Patents by Inventor Brenda Winkel

Brenda Winkel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Supramolecular metallic complexes exhibiting both DNA binding and photocleavage
    Patent number: 8148360
    Abstract: Supramolecular complexes that target and cleave DNA are provided. The supramolecular complexes include at least one metal-to-ligand charge transfer (MLCT) light absorbing unit, at least one Pt based DNA binding unit, and at least one bridging unit that serves to connect the components. The Pt-based DNA binding unit binds the complex to DNA, and the MLCT unit absorbs light, thereby sensitizing molecular oxygen to produce reactive oxygen species in close proximity to the complex and the bound DNA. The reactive oxygen species cleave the bound DNA.
    Type: Grant
    Filed: September 7, 2007
    Date of Patent: April 3, 2012
    Assignee: Virginia Tech Intellectual Properties, Inc.
    Inventors: Karen J. Brewer, Brenda Winkel
  • Supramolecular Metallic Complexes Exhibiting Both DNA Binding and Photocleavage
    Publication number: 20080113954
    Abstract: Supramolecular complexes that target and cleave DNA are provided. The supramolecular complexes include at least one metal-to-ligand charge transfer (MLCT) light absorbing unit, at least one Pt based DNA binding unit, and at least one bridging unit that serves to connect the components. The Pt-based DNA binding unit binds the complex to DNA, and the MLCT unit absorbs light, thereby sensitizing molecular oxygen to produce reactive oxygen species in close proximity to the complex and the bound DNA. The reactive oxygen species cleave the bound DNA.
    Type: Application
    Filed: September 7, 2007
    Publication date: May 15, 2008
    Inventors: Karen J. Brewer, Brenda Winkel