Abstract: A patellofemoral implant arrangement for repairing damage in a patellofemoral articulation of a patient is provided. The patellofemoral implant arrangement includes a femoral trochlear implant, including an articulating surface, and a patellar implant, configured to be inserted, for example with press-fit, into a recess in a patella in such a way that the perimeter of an articulating surface of the patellar implant does not extend beyond a surrounding articulating surface of the patella. The articulating surfaces of the femoral trochlear implant and the patellar implant are designed to allow that they at least partly interact with each other when the implants are implanted into the knee joint and the patella lies in the intercondylar groove of the femur. The articulating surface of the patellar implant may be designed to correspond to the curvature of a simulated healthy articulating surface of the undamaged patella at the site of diseased cartilage.

Abstract: The present disclosure concerns a composition for an implantable pharmaceutical composition prepared from components consisting only of calcium sulfate ?-hemihydrate in combination with two antibiotics, vancomycin and gentamicin, for the treatment of infection in bone and soft tissue.

Abstract: Provided herein are methods of differentiating neural cells as well as methods of predicting cell engraftment of populations of cells using gene expression, for instance populations of neuronal progenitor cells, following implantation in a subject. Also provided herein are related compositions, articles of manufacture, and kits, including for use in methods of treating a subject having neurodegenerative disease, for instance Parkinson's disease.

Abstract: Techniques for a machine learning system configured to obtain a dataset of a plurality of sample speech clips; generate a plurality of sequence; initialize a plurality of speaker embeddings and a plurality of accent embeddings; update the plurality of speaker embeddings; update the plurality of accent embeddings; generate a plurality of augmented embeddings based on the plurality of sequence embeddings, the plurality of speaker embeddings, and the plurality of accent embeddings; and generate a plurality of synthetic speech clips based on the plurality of augmented embeddings. The machine learning system may further be configured to obtain an audio waveform; decompose the audio waveform into first magnitude spectral slices and an original phase; process the first magnitude spectral slices to map the first magnitude spectral slices to second magnitude spectral slices; and generate a modified audio waveform in part by combining the second magnitude spectral slices and the original phase.

Abstract: A method, apparatus, and system for creating a script for rendering audio and/or video streams include identifying at least one prosodic speech feature in a received audio stream and/or a received language model, creating a respective prosodic speech symbol for each of the at least one identified prosodic speech features, converting the received audio stream and/or the received language model into a text stream, temporally inserting the created at least one prosodic speech symbol into the text stream, identifying in a received video stream at least one prosodic gesture of at least a portion of a body of a speaker of the received audio stream, creating at least one respective gesture symbol for each of the at least one identified prosodic gestures, and temporally inserting the created at least one gesture symbol into the text stream along with the at least one prosodic speech symbol to create a prosodic script.

Abstract: In accordance with one or more embodiments herein, a system for turning a patient's dysplastic or deformed patellofemoral joint into a healthier patellofemoral joint is provided. The system comprises at least one processor arranged to: analyze the curvature of the patella in a patellofemoral joint; analyze the curvature of the femoral trochlea in said patellofemoral joint; and determine whether any of said analyzed curvatures indicate that the patellofemoral joint is dysplastic or deformed. If any of said analyzed curvatures indicate that the patellofemoral joint is dysplastic or deformed, the at least one processor is arranged to propose an improved curvature of the articulating surface of the patella and/or the femoral trochlea; and determine the shape and dimensions for a patellar implant that would create said improved curvature of the articulating surface of the patella, and/or a trochlear implant that would create said improved curvature of the articulating surface of the femoral trochlea.

Abstract: A compound with the Formula (I): wherein A is of the following formula: and X1 is selected from O, S or NH; X2 is either N or C—H X3 is either N or C—RA3; wherein if X1 is NH and X2 is C—H then X3 is C—RA3; B is of formula (B-1) or (B-2) C is selected from the group consisting of optionally substituted C6-10 carboaryl, C5-6 heteroaryl or C5-10 heterocyclyl, and their use as PCSK9 inhibitors.

Abstract: Systems and methods for down-scaling are provided. In one example, a method for processing image data includes determining a plurality of output pixel locations using a position value stored by a position register, using the current position value to select a center input pixel from the image data and selecting an index value, selecting a set of input pixels adjacent to the center input pixel, selecting a set of filtering coefficients from a filter coefficient lookup table using the index value, filtering the set of source input pixels to apply a respective one of the set of filtering coefficients to each of the set of source input pixels to determine an output value for the current output pixel at the current position value, and correcting chromatic aberrations in the set of source input pixels.

Abstract: A processor arranged to compress neural network activation data comprising an input module for obtaining neural network activation data. The processor also comprises a block creation module arranged to split the neural network activation data into a plurality of blocks; and a metadata generation module for generating metadata associated with at least one of the plurality of blocks. Based on the metadata generated a selection module selects a compression scheme for each of the plurality of blocks, and a compression module for applying the selected compression scheme to the corresponding block to produce compressed neural network activation data. An output module is also provided for outputting the compressed neural network activation data.

