Patents by Inventor Brendan Laurenzi
Brendan Laurenzi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230098083Abstract: A dry powder inhaler including replaceable cartridges containing a dry powder for local or systemic delivery through the pulmonary tract and lungs is disclosed. The inhalers are used with inhalable dry powders, including medicament formulations comprising active agents for local or systemic delivery and for the treatment of diseases such as, pulmonary hypertension, cardiovascular disease, anaphylaxis, diabetes, obesity, cancer, and other diseases, or symptoms associated with these and other diseases, such as nausea, vomiting, pain and inflammation.Type: ApplicationFiled: November 9, 2022Publication date: March 30, 2023Inventors: P. Spencer Kinsey, Brendan Laurenzi, Chad C. Smutney, Benoit Adamo, Joseph Guarneri, John J. Freeman, JR.
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Publication number: 20230001112Abstract: Described herein are an interactive apparatus and methods for sensing and measuring real-time characteristic patterns of a subject's use of a dry powder inhalation system. The inhaler device can be used in a wireless communication mode to communicate with a display to assess the subject's usage of the inhalation system concurrently as the inhalation is performed and thus the subject's inhalation can be evaluated as well as the performance of the inhalation system. The system can also detect the identity of the medicament, its dosage, lot, expiration, etc. and the characteristics profile of a dry powder formulation emitted from the inhalation system in use.Type: ApplicationFiled: September 9, 2022Publication date: January 5, 2023Inventors: John J. Pocreva, III, Benoit Adamo, Brendan Laurenzi, Chad C. Smutney, Spencer P. Kinsey
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Publication number: 20220370773Abstract: An apparatus includes a chamber container and a tray. The chamber container has a first portion and a second portion removably coupled to the first portion. The first and second portions collectively define an inner volume. The tray is configured to be removably disposed within the inner volume of the chamber container. The tray includes a first portion and a second portion coupled to the first portion via a hinge. The first portion includes a first retention surface. The second portion includes a second retention surface. The tray is configured to receive a biodiffusion chamber between the first portion and the second portion such that the first retention surface and the second retention surface engage a portion of the biodiffusion chamber to (1) place the biodiffusion chamber in a predetermined orientation and (2) maintain the biodiffusion chamber in a substantially fixed position relative to the tray.Type: ApplicationFiled: September 18, 2020Publication date: November 24, 2022Inventors: Douglas C. Hooper, Samantha Garcia, Rhonda Kean, Dominic Ventura, Brendan Laurenzi, David Gregory Honan
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Patent number: 11478591Abstract: Described herein are an interactive apparatus and methods for sensing and measuring real-time characteristic patterns of a subject's use of a dry powder inhalation system. The inhaler device can be used in a wireless communication mode to communicate with a display to assess the subject's usage of the inhalation system concurrently as the inhalation is performed and thus the subject's inhalation can be evaluated as well as the performance of the inhalation system. The system can also detect the identity of the medicament, its dosage, lot, expiration, etc. and the characteristics profile of a dry powder formulation emitted from the inhalation system in use.Type: GrantFiled: May 19, 2017Date of Patent: October 25, 2022Assignee: MannKind CorporationInventors: John J. Pocreva, III, Benoit Adamo, Brendan Laurenzi, Chad C. Smutney, Spencer P. Kinsey
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Publication number: 20210361888Abstract: Described herein are an interactive apparatus and methods for sensing and measuring real-time characteristic patterns of a subject's use of a dry powder inhalation system. The inhaler device can be used in a wireless communication mode to communicate with a display to assess the subject's usage of the inhalation system concurrently as the inhalation is performed and thus the subject's inhalation can be evaluated as well as the performance of the inhalation system. The system can also detect the identity of the medicament, its dosage, lot, expiration, etc. and the characteristic profile of a dry powder formulation emitted from the inhalation system in use and allows effective delivery of powder doses. Data obtained can be transmitted to a digital application and can be analyzed for optimal therapeutic utility.Type: ApplicationFiled: April 24, 2019Publication date: November 25, 2021Applicant: Mannkind CorporationInventors: John J. Pocreva, III, Benoit Adamo, Brendan Laurenzi, Chad C Smutney, P. Spencer Kinsey
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Publication number: 20210146071Abstract: A dry powder inhaler including replaceable cartridges containing a dry powder for local or systemic delivery through the pulmonary tract and lungs is disclosed. The inhalers are used with inhalable dry powders, including medicament formulations comprising active agents for local or systemic delivery and for the treatment of diseases such as, pulmonary hypertension, cardiovascular disease, anaphylaxis, diabetes, obesity, cancer, and other diseases, or symptoms associated with these and other diseases, such as nausea, vomiting, pain and inflammation.Type: ApplicationFiled: January 26, 2021Publication date: May 20, 2021Inventors: P. Spencer Kinsey, Brendan Laurenzi, Chad C. Smutney, Benoit Adamo, Joseph Guarneri, John J. Freeman, JR.
