Abstract: In some embodiments, a method of manufacturing a metabolic sensor includes assembling a working wire for a metabolic sensor and exposing the interference layer to an oxidizing agent such as a gas. The assembly comprises forming an interference layer on a substrate, the substrate having an electrically conductive surface; forming an enzyme layer on the interference layer; and forming a glucose limiting layer on the enzyme layer. The exposing is performed prior to sterilizing the working wire.

Abstract: The present invention provides wound healing or wound care polymer compositions that can be formulated to release a wound healing agent at a controlled rate by adjusting the various components of the composition. The compositiona can be used in an external wound dressing, as a polymer implant for delivery of the wound healing agent to an internal body site, or as a coating on the surface of an implantable surgical device to deliver wound healing agents that are dispersed in a biodegradable polymer or hydrogel, or both. Methods of using the invention bioactive polymer compositions to deliver wound healing agents that promote natural healing of wounds, especially chronic wounds, are also provided.

Abstract: The present invention provides bioactive polymer compositions that can be formulated to release a wound healing agent at a controlled rate by adjusting the various components of the composition. The composition can be used in an external wound dressing, as a polymer implant for delivery of the wound healing agent to an internal body site, or as a coating on the surface of an implantable surgical device to deliver wound healing agents that are covalently attached to a biocompatible, biodegradable polymer and/or embedded within a hydrogel. Methods of using the invention bioactive polymer compositions to promote natural healing of wounds, especially chronic wounds, are also provided.

Abstract: Systems and methods for direct execution of domain models are provided. According to one embodiment, a software runtime engine directly executes an executable high-level modeling language that employs non-procedural programming constructs that can substitute for procedural constructs.

Abstract: An inflatable article of furniture (100) includes at least two inflatable mattresses (1, 2), a hinge (5), and at least one tube (3, 4) positioned external to the hinge. The hinge connects the two mattresses together and is adapted to permit rotation of at least one of the inflatable mattresses relative to the other. The tube(s) permits passage of an inflating substance between the first inflatable mattress and the second inflatable mattress such that both mattresses may be rapidly inflated in a single step upon introducing an inflating substance into one of the mattresses. The article of furniture may optionally include a backrest (8) and one or more armrests (9, 10) that are fixedly connected to one of the mattresses and integrally connected together to facilitate use of the article of furniture in several different configurations.

Abstract: The present invention provides a computer system engineering methodology. The present invention uses an approach to engineering computer systems that includes a requirements workflow, an architectural workflow, a realization workflow, a validation workflow, and a project management workflow.