a rapid and sensitive continuous detection in fluids can be achieved. Detection can be further enhanced by controlling external environmental parameters and applying external fields. In addition to be detected analyte can be positioned, moved, separated, extracted, and controlled.

Abstract: The invention describes a detection device that comprise nanostructures and which detection mechanism is based on the quantum confinement effects. The analyte species are sensed by measuring charge or/and energy transfer between the species and the nanostructures, which will be proportional to the overlap between the density of states distribution in the nanostructures and the density of states distribution in the targeted analyte species.

Abstract: The invention describes detection methods and devices that comprise nanostructures and which detection mechanism is based on the quantum confinement effects. The nanostructures are built to have specific energy levels designed to match the energy levels of the targeted analyte that is to be detected. The analyte species are sensed by measuring charge or/and energy transfer between the species and the nanostructures, which will be proportional to the overlap between the density of states distribution in the nanostructures and the density of states distribution in the targeted analyte species. Different molecular species have different electronic density of states, so the charge or/and energy transfer between the targeted analyte and detector nanostructures will occur only for specific analyte which has the same electronic density of states as the detectors nanostructure.