Patents by Inventor Brant Clayton Boren

Brant Clayton Boren has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS OF MAKING WEE1 INHIBITOR COMPOUNDS
    Publication number: 20230234956
    Abstract: A process is provided for making a WEE1 inhibitor of the formula (1A) useful in the treatment of conditions characterized by excessive cellular proliferation, such as cancer. In some embodiments, processes are provided for making intermediate compounds of the formulae (3), (5) and (6) as defined herein.
    Type: Application
    Filed: June 9, 2021
    Publication date: July 27, 2023
    Inventors: Peter Qinhua Huang, Chad Daniel Hopkins, Brant Clayton Boren, Sunny Abraham, Kevin Duane Bunker, Sobhana Babu Boga, Shuguang Zhu, Tao Wu, Benjamin Pratt
  • MONO- AND COMBINATION THERAPIES
    Publication number: 20230210854
    Abstract: Disclosed herein are compounds and combinations of compounds for treating a disease or condition, such as cancer.
    Type: Application
    Filed: May 12, 2021
    Publication date: July 6, 2023
    Inventors: Ahmed Abdi Samatar, Jiali Li, Peter Qinhua Huang, Kevin Duane Bunker, Fernando Donate, Brant Clayton Boren
  • MACROCYCLIC COMPOUNDS
    Publication number: 20230192720
    Abstract: The present application discloses compounds of Formula (I). Such compounds, pharmaceutically acceptable salts and compositions thereof, are inhibitors of Mcl-1 proteins and are useful in treating diseases and conditions characterized by excessive cellular proliferation such as cancer.
    Type: Application
    Filed: August 6, 2020
    Publication date: June 22, 2023
    Inventors: Junhu Zhang, Peter Qinhua Huang, Kevin Duane Bunker, Sobhana Babu Boga, Sunny Abraham, Brant Clayton Boren, Wanlong Jiang, Sunil Paliwal
  • COMBINATIONS
    Publication number: 20230087941
    Abstract: Disclosed herein are combinations of compounds for treating a disease or condition, such as cancer. A combination of compounds for treating a disease or condition can include a SERD inhibitor and a WEE1 inhibitor, along with pharmaceutically acceptable salts of any of the foregoing.
    Type: Application
    Filed: December 16, 2020
    Publication date: March 23, 2023
    Inventors: Ahmed Abdi Samatar, Jiali Li, Jianhui Ma, Peter Qinhua Huang, Sayee Gajanan Hegde, Brant Clayton Boren, Kevin Duane Bunker, Fernando Donate
  • COMBINATIONS
    Publication number: 20230068370
    Abstract: Disclosed herein are combinations of compounds for treating a disease or condition, such as cancer. A combination of compounds for treating a disease or condition can include a WEE1 inhibitor, and a SERD or SERM inhibitor, along with pharmaceutically acceptable salts of any of the foregoing.
    Type: Application
    Filed: December 16, 2020
    Publication date: March 2, 2023
    Inventors: Ahmed Abdi Samatar, Jiali Li, Peter Qinhua Huang, Brant Clayton Boren, Kevin Duane Bunker, Fernando Donate
  • COMBINATIONS
    Publication number: 20230054854
    Abstract: Disclosed herein are combinations of compounds for treating a disease or condition, such as cancer. A combination of compounds for treating a disease or condition can include a Bcl-2 inhibitor and a WEE1 inhibitor, along with pharmaceutically acceptable salts of any of the foregoing.
    Type: Application
    Filed: December 16, 2020
    Publication date: February 23, 2023
    Inventors: Ahmed Abdi Samatar, Jiali Li, Hooman Izadi, Peter Qinhua Huang, Joseph Robert Pinchman, Brant Clayton Boren, Kevin Duane Bunker, Fernando Donate
  • COMBINATIONS
    Publication number: 20230008362
    Abstract: Disclosed herein are combinations of compounds for treating a disease or condition, such as cancer. A combination of compounds for treating a disease or condition can include a WEE1 inhibitor and a Bcl-2 inhibitor, along with pharmaceutically acceptable salts of any of the foregoing.
    Type: Application
    Filed: December 16, 2020
    Publication date: January 12, 2023
    Inventors: Ahmed Abdi Samatar, Jiali Li, Hooman Izadi, Peter Qinhua Huang, Brant Clayton Boren, Joseph Robert Pinchman, Kevin Duane Bunker, Fernando Donate
  • CHIRAL SYNTHESIS OF A TERTIARY ALCOHOL
    Publication number: 20230002426
    Abstract: Disclosed herein are methods for preparing tertiary alcohols from an optionally substituted phenyl ketone or an optionally substituted pyridinyl ketone that includes the use of a chiral ligand and boron trifluoride diethyl etherate. Tertiary alcohols can be used to prepare synthetic versions of natural products and/or pharmaceuticals.