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Publication number: 20210052875Abstract: A biodiffusion chamber for performing autologous cell vaccination is provided. The biodiffusion chamber is adapted for insertion into and removal from a subject. In some embodiments, the biodiffusion chamber comprises (i) a chamber body defining a hollow cavity and including a first surface and a second surface, (ii) a first semi-permeable membrane coupled to the first surface, (iii) a second semi-permeable membrane coupled to the second surface, and (iv) an element and/or feature adapted for removing the biodiffusion chamber from the subject. The first semi-permeable membrane and the second semi-permeable membrane are permeable to fluids and soluble factors but are not permeable to cells.Type: ApplicationFiled: January 24, 2019Publication date: February 25, 2021Inventors: Brendan LAURENZI, David ANDREWS, William HITCHINGS, Dominic VENTURA, Kara PIGOTT, Douglas Craig Hooper
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Publication number: 20200046917Abstract: A dry powder inhaler including replaceable cartridges containing a dry powder for local or systemic delivery through the pulmonary tract and lungs is disclosed. The inhalers are used with inhalable dry powders, including medicament formulations comprising active agents for local or systemic delivery and for the treatment of diseases such as, pulmonary hypertension, cardiovascular disease, anaphylaxis, diabetes, obesity, cancer, and other diseases, or symptoms associated with these and other diseases, such as nausea, vomiting, pain and inflammation.Type: ApplicationFiled: October 14, 2019Publication date: February 13, 2020Inventors: P. Spencer Kinsey, Brendan Laurenzi, Chad C. Smutney, Benoit Adamo, Joseph Guarneri
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Publication number: 20190175847Abstract: Described herein are an interactive apparatus and methods for sensing and measuring real-time characteristic patterns of a subject's use of a dry powder inhalation system. The inhaler device can be used in a wireless communication mode to communicate with a display to assess the subject's usage of the inhalation system concurrently as the inhalation is performed and thus the subject's inhalation can be evaluated as well as the performance of the inhalation system. The system can also detect the identity of the medicament, its dosage, lot, expiration, etc. and the characteristics profile of a dry powder formulation emitted from the inhalation system in use.Type: ApplicationFiled: May 19, 2017Publication date: June 13, 2019Inventors: John J. POCREVA, III, Benoit Adamo, Brendan Laurenzi, Chad C. Smutney, Spencer P. Kinsey
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Publication number: 20170216538Abstract: A dry powder inhaler including replaceable cartridges containing a dry powder for local or systemic delivery through the pulmonary tract and lungs is disclosed. The inhalers are used with inhalable dry powders, including medicament formulations comprising active agents for local or systemic delivery and for the treatment of diseases such as, pulmonary hypertension, cardiovascular disease, anaphylaxis, diabetes, obesity, cancer, and other diseases, or symptoms associated with these and other diseases, such as nausea, vomiting, pain and inflammation.Type: ApplicationFiled: January 27, 2017Publication date: August 3, 2017Inventors: P. Spencer Kinsey, Brendan Laurenzi, Chad C. Smutney, Benoit Adamo, Joseph Guarneri
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Patent number: 9706944Abstract: An inhalation simulation system is provided for use with inhalers in particular breath-powered dry powder inhalers. The simulation system can recreate a patient's inhalation profile obtained with an inhaler adapted with a sensing and monitoring device for the detection of characteristic signals generated from the inhaler in use, which signals are transmitted to a computer with an algorithm which is configured to analyze the signals and generate new signals via a transmitter to actuate the inhalation simulation system component parts so that a subject's inhalation profile is replicated simultaneously or in real-time, or stored for later use. Methods of measuring the performance of inhalers are also provided.Type: GrantFiled: March 24, 2015Date of Patent: July 18, 2017Assignee: MannKind CorporationInventors: Benoit Adamo, John M. Polidoro, Dennis Overfield, Carl R. Sahi, Brendan Laurenzi, Chad C. Smutney, P. Spencer Kinsey
