Abstract: Disclosed herein are heterocyclic compounds that inhibit the binding of menin and MLL or MLL fusion proteins. Also described are specific inhibitors of menin-MLL interaction. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the menin-MLL inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, leukemia and other diseases or conditions dependent on menin-MLL interaction; or a pharmaceutically acceptable salt thereof.

Abstract: Disclosed herein are heterocyclic compounds that inhibit the binding of menin and MLL or MLL fusion proteins. Also described are specific irreversible inhibitors of menin-MLL interaction. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the menin-MLL irreversible inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, leukemia and other diseases or conditions dependent on menin-MLL inter-action; or a pharmaceutically acceptable salt thereof.

Abstract: Systems and methods for reconstructing an image of a subject or object based on a plurality of measured signals representing the subject or object obtained by an imaging device are disclosed. The systems and methods reconstruct the image of the subject or object by performing an iterative reconstruction method to produce a plurality of intermediate images and the image of the subject, and transforming at least one selected intermediate image from the plurality of intermediate images using a quasi-projection operator. The quasi-projection operator includes a deep-learning model configured to map the at least one selected intermediate image to at least one regularized intermediate image. In addition, systems and methods for training the deep-learning model using a training data set that includes a plurality of training images and a plurality of corresponding training object images is disclosed.

Abstract: A method watermarks speech data by using a generator to generate speech data including a watermark. The generator is trained to generate the speech data including the watermark. The training process generates first speech from the generator. The first speech data is configured to represent speech. The first speech data includes a candidate watermark. The training also produces an inconsistency message as a function of at least one difference between the first speech data and at least authentic speech data. The training further includes transforming the first speech data, including the candidate watermark, using a watermark robustness module to produce transformed speech data including a transformed candidate watermark. The transformed speech data includes a transformed candidate watermark. The training further produces a watermark-detectability message, using a watermark detection machine learning system, relating to one or more desirable watermark features of the transformed candidate watermark.

Abstract: The present disclosure provides a production method for artificial pluripotent stem cells, the method comprising preparing somatic cells, and introducing a Sendai virus including reprogramming factor RNA into the somatic cell. The present disclosure also provides a production method for artificial pluripotent stem cells, the method comprising preparing somatic cells, introducing reprogramming factor RNA into the somatic cells using an RNA transfection reagent, and reprogramming the somatic cells in a gel culture medium.

Abstract: Disclosed is a system and method for extraction of information of within sample distribution of fiber quality from high-volume instrument (HVI) fibrogram to better predict yarn quality than the standard HVI output. The present invention allows for information on fiber quality to be obtained while avoiding testing samples with more expensive techniques. The disclosed system and method extracts HVI data for collecting a respective set of initial fibrograms from a set of fiber samples and representing them as a distance matrix to form a matrix of transformed fibrogram data, said matrix of transformed fibrogram data comprising a vector of scores to represent each sample and thereafter explaining variation in yarn quality by extracting all of the information available from the fibrogram.

Abstract: Disclosed herein are heterocyclic compounds that inhibit the binding of menin and MLL or MLL fusion proteins. Also described are specific inhibitors of menin-MLL interaction. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the menin-MLL inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, leukemia and other diseases or conditions dependent on menin-MLL interaction.

Abstract: Disclosed herein are heterocyclic compounds that inhibit the binding of menin and MLL or MLL fusion proteins. Also described are specific irreversible inhibitors of menin-MLL interaction. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the menin-MLL irreversible inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, leukemia and other diseases or conditions dependent on menin-MLL interaction.

Abstract: A cell mass dissociator for a pluripotent stem cell production system.

Abstract: The present invention provides a nerve cell production method that involves preparing stem cells and then introducing inducing-factor RNA into the stem cells and allowing differentiation into nerve cells. The present invention also provides a nerve cell production method that involves preparing cells, introducing reprogramming-factor RNA into the cells, introducing inducing-factor RNA into the cells into which the reprogramming-factor RNA was introduced, and allowing differentiation into nerve cells.

Abstract: A cell mass dissociator for a pluripotent stem cell production system.

