Patents by Inventor Brenda S. Price

Brenda S. Price has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Modified Streptomyces host cells for increased avermectin production and methods of making the same
    Patent number: 6689611
    Abstract: The present invention is directed to compositions and methods for producing avermectins, and is primarily in the field of animal health. The present invention relates to the identification and characterization of two novel genes, herein referred to as the aveR1 and aveR2 genes, that are involved in regulating avermectin polyketide synthase (PKS) expression and avermectin biosynthesis in Streptomyces avermitilis. The present invention is based on the discovery that inactivation of these genes results in an increase in the amount of avermectin produced by S. avermitilis.
    Type: Grant
    Filed: November 16, 2000
    Date of Patent: February 10, 2004
    Assignee: Pfizer Inc.
    Inventors: Kim J. Stutzman-Engwall, Brenda S. Price
  • Streptomyces avermitilis regulatory genes for increased avermectin production
    Patent number: 6197591
    Abstract: The present invention is directed to compositions and methods for producing avermectins, and is primarily in the field of animal health. The present invention relates to the identification and characterization of two novel genes, herein referred to as the aveR1 and aveR2 genes, that are involved in regulating avermectin polyketide synthase (PKS) expression and avermectin biosynthesis in Streptomyces avermitilis. The present invention is based on the discovery that inactivation of these genes results in an increase in the amount of avermectin produced by S. avermitilis.
    Type: Grant
    Filed: September 7, 1999
    Date of Patent: March 6, 2001
    Assignee: Pfizer Inc.
    Inventors: Kim J. Stutzman-Engwall, Brenda S. Price