Abstract: The invention relates to compounds of Formula I, and pharmaceutically acceptable salts thereof, and methods of making and using the same. Certain compounds described herein are unexpectedly potent and more effective in inhibiting cancer cell proliferation that is driven, at least in part, by KRAS protein with a G12C mutation. Certain compounds are exceptionally suitable for use in methods of treating cancers mediated, in whole or in part, by KRAS G12C mutation, and the potency of the compounds offer certain advantages to effect therapeutic benefit.

Abstract: The present disclosure provides compounds, such as compounds of Formula I, and compositions that are MCL1 inhibitors.

Abstract: The invention relates to compounds of Formula I, and pharmaceutically acceptable salts thereof, and methods of making and using the same. The compounds of the invention are effective in inhibiting KRAS protein with a G12C mutation and are suitable for use in methods of treating cancers mediated, in whole or in part, by KRAS G12C mutation.

Abstract: The present disclosure describes compounds of formulas (I)-(V) and methods of making the same. The compounds of the present disclosure are useful as inhibitors of PRMT5 activity and in methods of treating cancers and other diseases.

Abstract: The present disclosure provides compounds and compositions that are CDK inhibitors selective for CDK4 and/or CDK6, and methods of use thereof.

Abstract: A gaming machine includes a cabinet having a main video display mounted on a front side of the cabinet. The gaming machine also includes at least one additional video display mounted on the front side of the cabinet either above or below the game video display. The player controls include a separate player control touch screen mounted on a deck projecting forwardly at the front side of the gaming machine cabinet, and facing upwardly to present reconfigurable player touch controls for the gaming machine. These controls may be reconfigured within a game or to change the game presentations on the machine in response to player commands or gaming network conditions.

Abstract: A gaming machine includes a cabinet having a main video display mounted on a front side of the cabinet. The gaming machine also includes at least one additional video display mounted on the front side of the cabinet either above or below the game video display. The player controls include a separate player control touch screen mounted on a deck projecting forwardly at the front side of the gaming machine cabinet, and facing upwardly to present reconfigurable player touch controls for the gaming machine. These controls may be reconfigured within a game or to change the game presentations on the machine in response to player commands or gaming network conditions.

Abstract: A method of implementing a circuit design in a circuit design tool for configuration in a programmable integrated circuit (IC) connected to components on a circuit board is described. The method includes processing a first file associated with the circuit board to obtain descriptions of circuit board interfaces of the components on the circuit board; displaying a graphic user interface (GUI) of the circuit design tool to connect a circuit board interface described in the first file with a circuit design interface in the circuit design; generating physical constraints on the circuit design interface with respect to input/outputs of the programmable IC described as being connected to the selected circuit board interface; and generating a bitstream to configure the programmable IC. The bitstream includes a physical implementation of the circuit design satisfying the physical constraints.

Abstract: A gaming machine includes a cabinet having a main video display mounted on a front side of the cabinet. The gaming machine also includes at least one more additional video display mounted on the front side of the cabinet either above or below the game video display. The player controls include a separate player control touch screen mounted on a ledge projecting forwardly from the front side of the gaming machine cabinet, and facing upward to present reconfigurable player touch controls for the gaming machine. These controls may be reconfigured within a game or to change the game presentation on the machine in response to player commands or gaming network conditions.

Abstract: The present invention provides a compound of the Formula I: (Formular I should be inserted here) or a pharmaceutically acceptable salt, solvate or ester thereof, wherein R, R1, R2 and R3 are as defined herein. The compounds are ERK inhibitors. Also disclosed are pharmaceutical compositions comprising the above compounds and methods of treating cancer using the same.

Abstract: An exemplary method of implementing a circuit design for a programmable integrated circuit (IC) includes, on at least one programmed processor, performing operations including: generating a description of circuit components of the circuit design including first portion of a circuit module that is independent of assignment of resources of the programmable IC; assigning a plurality of the resources of the programmable IC to a plurality of the circuit components including determining at least one resource assignment for the circuit module; and generating a physical implementation of the circuit components for implementation in the programmable IC, including generating a second portion of the circuit module that is dependent on the at least one resource assignment, and combining the second portion of the circuit module with the first portion of the circuit module.

Abstract: A method for conducting bingo games includes using a server to collect game play requests from a plurality of electronic player stations. The server determines if a group of the collected game play requests meets one or more predefined conditions for establishing a quorum, and if so conducts a game with the group of game play requests. Even after the game is started, the server continues to collect game play requests in preparation for conducting additional games. When enough game play requests are collected, the server starts the next game, even if previous games are still in progress.

Abstract: The present invention provides novel pyrimidine amines of formula (I) which are potent inhibitors of spleen tyrosine kinase, and are useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD and rheumatoid arthritis.

Abstract: A gaming machine includes a cabinet having a main video display mounted on a front side of the cabinet. The gaming machine also includes at least one more additional video display mounted on the front side of the cabinet either above or below the game video display. The player controls include a separate player control touch screen mounted on a ledge projecting forwardly from the front side of the gaming machine cabinet, and facing upward to present reconfigurable player touch controls for the gaming machine. These controls may be reconfigured within a game or to change the game presentation on the machine in response to player commands or gaming network conditions.

Abstract: A method is provided for exporting design constraints from a circuit design. In response to a first user command indicating a design constraint and a pattern, the design constraint is assigned to each object in the circuit design that matches the pattern, and the pattern is stored in a database. In response to a second user command to export design constraints of the circuit design, for each design constraint assigned to a respective set of objects of the circuit design, a pattern stored in the database that matches the respective set of the objects is determined and the design constraint is added to an export file in a format that uses the determined pattern. Design constraints on individual ones of the set of the objects indicated by the determined pattern are omitted from the export file.

Abstract: A method for conducting bingo games includes using a server to collect game play requests from a plurality of electronic player stations. The server determines if a group of the collected game play requests meets one or more predefined conditions for establishing a quorum, and if so conducts a game with the group of game play requests. Even after the game is started, the server continues to collect game play requests in preparation for conducting additional games. When enough game play requests are collected, the server starts the next game, even if previous games are still in progress.

Abstract: The present invention provides novel pyrimidine amines of formula (I) which are potent inhibitors of spleen tyrosine kinase, and are useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD and rheumatoid arthritis.

Abstract: A method for conducting bingo games includes using a server to collect game play requests from a plurality of electronic player stations. The server determines if a group of the collected game play requests meets one or more predefined conditions for establishing a quorum, and if so conducts a game with the group of game play requests. Even after the game is started, the server continues to collect game play requests in preparation for conducting additional games. When enough game play requests are collected, the server starts the next game, even if previous games are still in progress.

Abstract: The present invention provides a compound of the Formula I: (Formular I should be inserted here) or a pharmaceutically acceptable salt, solvate or ester thereof, wherein R, R1, R2 and R3 are as defined herein. The compounds are ERK inhibitors. Also disclosed are pharmaceutical compositions comprising the above compounds and methods of treating cancer using the same.

Abstract: The present invention provides novel pyrimidine amines of formula (I) which are potent inhibitors of spleen tyrosine kinase, and are useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD and rheumatoid arthritis.