Abstract: Disclosed herein are system, apparatus, article of manufacture, method, and computer program product embodiments for adapting an automated speech recognition system to provide more accurate suggestions to voice queries involving media content including recently created or recently available content. An example computer-implemented method includes transcribing the voice query, identifying respective components of the query such as the media content being requested and the action to be performed, and generating fuzzy candidates that potentially match the media content based on phonetic representations of the identified components. Phonetic representations of domain specific candidates are stored in a domain entities index and is continuously updated with new entries so as to maintain the accuracy of the speech recognition of voice queries for recently created or recently available content.

Abstract: A grounding device for a vehicle can comprise a conducting means and two contact elements, wherein the conducting means comprises at least one flat braided wire assembly configured to conduct high frequency currents, wherein a first contact element of the two contact elements is arranged at a first axial end of the conducting means and a second contact element of the two contact elements is arranged at a second axial end of the conducting means, wherein the first contact element is further configured to be attached to a first component of the vehicle, and the second contact element is further configured to be attached to a second component of the vehicle, and wherein the conducting means is formed at least partly as a spring element, configured to provide an elastic expansion or an elastic compression in at least two dimensions.

Abstract: A speculum operable to be disposed within an ear of a subject may include a housing. The housing may include a light conducting element. A transmitted optical illumination may be conducted by total internal reflection via the light conducting element. The housing may include a lumen. The housing may be configured to allow a reflected optical illumination to propagate through the lumen. The speculum may include one or more coupling portions which couple the transmitted optical illumination from a light source to the light conducting element. The one or more coupling portions may be shaped as a conic section.

Abstract: Disclosed herein are system, apparatus, article of manufacture, method, and computer program product embodiments for adapting an automated speech recognition system to provide more accurate suggestions to voice queries involving media content including recently created or recently available content. An example computer-implemented method includes transcribing the voice query, identifying respective components of the query such as the media content being requested and the action to be performed, and generating fuzzy candidates that potentially match the media content based on phonetic representations of the identified components. Phonetic representations of domain specific candidates are stored in a domain entities index and is continuously updated with new entries so as to maintain the accuracy of the speech recognition of voice queries for recently created or recently available content.

Abstract: Systems and methods are disclosed herein that can detect at least one activity by parsing text from an operation of a consumer electronics device and determine that the at least one activity matches a risk scenario.

Abstract: Systems and methods for down-scaling are provided. In one example, a method for processing image data includes determining a plurality of output pixel locations using a position value stored by a position register, using the current position value to select a center input pixel from the image data and selecting an index value, selecting a set of input pixels adjacent to the center input pixel, selecting a set of filtering coefficients from a filter coefficient lookup table using the index value, filtering the set of source input pixels to apply a respective one of the set of filtering coefficients to each of the set of source input pixels to determine an output value for the current output pixel at the current position value, and correcting chromatic aberrations in the set of source input pixels.

Abstract: Systems and methods are disclosed herein that can detect use of a consumer electronics device and that can generate and offer insurance or protection plans that measure, account, and adjust for the use of the consumer electronics device and consumer tendencies while using the consumer electronics device.

Abstract: Systems and methods are disclosed herein that can detect use of a consumer electronics device and that can generate and offer insurance or protection plans that measure, account, and adjust for the use of the consumer electronics device and consumer tendencies while using the consumer electronics device.

Abstract: There is provided a dual-slope analog-to-digital converter (ADC), comprising an input signal terminal, configured to provide an analog signal, and a reference signal terminal, configured to provide a predetermined reference signal. The ADC further comprises an integrator, that is operatively coupled to said input signal terminal and said reference signal terminal via a first switch unit, said first switch unit being configured to selectively connect and disconnect said integrator to and from any one of said input signal terminal and said reference signal terminal.

Abstract: An automated interactive voice dialogue system using a human-in-the-loop design may enable human-supported interventions, where the automated system still conducts most of the interaction but enables a human agent to assume control of the dialogue and assist, if deemed necessary, so that the user may continue the interaction with little interruption or frustration. In some examples, the user of the dialogue system of this disclosure may not realize that there was a problem, and that the interaction is being or has switched from an automated dialogue system to a human. In some examples, the automated dialogue system of this disclosure may also automatically switch back to machine interaction when the human agent has resolved the situation.

Abstract: The present disclosure provides methods of correcting gene variants associated with Parkinson's Disease in pluripotent stem cells, and methods of lineage specific differentiation of such corrected pluripotent stem cells into floor plate midbrain progenitor cells, determined dopamine (DA) neuron progenitor cells, and/or DA neurons, or into glial cells, such as microglial cells, astrocytes, oligodendrocytes, or ependymocytes. Also provided are compositions uses thereof, such as for treating neurodegenerative diseases and conditions, including Parkinson's disease.