Abstract: A system to perform electroporation ablation of target tissue in a chamber of a patient's heart, the system comprising a catheter and a controller. The catheter includes an electrode assembly having a plurality of ablation electrodes, wherein the catheter is adapted to position the electrode assembly in contact with the target tissue. The controller is configured to identify, from among the plurality of ablation electrodes, a first subset of ablation electrodes that are in contact with the target tissue, and a second subset of ablation electrodes that are not in contact with the target tissue, and to apply a pulsed electrical signal to the first subset of ablation electrodes and not to the second subset of ablation electrodes.

Abstract: At least some embodiments of the present disclosure are directed to an electroporation ablation system for treating targeted tissue in a patient. The electroporation ablation system comprises an ablation catheter including catheter electrodes configured to generate electric fields in the targeted tissue in response to a plurality of electrical pulse sequences delivered in a plurality of therapy sections; a controller configured to receive a first pulse voltage of a first electrical pulse sequence measured during a first therapy section of the plurality of therapy sections; and determine a charge voltage based on the first pulse voltage; and an electroporation generator. The electroporation generator is operatively coupled to the catheter electrodes and the controller and configured to deliver a second electrical pulse sequence at a controlled pulse voltage for a second therapy section of the plurality of therapy sections.

Abstract: A leadless pacing device may include a housing having a proximal end and a distal end, and one or more electrodes supported by the housing. The housing may include a body portion and a header. A distal extension may extend distally from the header of the housing, the distal extension including one or more electrodes. The header may include a guide wire port and a guide wire lumen may extend from the guide wire port through the header of the housing and through the distal extension. A fixation member may extend from the header of the housing. The header may be formed from an over mold process.

Abstract: A catheter for ablation of tissue through irreversible electroporation is disclosed. The catheter includes a tubular outer shaft having a distal end, a mapping electrode assembly extending distally from the distal end of the outer shaft, and an ablation electrode assembly. the electrode assembly defines a distally located central hub portion and a plurality of splines each including a distal end portion extending from the central hub portion, and a proximal end portion attached to and constrained by the outer shaft, the splines defining an inner space in an expanded configuration, each of the plurality of splines including a plurality of outwardly-facing sensing electrodes; and an ablation electrode assembly extending distally from the distal end of the outer shaft, the ablation electrode assembly disposed in the inner space.

Abstract: An electroporation catheter for ablation of cardiac tissue is disclosed. The electroporation catheter includes an elongated shaft having a proximal end and an opposite distal end. The elongated shaft defines an axis. An electrode assembly is coupled to and extends distally from the distal end of the elongated shaft. The electrode assembly is transitionable between a collapsed state and an expanded state. The electrode assembly includes conductive struts that define a spherical shape in the expanded state having a proximal portion coupled to the elongated shaft, a central portion having a maximum radial dimension and a distal portion opposite the elongated shaft. A proximal insulation portion is disposed on the proximal portion of the electrode assembly surrounding each of the plurality of conductive struts. The proximal insulator portion extends from the proximal end to at least the central portion.

Abstract: An implantable medical device (IMD) is configured with a pressure sensor. The IMD includes a housing and a diaphragm that is exposed to the environment outside of the housing. The diaphragm is configured to transmit a pressure from the environment outside of the housing to a piezoelectric membrane. In response, the piezoelectric membrane generates a voltage and/or a current, which is representative of a pressure change applied to the housing diaphragm. In some cases, only changes in pressure over time are used, not absolute or gauge pressures.

Abstract: A method to treat sacroiliac joint pain includes inserting at least one ablation electrode into a patient to ablate at least one spinal nerve extending from the spinal cord in the vertebral range of the lumbar vertebrae L3, L4, or L5 or any of the sacral vertebrae; and applying pulses to the at least one ablation electrode to ablate the at least one nerve, wherein each of the pulses has a duration of no more than 500 microseconds and at least some of the pulses have a voltage of at least 1 kV or generate an electric field of at least 3 kV/cm.

Abstract: A method for basivertebral nerve ablation includes inserting at least one ablation electrode into a vertebral body of a patient; and applying pulses to the ablation electrode to ablate the basivertebral nerve within the vertebral body, wherein each of the pulses has a duration of no more than 500 microseconds and at least some of the pulses have a voltage of at least 1 kV or generate an electric field of at least 3 kV/cm.

Abstract: Medical devices and methods for making and using medical devices are disclosed. An example medical device may include an implantable medical device. The implantable medical device may include an implantable pacing member having a housing and a lead input. A lead may be coupled to the lead input. The lead may be designed to extend along a pericardial space, epicardium, or both and engage a heart chamber. A passageway may be defined along a portion of the length of the lead.

Abstract: An implantable medical device (IMD) is configured with a pressure sensor. The IMD includes a housing and a diaphragm that is exposed to the environment outside of the housing. The diaphragm is configured to transmit a pressure from the environment outside of the housing to a piezoelectric membrane. In response, the piezoelectric membrane generates a voltage and/or a current, which is representative of a pressure change applied to the housing diaphragm. In some cases, only changes in pressure over time are used, not absolute or gauge pressures.

