Patents by Inventor Braydon C. Guild

Braydon C. Guild has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Novel apoptosis gene EI24, compositions, and methods of use
    Publication number: 20090081642
    Abstract: Disclosed is the isolation and characterization of EI24, a novel gene whose 2.4 kb mRNA is induced following etoposide treatment. Induction of EI24 mRNA by etoposide required expression of wild-type p53. Overexpression of functional p53 was sufficient to induce expression of the EI24 mRNA. The EI24 mRNA was also induced in a p53-dependent manner by ionizing irradiation of primary murine thymocytes. The invention is thus directed to an isolated EI24 protein, nucleotide sequences coding for and regulating expression of the protein, antibodies directed against the protein, and recombinant vectors and host cells containing the genetic sequences coding for and regulating the expression of the protein sequence. The invention is also directed to genomic DNA, cDNA, and RNA encoding the EI24 protein sequence and to corresponding antisense RNA sequences. Antibodies can be used to detect EI24 in biological specimens, including, for example, human tissue samples.
    Type: Application
    Filed: April 21, 2006
    Publication date: March 26, 2009
    Applicant: Apoptosis Technology, Inc.
    Inventors: Sophie M. Lehar, Braydon C. Guild
  • Antibodies for apoptosis EI24 protein and methods of use
    Patent number: 7078175
    Abstract: Disclosed is the isolation and characterization of EI24, a gene whose 2.4 kb mRNA is induced following etoposide treatment. Induction of EI24 mRNA by etoposide required expression of wild-type p53. Overexpression of functional p53 was sufficient to induce expression of the EI24 mRNA. The EI24 mRNA was also induced in a p53-dependent manner by ionizing irradiation of primary murine thymocytes. The invention is thus directed to an isolated EI24 protein, nucleotide sequences coding for and regulating expression of the protein, antibodies directed against the protein, and recombinant vectors and host cells containing the genetic sequences coding for and regulating the expression of the protein sequence. Antibodies can be used to detect EI24 in biological specimens, including, for example, human tissue samples.
    Type: Grant
    Filed: March 12, 2003
    Date of Patent: July 18, 2006
    Assignee: Immunogen, Inc.
    Inventors: Sophie M. Lehar, Braydon C. Guild
  • Nucleic acid and amino acid sequences relating to Helicobacter pylori for diagnostics and therapeutics
    Publication number: 20040052799
    Abstract: Recombinant or substantially pure preparations of H. pylori polypeptides are described. The nucleic acids encoding the polypeptides also are described. The H. pylori polypeptides are useful for diagnostics and vaccine compositions.
    Type: Application
    Filed: December 30, 2002
    Publication date: March 18, 2004
    Applicant: Astra Aktiebolag
    Inventors: Douglas Smith, Richard A. Alm, O. Thomas Berglindh, Bjorn L. Mellgard, Steven R. Thomas, Eric Brown, Donald T. Moir, Lo See Ling, Gilles Carmel, Braydon C. Guild, Peter C. Doig, Zita Kabok, Lillian Marie Castriotta
  • Compositions, kits, and methods for identification, assessment, prevention, and therapy of rheumatoid arthritis
    Publication number: 20030224386
    Abstract: The invention relates to compositions, kits, and methods for detecting, characterizing, preventing, and treating human Rheumatoid Arthritis (RA). A variety of newly-identified markers are provided, wherein changes in the levels of expression of one or more of the markers is correlated with RA.
    Type: Application
    Filed: December 16, 2002
    Publication date: December 4, 2003
    Applicant: Millennium Pharmaceuticals, Inc.
    Inventors: Braydon C. Guild, Hua Liao, Michael D. Jones, Johannes W. Zolg, Jiang Wu
  • Antibodies for apoptosis EI24 protein and methods of use
    Publication number: 20030157683
    Abstract: Disclosed is the isolation and characterization of EI24, a novel gene whose 2.4 kb mRNA is induced following etoposide treatment. Induction of EI24 mRNA by etoposide required expression of wild-type p53. Overexpression of functional p53 was sufficient to induce expression of the EI24 mRNA. The EI24 mRNA was also induced in a p53-dependent manner by ionizing irradiation of primary murine thymocytes. The invention is thus directed to an isolated EI24 protein, nucleotide sequences coding for and regulating expression of the protein, antibodies directed against the protein, and recombinant vectors and host cells containing the genetic sequences coding for and regulating the expression of the protein sequence. The invention is also directed to genomic DNA, cDNA, and RNA encoding the EI24 protein sequence and to corresponding antisense RNA sequences. Antibodies can be used to detect EI24 in biological specimens, including, for example, human tissue samples.
