Patents by Inventor Brendan Mack

Brendan Mack has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Hepatitis C virus inhibitors
    Patent number: 10494400
    Abstract: The present disclosure relates to methods for making asunaprevir, useful treatment of Hepatitis C virus (HCV) infection, and its intermediates.
    Type: Grant
    Filed: June 23, 2015
    Date of Patent: December 3, 2019
    Assignee: Bristol-Myers Squibb Company
    Inventors: Scott A. Savage, Nathan R. Domagalski, Brendan Mack, Purushotham Vemishetti, Yuping Qiu, Michael Fenster, Daniel M. Hallow, Glenn Ferreira, Amanda Rogers, Sha Lou, Lindsay Hobson
  • HEPATITIS C VIRUS INHIBITORS
    Publication number: 20180155393
    Abstract: The present disclosure relates to methods for making asunaprevir, useful treatment of Hepatitis C virus (HCV) infection, and its intermediates.
    Type: Application
    Filed: June 23, 2015
    Publication date: June 7, 2018
    Inventors: Scott A. SAVAGE, Nathan R. DOMAGALSKI, Brendan MACK, Purushotham VEMISHETTI, Yuping QIU, Michael FENSTER, Daniel M. HALLOW, Glenn FERREIRA, Amanda ROGERS, Sha LOU, Lindsay HOBSON
  • Biodegradable drug-polymer delivery system
    Patent number: 8128954
    Abstract: A sustained-release biodegradable polymeric drug-eluting fiber is disclosed. In some embodiments, the therapeutic drug is complexed with cyclodextrin. In certain embodiments, the polymeric component of the fiber comprises cyclodextrin. The fiber may be fabricated to provide a thread and/or suture. The fiber may be used for treatment of ocular diseases or disorders.
    Type: Grant
    Filed: June 7, 2005
    Date of Patent: March 6, 2012
    Assignee: California Institute of Technology
    Inventors: Mark E. Davis, Kenneth W. Wright, Brendan Mack
  • Paracorporeal respiratory assist lung
    Publication number: 20070020142
    Abstract: A paracorporeal respiratory assist lung is configured with an annular cylindrical hollow fiber membrane (fiber bundle) that is rotated at rapidly varying speeds. Fluid (for example, blood) is introduced to the center of the device and is passed radially through the fiber bundle. The bundle is rotated at rapidly changing velocities with a rotational actuator (for example, a motor or magnetic coupling). The rotation of the fiber bundle provides centrifugal kinetic energy to the fluid giving the device pumping capabilities and may create Taylor vortexes to increase mass transfer. Rotation of the fiber bundle increases the relative velocity between the fluid and the hollow fibers and increases the mass transfer. The porosity of the fiber bundle may be varied to enhance gas exchange with the blood. Alternatively, a rotating core may be used with a stationary fiber bundle.
    Type: Application
    Filed: April 21, 2006
    Publication date: January 25, 2007
    Inventors: William Federspiel, Brian Frankowski, Brendan Mack, Scott Morley, Meir Rosenberg, Robert Svitek
  • Biodegradable drug-polymer delivery system
    Publication number: 20050276841
    Abstract: A sustained-release biodegradable polymeric drug-eluting fiber is disclosed. In some embodiments, the therapeutic drug is complexed with cyclodextrin. In certain embodiments, the polymeric component of the fiber comprises cyclodextrin. The fiber may be fabricated to provide a thread and/or suture. The fiber may be used for treatment of ocular diseases or disorders.
    Type: Application
    Filed: June 7, 2005
    Publication date: December 15, 2005
    Applicant: California Institute of Technology
    Inventors: Mark Davis, Kenneth Wright, Brendan Mack