    Type: Application
    Filed: November 12, 2020
    Publication date: January 5, 2023
    Inventors: Sunny Abraham, Brant Clayton Boren, Sobhana Babu Boga, Aditya Krishnan Unni, Peter Qinhua Huang, Kevin Duane Bunker, Benjamin Anthony Pratt
  • Substituted 4-amino-5-(cyclohexyloxy)quinoline-3-carboxylic acids as sweet flavor modifiers
    Patent number: 11339128
    Abstract: Disclosed herein are 4-amino-5-(cyclohexyloxy)quinoline-3-carboxylic acid compounds having useful as sweet flavor modifiers. Also disclosed herein are ingestible compositions that include one or more of these compounds in combination with a natural or artificial sweetener.
    Type: Grant
    Filed: October 28, 2015
    Date of Patent: May 24, 2022
    Assignee: FIRMENICH INCORPORATED
    Inventors: Goran Petrovic, Joseph R. Fotsing, Guy Servant, Catherine Tachdjian, Donald Karanewsky, Binh Vong, Brant Clayton Boren, Qing Chen, Hong Zhang, Brett Weylan Ching, Stephanie Lapera
  • MACROCYCLIC COMPOUNDS
    Publication number: 20220144854
    Abstract: Disclosed are macrocyclic compounds of formula (I) comprising a 2-carboxy indole ring. Such compounds, and their pharmaceutically acceptable salts, are useful as Mcl-1 (myeloid cell leukemia-1) inhibitors. The compounds may be used in treating a disease or condition, such as cancer.
    Type: Application
    Filed: March 6, 2020
    Publication date: May 12, 2022
    Inventors: Junhu Zhang, Peter Qinhua Huang, Kevin Duane Bunker, Sobhana Babu Boga, Sunny Abraham, Brant Clayton Boren, Wanlong Jiang, Sunil Paliwal
  • Substituted 1,2-dihydro-3H-pyrazolo[3,4-D]pyrimidin-3-ones
    Patent number: 11261192
    Abstract: Compounds of Formula (I) are provided herein. Such compounds, as well as pharmaceutically acceptable salts and compositions thereof, are useful for treating diseases or conditions, including conditions characterized by excessive cellular proliferation, such as breast cancer.
    Type: Grant
    Filed: February 26, 2019
    Date of Patent: March 1, 2022
    Assignee: Recurium IP Holdings, LLC
    Inventors: Peter Qinhua Huang, Kevin Duane Bunker, Brant Clayton Boren, Sayee Gajanan Hegde, Hui Liu, Aditya Krishnan Unni, Sunny Abraham, Chad Daniel Hopkins, Sunil Paliwal
  • Analgesic compounds
    Patent number: 11242327
    Abstract: Disclosed herein are compounds of Formulae (Ia), (Ib), (Ic), (Id), (Ie), (If), (Ig), (Ih), (Ik), (Im), (In), (Io), (Ip), (Iq), (Ir), (Is) and (It), methods of synthesizing compounds of Formulae (Ia), (Ib), (Ic), (Id), (Ie), (If), (Ig), (Ih), (Ik), (Im), (In), (Io), (Ip), (Iq), (Ir), (Is) and (It), and methods of using compounds of Formulae (Ia), (Ib), (Ic), (Id), (Ie), (If), (Ig), (Ih), (Ik), (Im), (In), (Io), (Ip), (Iq), (Ir), (Is) and (It) as an analgesic.
    Type: Grant
    Filed: May 11, 2018
    Date of Patent: February 8, 2022
    Assignee: Recurium IP Holdings, LLC
    Inventors: Chad Daniel Hopkins, Joseph Robert Pinchman, Kevin Duane Bunker, Deborah Helen Slee, Brant Clayton Boren, Mehmet Kahraman
  • SUBSTITUTED 1,2-DIHYDRO-3H-PYRAZOLO[3,4-D]PYRIMIDIN-3-ONES
    Publication number: 20220024939
    Abstract: Compounds of Formula (I) are provided herein. Such compounds, as well as pharmaceutically acceptable salts and compositions thereof, are useful for treating diseases or conditions, including conditions characterized by excessive cellular proliferation, such as breast cancer.
    Type: Application
    Filed: October 8, 2021
    Publication date: January 27, 2022
    Inventors: Peter Qinhua Huang, Kevin Duane Bunker, Brant Clayton Boren, Sayee Gajanan Hegde, Hui Liu, Aditya Krishnan Unni, Sunny Abraham, Chad Daniel Hopkins, Sunil Paliwal
  • 1,2-DIHYDRO-3H-PYRAZOLO[3,4-D]PYRIMIDIN-3-ONE ANALOGS
    Publication number: 20210317124
    Abstract: Compounds of Formula (I) are provided herein. Such compounds, as well as pharmaceutically acceptable salts and compositions thereof, are useful for treating diseases or conditions, including conditions characterized by excessive cellular proliferation, such as breast cancer.