    Type: Application
    Filed: March 12, 2003
    Publication date: August 21, 2003
    Inventors: Sophie M. Lehar, Braydon C. Guild
  • Apoptosis gene EI24, compositions, and methods of use
    Patent number: 6586204
    Abstract: Disclosed is the isolation and characterization of EI24, a novel gene whose 2.4 kb mRNA is induced following etoposide treatment. Induction of EI24 mRNA by etoposide required expression of wild-type p53. Overexpression of functional p53 was sufficient to induce expression of the EI24 mRNA. The EI24 mRNA was also induced in a p53-dependent manner by ionizing irradiation of primary murine thymocytes. The invention is thus directed to an isolated EI24 protein, nucleotide sequences coding for and regulating expression of the protein, antibodies directed against the protein, and recombinant vectors and host cells containing the genetic sequences coding for and regulating the expression of the protein sequence. The invention is also directed to genomic DNA, cDNA, and RNA encoding the EI24 protein sequence and to corresponding antisense RNA sequences. Antibodies can be used to detect EI24 in biological specimens, including, for example, human tissue samples.
    Type: Grant
    Filed: September 11, 1998
    Date of Patent: July 1, 2003
    Assignee: Apoptosis Technology, Inc.
    Inventors: Sophie M. Lehar, Braydon C. Guild
  • NOVEL APOPTOSIS GENE 3I24, COMPOSITIONS, AND METHODS OF USE
    Publication number: 20020192745
    Abstract: Disclosed is the isolation and characterization of E124, a novel gene whose 2.4 kb mRNA is induced following etoposide treatment. Induction of EI24 mRNA by etoposide required expression of wild-type p53. Overexpression of functional p53 was sufficient to induce expression of the EI24 mRNA. The EI24 mRNA was also induced in a p53-dependent manner by ionizing irradiation of primary murine thymocytes. The invention is thus directed to an isolated EI24 protein, nucleotide sequences coding for and regulating expression of the protein, antibodies directed against the protein, and recombinant vectors and host cells containing the genetic sequences coding for and regulating the expression of the protein sequence. The invention is also directed to genomic DNA, cDNA, and RNA encoding the EI24 protein sequence and to corresponding antisense RNA sequences. Antibodies can be used to detect EI24 in biological specimens, including, for example, human tissue samples.
    Type: Application
    Filed: September 11, 1998
    Publication date: December 19, 2002
    Inventors: SOPHIE M. LEHAR, BRAYDON C. GUILD
  • Apoptosis gene EI24, compositions, and methods of use
    Patent number: 5843659
    Abstract: Disclosed is the isolation and characterization of EI24, a novel gene whose 2.4 kb mRNA is induced following etoposide treatment. Induction of EI24 mRNA by etoposide required expression of wild-type p53. Overexpression of functional p53 was sufficient to induce expression of the EI24 mRNA. The EI24 mRNA was also induced in a p53-dependent manner by ionizing irradiation of primary murine thymocytes. The invention is thus directed to an isolated EI24 protein, nucleotide sequences coding for and regulating expression of the protein, antibodies directed against the protein, and recombinant vectors and host cells containing the genetic sequences coding for and regulating the expression of the protein sequence. The invention is also directed to genomic DNA, cDNA, and RNA encoding the EI24 protein sequence and to corresponding antisense RNA sequences. Antibodies can be used to detect EI24 in biological specimens, including, for example, human tissue samples.
    Type: Grant
    Filed: March 21, 1996
    Date of Patent: December 1, 1998
    Assignee: Apoptosis Technology, Inc.
    Inventors: Sophie M. Lehar, Braydon C. Guild
  • Resurfacing of rodent antibodies
    Patent number: 5639641
    Abstract: The invention relates to a method for providing, via resurfacing, humanized rodent antibodies that have improved therapeutic efficacy due to the presentation of a human surface in the variable region.
    Type: Grant
    Filed: September 9, 1992
    Date of Patent: June 17, 1997
    Assignee: Immunogen Inc.
    Inventors: Jan T. Pedersen, Stephen M. J. Searle, Anthony R. Rees, Michael A. Roguska, Braydon C. Guild