Abstract: Disclosed herein telomerase inhibitors and controlled-release formulations thereof, the use of telomerase-inhibiting porphyrins, especially metalloporphyrins, in the controlled-release intratumoral implants for the treatment of cancer. Provided herein also specific compositions of metalloporphyrins and poly-(lactic-co-glycolic)-acid copolymers, in various implantable forms, and methods of treatment cancer by administering the implants of the invention, alongside possible co-treatment with brachytherapy radioactive seeds to precipitate Auger effect of the metal atoms contained in the metalloporphyrins.

Abstract: Disclosed herein telomerase inhibitors and controlled-release formulations thereof, the use of telomerase-inhibiting porphyrins, especially metalloporphyrins, in the controlled-release intratumoral implants for the treatment of cancer. Provided herein also specific compositions of metalloporphyrins and poly-(lactic-co-glycolic)-acid copolymers, in various implantable forms, and methods of treatment cancer by administering the implants of the invention, alongside possible co-treatment with brachytherapy radioactive seeds to precipitate Auger effect of the metal atoms contained in the metalloporphyrins.

Abstract: A method for the treatment of a tumor, comprising administering to a subject a therapeutically effective amount of a complex of a heavy element with a polydentate, pyrrole-containing macrocyclic ligand substituted with charged chemical groups, wherein said complex is capable of bringing said heavy element into close proximity to the nuclear DNA of cells in said tumors, and irradiating said tumor with photons above the K or L shell adsorption edge of said heavy element to elicit the emission of densely ionizing Auger electrons at the level of DNA.

Abstract: A method for densely packaging an element inside a casing, such that the element-containing casing is suitable for use in the preparation of a radiation source, comprising providing a solution containing ions of said element, positioning a working electrode and at least one counter electrode in contact with said solution, connecting said working electrode and said at least one counter electrode to the negative and positive poles of a power source, respectively, passing an electrical current between said electrodes to electrochemically deposit said element on said working electrode in a geometrical form corresponding to the form of the interior of the casing and concurrently or sequentially loading said casing with said element.

Abstract: A method for the treatment of a tumor, comprising administering to a subject a therapeutically effective amount of a complex of a heavy element with a polydentate, pyrrole-containing macrocyclic ligand substituted with charged chemical groups, wherein said complex is capable of bringing said heavy element into close proximity to the nuclear DNA of cells in said tumors, and irradiating said tumor with photons above the K or L shell adsorption edge of said heavy element to elicit the emission of densely ionizing Auger electrons at the level of DNA.