    Type: Application
    Filed: June 15, 2021
    Publication date: October 14, 2021
    Inventors: Peter Qinhua Huang, Brant Clayton Boren, Kevin Duane Bunker, Hui Liu, Sunil Paliwal
  • L,2-dihydro-3H-pyrazolo[3,4-D]pyrimidin-3-one analogs
    Patent number: 11124518
    Abstract: Compounds of Formula (I) are provided herein. Such compounds, as well as pharmaceutically acceptable salts and compositions thereof, are useful for treating diseases or conditions, including conditions characterized by excessive cellular proliferation, such as breast cancer.
    Type: Grant
    Filed: July 31, 2018
    Date of Patent: September 21, 2021
    Assignee: Recurium IP Holdings, LLC
    Inventors: Peter Qinhua Huang, Brant Clayton Boren, Kevin Duane Bunker, Hui Liu, Sunil Paliwal
  • Compounds useful as modulators of TRPM8
    Patent number: 11028052
    Abstract: The present invention includes compounds useful as modulators of TRPM8, such as compounds of Formulae (Ia), (Ib) and (Ic), and the subgenus and species thereof; personal products containing those compounds; and the use of those compounds and the personal products, particularly the use of increasing or inducing chemesthetic sensations, such as cooling or cold sensations.
    Type: Grant
    Filed: September 18, 2019
    Date of Patent: June 8, 2021
    Assignee: Firmenich Incorporated
    Inventors: Lyudmyla Chumakova, Andrew Patron, Chad Priest, Donald Karanewsky, Rachel Kimmich, Brant Clayton Boren, Jeffrey Robert Hammaker, Volodymyr Chumakov, Wen Zhao, Alain Noncovich, Jane Ung
  • SUBSTITUTED 1,2-DIHYDRO-3H-PYRAZOLO[3,4-D]PYRIMIDIN-3-ONES
    Publication number: 20210139482
    Abstract: Compounds of Formula (I) are provided herein. Such compounds, as well as pharmaceutically acceptable salts and compositions thereof, are useful for treating diseases or conditions, including conditions characterized by excessive cellular proliferation, such as breast cancer.
    Type: Application
    Filed: February 26, 2019
    Publication date: May 13, 2021
    Inventors: Peter Qinhua Huang, Kevin Duane Bunker, Brant Clayton Boren, Sayee Gajanan Hegde, Hui Liu, Aditya Krishnan Unni, Sunny Abraham, Chad Daniel Hopkins, Sunil Paliwal
  • ANALGESIC COMPOUNDS
    Publication number: 20200270221
    Abstract: Disclosed herein are compounds of Formulae (Ia), (Ib), (Ic), (Id), (Ie), (If), (Ig), (Ih), (Ik), (Im), (In), (Io), (Ip), (Iq), (Ir), (Is) and (It), methods of synthesizing compounds of Formulae (Ia), (Ib), (Ic), (Id), (Ie), (If), (Ig), (Ih), (Ik), (Im), (In), (Io), (Ip), (Iq), (Ir), (Is) and (It), and methods of using compounds of Formulae (Ia), (Ib), (Ic), (Id), (Ie), (If), (Ig), (Ih), (Ik), (Im), (In), (Io), (Ip), (Iq), (Ir), (Is) and (It) as an analgesic.
    Type: Application
    Filed: May 11, 2018
    Publication date: August 27, 2020
    Inventors: Chad Daniel Hopkins, Joseph Robert Pinchman, Kevin Duane Bunker, Deborah Helen Slee, Brant Clayton Boren, Mehmet Kahraman
  • 1,2-DIHYDRO-3H-PYRAZOLO[3,4-D]PYRIMIDIN-3-ONE ANALOGS
    Publication number: 20200157112
    Abstract: Compounds of Formula (I) are provided herein. Such compounds, as well as pharmaceutically acceptable salts and compositions thereof, are useful for treating diseases or conditions, including conditions characterized by excessive cellular proliferation, such as breast cancer.
    Type: Application
    Filed: July 31, 2018
    Publication date: May 21, 2020
    Inventors: Peter Qinhua Huang, Brant Clayton Boren, Kevin Duane Bunker, Hui Liu, Sunil Paliwal
  • COMPOUNDS USEFUL AS MODULATORS OF TRPM8
    Publication number: 20200010425
    Abstract: The present invention includes compounds useful as modulators of TRPM8, such as compounds of Formulae (Ia), (Ib) and (Ic), and the subgenus and species thereof; personal products containing those compounds; and the use of those compounds and the personal products, particularly the use of increasing or inducing chemesthetic sensations, such as cooling or cold sensations.
    Type: Application
    Filed: September 18, 2019
    Publication date: January 9, 2020
    Inventors: Lyudmyla Chumakova, Andrew Patron, Chad Priest, Donald Karanewsky, Rachel Kimmich, Brant Clayton Boren, Jeffrey Robert Hammaker, Volodymyr Chumakov, Wen Zhao, Alain Noncovich, Jane Ung