Abstract: A warning light assembly for alerting drivers to a hazard includes a housing that defines an internal space. At least one battery is coupled to the housing and is positioned in the internal space. A spool is rotationally coupled to the housing. A tube is loopedly positioned around the spool. The tube is flexible and substantially transparent. A plurality of lights is coupled to and is positioned within the tube. The lights are operationally coupled to the at least one battery. A block is coupled to a respective opposing end of the tube. The block is configured to anchor the respective opposing end of the tube to a surface, such as a road. The tube is configured to selectively extend from the housing to a deployed configuration. The lights are configured to illuminate to warn persons proximate to the tube, such as drivers, of a hazard.

Abstract: Underdrain units in a sand medium or dual medium filtration system include efficient air, water and combined air/water cleaning. Air, water or both are delivered in backflow direction from a very low position on the underdrain unit, as well as water from a higher position, so as to effectively remove blocking contaminants on the outside the underdrain unit and in the surrounding filter media.

Abstract: The present invention provides a stem cell manufacturing system comprising: a sending channel (20) through which a solution containing cells flows; an apparatus (30) which is connected to the sending channel (20) and transfers a pluripotency inducer into the cells to produce cells harboring the inducer; and an apparatus (40) which cultures the cells harboring the inducer to produce cell clusters consisting of stem cells.

Abstract: A stem cell production system provided with a preintroduction cell-feeding solution channel 20 through which a solution containing cells passes, an induction factor-feeding solution mechanism 21 for feeding a pluripotency induction factor to the preintroduction cell-feeding solution channel 20, a factor introduction device 30 connected to the preintroduction cell-feeding solution channel 20 for making cells with induction factor introduced by introducing the pluripotency induction factor into the cells, a cell mass-making device 40 for making multiple cell masses comprising stem cells by culturing the cells with induction factor introduced, and a packaging device 100 for sequentially packaging each of the multiple cell masses.

Abstract: Underdrain units in a sand medium or dual medium filtration system include efficient air, water and combined air/water cleaning. Air, water or both are delivered in backflow direction from a very low position on the underdrain unit, as well as water from a higher position, so as to effectively remove blocking contaminants on the outside the underdrain unit and in the surrounding filter media.

Abstract: In an example embodiment, a system for displaying a product in a touch-sensitive display of a portable electronic device comprises at least one module, executing on one or more computer processors to present a graphical image representative of the product in the touch-sensitive display, detect a slide-based contact with the touch-sensitive display at or over a first predefined location corresponding to the product image in the display, and display, in response to the detection of the slide-based contact, an array of swatch images associated with variants of the product in the touch-sensitive display.

Abstract: In an example embodiment, a system for displaying a product in a touch-sensitive display of a portable electronic device comprises at least one module, executing on one or more computer processors to present a graphical image representative of the product in the touch-sensitive display, detect a slide-based contact with the touch-sensitive display at or over a first predefined location corresponding to the product image in the display, and display, in response to the detection of the slide-based contact, an array of swatch images associated with variants of the product in the touch-sensitive display.

Abstract: In an example embodiment, a system for displaying a product in a touch-sensitive display of a hand-held electronic device comprises at least one module, executing on one or more computer processors to present a graphical image representative of the product in the touch-sensitive display, detect a slide-based contact with the touch-sensitive display at or over a first predefined location corresponding to the product image in the display, and display, in response to the detection of the slide-based contact, an array of swatch images associated with variants of the product in the touch-sensitive display.

Abstract: The present disclosure is directed to a computer-implemented method for designing a supply chain for multiple objectives based on a supply chain model. The method comprises defining a plurality of objectives for the supply chain model. The supply chain model includes a plurality of edges connecting one or more demands with one or more supplies. The method further includes selecting a first one of the plurality of objectives and at least a second one of the plurality of objectives and configuring, using a controller, the supply chain model for the first objective. The method further comprises identifying, using the controller, a subset of the plurality of edges based on the supply chain model configured for the first objective and relationships between the plurality of edges and the at least second objective. The method further comprises operating the supply chain according to the identified subset of the plurality of edges.