Patents by Inventor Brendan F. Dutter

Brendan F. Dutter has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Rhodol-based thallium sensors for high-throughput screening of potassium channels
    Patent number: 11519859
    Abstract: Provided are novel rhodol-based compounds, the preparation method thereof, and use thereof in Tl+ flux assays. The fluorescent thallium ion sensor compounds have a rhodol fluorophore attached to an amino dicarboxylic acid metal binding moiety. The compounds are prepared in the “pro-dye” form, with the rhodol oxygen and the carboxylic acids of the metal binding unit masked by protecting groups. The disclosed compounds may be used as more red-shifted and less pH-sensitive variants of Thallos.
    Type: Grant
    Filed: April 9, 2019
    Date of Patent: December 6, 2022
    Assignee: Vanderbilt University
    Inventors: Charles David Weaver, Brendan F. Dutter, Gary A. Sulikowski
  • RHODOL-BASED THALLIUM SENSORS FOR HIGH-THROUGHPUT SCREENING OF POTASSIUM CHANNELS
    Publication number: 20190308991
    Abstract: Provided are novel rhodol-based compounds, the preparation method thereof, and use thereof in Tl+ flux assays. The disclosed compounds may be used as more red-shifted and less pH-sensitive variants of Thallos.
    Type: Application
    Filed: April 9, 2019
    Publication date: October 10, 2019
    Inventors: Charles David Weaver, Brendan F. Dutter, Gary A. Sulikowski