Abstract: Medical devices and methods for making and using medical devices are disclosed. An example medical device may include an implantable medical device. The implantable medical device may include an implantable pacing member having a housing and a lead input. A lead may be coupled to the lead input. The lead may be designed to extend along a pericardial space, epicardium, or both and engage a heart chamber. A passageway may be defined along a portion of the length of the lead.

Abstract: A system for facilitating an ablation in a patient's heart is disclosed. The system includes a catheter and a controller. The catheter includes an electrode assembly having spaced-apart electrodes disposed on splines to generate an electric field in the heart, the splines configurable in an expanded position wherein the plurality of spaced-apart electrodes are in a selected spatial relationship, and wherein the splines are deformable relative to the expanded configuration when subjected to a force. The controller is configured to measure an electrical signal received from an electrode of the spaced-apart electrodes in response to the electric field, the electrical signal indicative of a parameter of the electric field, and the controller configured to determine a deformation of the splines relative to the expanded position based on the measured electrical signal.

Abstract: A system for performing electroporation ablation of target tissue in a chamber of a patient's heart is disclosed. The system including a catheter including an electrode assembly having a plurality of electrodes, wherein the catheter is adapted to position the electrode assembly at a plurality of locations proximate the target tissue, a graphical display, and a controller. The controller configured to generate, on the graphical display, a graphical representation of the electrode assembly. The controller configured to generate, on the graphical display, a graphical representation of a model of electric fields generated in response to delivery of pulsed electrical signals to selected ones of the plurality of electrodes.

Abstract: A leadless pacing device may include a housing having a proximal end and a distal end, and one or more electrodes supported by the housing. The housing may include a body portion and a header. A distal extension may extend distally from the header of the housing, the distal extension including one or more electrodes. The header may include a guide wire port and a guide wire lumen may extend from the guide wire port through the header of the housing and through the distal extension. A fixation member may extend from the header of the housing. The header may be formed from an over mold process.

Abstract: A ventricularly implantable medical device that includes a sensing module that is configured to detect an atrial fiducial and identify an atrial contraction based at least on part on the detected atrial fiducial. Control circuitry in the implantable medical device is configured to deliver a ventricular pacing therapy to a patient's heart based at least in part on the identified atrial contraction, and can automatically switch or revert the ventricular pacing therapies on the fly.

Abstract: At least some embodiments of the present disclosure are directed to systems and methods for estimating locations of electrodes and/or electrode assembly of an electroporation ablation catheter using one or more navigation sensors integrated with the catheter. In some examples, the electrode assembly includes a plurality of splines and a navigation sensor is disposed on or integrated with one of the plurality of splines. In some examples, a navigation sensor is disposed on o integrated with a supporting structure of the catheter.

Abstract: Implantable medical devices (IMD), such as but not limited to leadless cardiac pacemakers (LCP), subcutaneous implantable cardioverter defibrillators (SICD), transvenous implantable cardioverter defibrillators, neuro-stimulators (NS), implantable monitors (IM), may be configured to communicate with each other. In some cases, a first IMD may transmit instructions to a second IMD. In order to improve the chances of a successfully received transmission, the first IMD may transmit the instructions several times during a particular time frame, such as during a single heartbeat. If the second IMD receives the message more than once, the second IMD recognizes that the messages were redundant and acts accordingly.

Abstract: Delivery devices, systems, and methods for delivering implantable leadless pacing devices are disclosed. An example delivery device may include an outer tubular member including a lumen extending from a proximal end to a distal end thereof and an intermediate tubular member including a lumen extending from a proximal end to a distal end thereof. A distal holding section may be coupled to the intermediate tubular member and define a cavity therein for receiving a proximal implantable leadless pacing device and a distal implantable leadless pacing device in a linear arrangement. The distal holding section may have a proximal body portion and a distal body portion. The proximal body portion may be more flexible than the distal body portion. An inner tubular member including a lumen extending from a proximal end to a distal end thereof may be slidably disposed within the lumen of the intermediate tubular member.

Abstract: A system may include a leadless cardiac pacing device including a body, a proximal hub, and a helical fixation member opposite the proximal hub; and a first elongate shaft having a lumen extending from a distal end of the elongate shaft proximally into the elongate shaft and a transverse member extending transversely across the lumen. The proximal hub may include a transverse channel extending into the proximal hub, the transverse channel being configured to engage the transverse member.

Abstract: Various aspects of the present disclosure are directed toward apparatuses, systems, and methods for electroporation ablation. The electroporation catheter may include an electrode assembly comprising one or more ablation electrodes configured to generate electric fields proximate to target tissue in response to a plurality of electrical pulse sequences delivered in a plurality of therapy sections, and one or more mapping electrodes configured to measure cardiac electrical signals. In some embodiments, the measured electrical signals are used to create an electro-anatomical map.