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Publication number: 20150196724Abstract: An inhalation simulation system is provided for use with inhalers in particular breath-powered dry powder inhalers. The simulation system can recreate a patient's inhalation profile obtained with an inhaler adapted with a sensing and monitoring device for the detection of characteristic signals generated from the inhaler in use, which signals are transmitted to a computer with an algorithm which is configured to analyze the signals and generate new signals via a transmitter to actuate the inhalation simulation system component parts so that a subject's inhalation profile is replicated simultaneously or in real-time, or stored for later use. Methods of measuring the performance of inhalers are also provided.Type: ApplicationFiled: March 24, 2015Publication date: July 16, 2015Inventors: Benoit Adamo, John M. Polidoro, Dennis Overfield, Carl R. Sahi, Brendan Laurenzi, Chad C. Smutney, P. Spencer Kinsey
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Patent number: 9016147Abstract: An inhalation simulation system is provided for use with inhalers in particular breath-powered dry powder inhalers. The simulation system can recreate a patient's inhalation profile obtained with an inhaler adapted with a sensing and monitoring device for the detection of characteristic signals generated from the inhaler in use, which signals are transmitted to a computer with an algorithm which is configured to analyze the signals and generate new signals via a transmitter to actuate the inhalation simulation system component parts so that a subject's inhalation profile is replicated simultaneously or in real-time, or stored for later use. Methods of measuring the performance of inhalers are also provided.Type: GrantFiled: November 3, 2010Date of Patent: April 28, 2015Assignee: MannKind CorporationInventors: Benoit Adamo, John M. Polidoro, Dennis Overfield, Carl R. Sahi, Brendan Laurenzi, Chad C. Smutney, Spencer P. Kinsey
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Publication number: 20120247235Abstract: An inhalation simulation system is provided for use with inhalers in particular breath-powered dry powder inhalers. The simulation system can recreate a patient's inhalation profile obtained with an inhaler adapted with a sensing and monitoring device for the detection of characteristic signals generated from the inhaler in use, which signals are transmitted to a computer with an algorithm which is configured to analyze the signals and generate new signals via a transmitter to actuate the inhalation simulation system component parts so that a subject's inhalation profile is replicated simultaneously or in real-time, or stored for later use. Methods of measuring the performance of inhalers are also provided.Type: ApplicationFiled: November 3, 2010Publication date: October 4, 2012Applicant: MANNKIND CORPORATIONInventors: Benoit Adamo, John M. Polidoro, Dennis Overfield, Carl R. Sahi, Brendan Laurenzi, Chad C. Smutney, Spencer P. Kinsey
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Patent number: D636867Type: GrantFiled: June 14, 2010Date of Patent: April 26, 2011Assignee: MannKind CorporationInventors: John M. Polidoro, Benoit Adamo, Brendan Laurenzi, P. Spencer Kinsey, Chad C. Smutney
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Patent number: D824015Type: GrantFiled: January 29, 2016Date of Patent: July 24, 2018Assignee: MannKind CorporationInventors: Benoit Adamo, P. Spencer Kinsey, Brendan Laurenzi
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Patent number: D824016Type: GrantFiled: January 29, 2016Date of Patent: July 24, 2018Assignee: MannKind CorporationInventors: P. Spencer Kinsey, Brendan Laurenzi, Chad C. Smutney, Benoit Adamo
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Patent number: D824510Type: GrantFiled: January 29, 2016Date of Patent: July 31, 2018Assignee: MannKind CorporationInventors: P. Spencer Kinsey, Brendan Laurenzi, Benoit Adamo
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Patent number: D834178Type: GrantFiled: May 19, 2017Date of Patent: November 20, 2018Assignee: MannKind CorporationInventors: P. Spencer Kinsey, Brendan Laurenzi, Benoit Adamo, Chad C. Smutney
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Patent number: D841798Type: GrantFiled: January 29, 2016Date of Patent: February 26, 2019Assignee: MannKind CorporationInventors: P. Spencer Kinsey, Brendan Laurenzi, Benoit Adamo