Patents by Inventor Brendan John MANNING

Brendan John MANNING has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CRISPR-BASED SARS-COV-2 DETECTION
    Publication number: 20240052436
    Abstract: The present disclosure provides methods and compositions for the detection of SARS-CoV-2 by CRISPR/Cas collateral RNAse activity.
    Type: Application
    Filed: June 11, 2021
    Publication date: February 15, 2024
    Inventors: Xiang Li, Mary Katherine Wilson, Christine Marie Coticchia, Brendan John Manning, William Jeremy Blake, Elizabeth Mae Selleck Fiore
  • DETECTION ASSAYS
    Publication number: 20230272458
    Abstract: The present disclosure provides improved detection (e.g., diagnostic) assays that utilize a Cas protein collateral cleavage activity.
    Type: Application
    Filed: November 18, 2022
    Publication date: August 31, 2023
    Inventors: William Jeremy Blake, Xiang Li, Mary Katherine Wilson, Christine Marie Coticchia, Brendan John Manning, Pradeep Ramesh
  • IMPROVED DETECTION ASSAYS
    Publication number: 20230183783
    Abstract: The present disclosure provides improved detection (e.g., diagnostic) assays that utilize a Cas protein collateral cleavage activity.
    Type: Application
    Filed: January 27, 2021
    Publication date: June 15, 2023
    Inventors: William Jeremy Blake, Xiang Li, Mary Katherine Wilson, Christine Marie Coticchia, Brendan John Manning, Pradeep Ramesh
  • METHODS AND COMPOSITIONS FOR HIGH SENSITIVITY DETECTION OF DRUG RESISTANCE MARKERS
    Publication number: 20220380834
    Abstract: Provided herein are methods of amplifying and detecting drug resistance markers (e.g., antibiotic resistance genes) from pathogens in complex samples (e.g., blood), as well as related panels and compositions (e.g., systems, cartridges, and kits).
    Type: Application
    Filed: October 4, 2019
    Publication date: December 1, 2022
    Inventors: Jessica Lee SNYDER, Brendan John MANNING, Daniel GAMERO, Heidi Susanne GIESE, Thomas J. LOWERY, Jr.
  • METHODS AND COMPOSITIONS FOR HIGH SENSITIVITY DETECTION OF BIOTHREAT PATHOGENS
    Publication number: 20220372555
    Abstract: Provided herein are methods of amplifying and detecting biothreat pathogens in complex samples (e.g., blood), as well as related panels and compositions (e.g., systems, cartridges, and kits).
    Type: Application
    Filed: June 10, 2020
    Publication date: November 24, 2022
    Inventors: Jessica Lee SNYDER, Daniel GAMERO, Robert Patrick SHIVERS, Kristen ROBERTS, Joseph MARTURANO, Thomas J. LOWERY, Jr., Roger SMITH, Brendan John MANNING
  • METHODS AND COMPOSITIONS FOR COMPREHENSIVE AND HIGH SENSITIVITY DETECTION OF PATHOGENS AND DRUG RESISTANCE MARKERS
    Publication number: 20220348986
    Abstract: Provided herein are methods of amplifying and detecting pathogens and drug resistance markers (e.g., antibiotic resistance genes) in complex samples (e.g., blood), as well as related panels and compositions (e.g., primers, probes, magnetic particles, systems, cartridges, and kits). The methods, panels, and compositions can be used for comprehensive detection of pathogens and drug resistance markers for patient identification, patient selection, optimization of therapies, and antimicrobial stewardship.
    Type: Application
    Filed: June 19, 2020
    Publication date: November 3, 2022
    Inventors: Jessica Lee SNYDER, Joseph MARTURANO, Sandy ESTRADA, Robert Patrick SHIVERS, Roger SMITH, Brendan John MANNING, Thomas J. LOWERY, Jr., Daniel GAMERO, Mohamed Nabuan NAUFER, Kelly N. BURGESS
  • METHODS AND COMPOSITIONS FOR HIGH SENSITIVITY SEQUENCING IN COMPLEX SAMPLES
    Publication number: 20220282310
    Abstract: Provided herein are methods of detecting and sequencing target nucleic acids in complex samples (e.g., blood), as well as related panels and compositions (e.g., systems, cartridges, and kits).
    Type: Application
    Filed: September 10, 2019
    Publication date: September 8, 2022
    Applicants: T2 Biosystems, Inc., T2 Biosystems, Inc.
    Inventors: Jessica Lee SNYDER, Brendan John MANNING, Christopher STEELE, Roger SMITH, Heidi Susanne GIESE, Yin Shan Cathy WONG, Daniel GAMERO, Thomas J. LOWERY, Jr.
  • NMR METHODS AND SYSTEMS FOR THE RAPID DETECTION OF CANDIDA SPECIES
    Publication number: 20200291488
    Abstract: The invention features methods, systems, and panels for rapid detection of Candida species (e.g., Candida auris, Candida lusitaniae, Candida haemulonii, Candida duobushaemulonii, and Candida pseudohaemulonii) in biological samples (e.g., whole blood) and environmental samples (e.g., environmental swabs, e.g., surface swabs), and for diagnosis and monitoring of diseases, including Candidiasis and sepsis.
    Type: Application
    Filed: May 17, 2018
    Publication date: September 17, 2020
    Inventors: Brendan John MANNING, Jessica Lee SNYDER, Benjamin Nguyen CHANG, Trissha Ritsue HIGA, Robert Patrick SHIVERS, Yin Shan Cathy WONG, Thomas Jay LOWERY, Jr., Urvi VED, Daniel GAMERO