Patents by Inventor Brendan Smith

Brendan Smith has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Combination therapy for the treatment of immunoinflammatory disorders
    Publication number: 20070110685
    Abstract: The invention features a method for treating a patient diagnosed with, or at risk of developing, an immunoinflammatory disorder by administering a non-steroidal immunophilin-dependent immunosuppressant (NsIDI) and a Group A enhancer (e.g., antifungal agent, antigout agent, anti-infective agent, antiprotozoal agent, antiviral agent, humectant, sunscreen, vitamin D compound, microtubuline inhibitor, or zinc salt) or analog or metabolite thereof to the patient. The invention also features a pharmaceutical composition containing an NsIDI and Group A enhancer or analog or metabolite thereof for the treatment or prevention of an immunoinflammatory disorder.
    Type: Application
    Filed: June 16, 2006
    Publication date: May 17, 2007
    Inventors: Benjamin Auspitz, Bradley Brasher, Todd Chappell, Michael Frank, Daniel Grau, Edward Jost-Price, Seth Lederman, Palaniyandi Manivasakam, Seth Orlow, Noah Sachs, Brendan Smith
  • Methods and reagents for the treatment of immunoinflammatory disorders
    Publication number: 20070010502
    Abstract: The invention features a method for treating a patient diagnosed with, or at risk of developing, an immunoinflammatory disorder by administering to the patient a tetra-substituted pyrimidopyrimidine, either alone or in combination with one or more additional agents. The invention also features a composition containing a tetra-substituted pyrimidopyrimidine in combination with one or more additional agents.
    Type: Application
    Filed: September 7, 2006
    Publication date: January 11, 2007
    Applicant: CombinatoRx Inc.
    Inventors: Curtis Keith, Alexis Borisy, Grant Zimmermann, Edward Jost-Price, Palaniyandi Manivasakam, Nicole Hurst, Michael Foley, Michael Slavonic, Brendan Smith, Benjamin Auspitz
  • Methods and reagents for the treatment of immunoinflammatory disorders
    Publication number: 20050192261
    Abstract: The invention features a method for treating a patient diagnosed with, or at risk of developing, an immunoinflammatory disorder by administering to the patient an antihistamine, either alone or in combination with one or more additional agents. The invention also features a pharmaceutical composition containing an antihistamine in combination with one or more additional agents.
    Type: Application
    Filed: September 14, 2004
    Publication date: September 1, 2005
    Inventors: Edward Jost-Price, Palaniyandi Manivasakam, Bradley Brasher, Brendan Smith, Noah Sachs, Benjamin Auspitz, Todd Chappell, Micheal Slavonic
  • Methods and reagents for the treatment of inflammatory disorders
    Publication number: 20050187203
    Abstract: The invention features a method for treating an immunoinflammatory administering a compound of formula (I), e.g., ibudilast or KC-764, alone or in combination with a corticosteroid, tetra-substituted pyrimidopyrimidine, or other compound. The invention also features pharmaceutical compositions including the combination above for the treatment or prevention of an immunoinflammatory disorder.
    Type: Application
    Filed: November 19, 2004
    Publication date: August 25, 2005
    Inventors: Edward Jost-Price, Palaniyandi Manivasakam, Brendan Smith, Michael Slavonic, Benjamin Auspitz
  • Methods and reagents for the treatment of inflammatory disorders
    Publication number: 20050187200
    Abstract: The invention features a method for treating a patient diagnosed with, or at risk of developing, an immunoinflammatory disorder by administering a tricyclic compound and, optionally, a corticosteroid or other compound to the patient. The invention also features a pharmaceutical composition containing a tricyclic compound and a corticosteroid or other compound for the treatment or prevention of an immunoinflammatory disorder.
    Type: Application
    Filed: November 12, 2004
    Publication date: August 25, 2005
    Inventors: Benjamin Auspitz, Alexis Borisy, Jason Fong, Nicole Hurst, Edward Jost-Price, Curtis Keith, Palaniyandi Manivasakam, Robyn Sackeyfio, Michael Slavonic, Brendan Smith, Grant Zimmermann
  • Method and device
    Publication number: 20050171506
    Abstract: The invention relates to a method and device for treating or preventing or suppressing a disease or condition in a non-human animal. The method comprises the steps of providing a single delivery device containing two components for sequential delivery from the delivery device. A first component is delivered from the single delivery device into a teat canal of a non-human animal and subsequently the second component is delivered from the single delivery device into the teat canal. The components are delivered without substantial mixing of the components.
    Type: Application
    Filed: February 2, 2005
    Publication date: August 4, 2005
    Inventors: Stephen Hallahan, Nicholas McHardy, Brendan Smith, Louis Van Vessem
  • Methods and reagents for the treatment of diseases and disorders associated with increased levels of proinflammatory cytokines
    Publication number: 20050153947
    Abstract: The invention features a method for treating a patient diagnosed with, or at risk of developing, an immunoinflammatory disorder by administering an SSRI or analog or metabolite thereof and, optionally, a corticosteroid or other compound to the patient. The invention also features a pharmaceutical composition containing an SSRI or analog or metabolite thereof and a corticosteroid or other compound for the treatment or prevention of an immunoinflammatory disorder.
    Type: Application
    Filed: September 20, 2004
    Publication date: July 14, 2005
    Inventors: Mahesh Padval, Edward Jost-Price, Palaniyandi Manivasakam, Brendan Smith, Jason Fong, Benjamin Auspitz, M. Nichols, Curtis Keith, Grant Zimmerman, Bradley Brasher, Noah Sachs, Todd Chappell
  • Methods and reagents for the treatment of immunoinflammatory disorders
    Publication number: 20050119160
    Abstract: The invention features a method for treating a patient diagnosed with, or at risk of developing, an immunoinflammatory disorder by administering to the patient a tetra-substituted pyrimidopyrimidine, either alone or in combination with one or more additional agents. The invention also features a composition containing a tetra-substituted pyrimidopyrimidine in combination with one or more additional agents.
    Type: Application
    Filed: October 15, 2004
    Publication date: June 2, 2005
    Inventors: Curtis Keith, Alexis Borisy, Grant Zimmermann, Edward Jost-Price, Palaniyandi Manivasakam, Nicole Hurst, Michael Foley, Michael Slavonic, Brendan Smith, Benjamin Auspitz
  • Methods and reagents for the treatment of diseases and disorders associated with increased levels of proinflammatory cytokines
    Publication number: 20040229849
    Abstract: The invention features a method for treating a patient diagnosed with, or at risk of developing, an immunoinflammatory disorder by administering an SSRI or analog or metabolite thereof and, optionally, a corticosteroid or other compound to the patient. The invention also features a pharmaceutical composition containing an SSRI or analog or metabolite thereof and a corticosteroid or other compound for the treatment or prevention of an immunoinflammatory disorder.
    Type: Application
    Filed: February 12, 2004
    Publication date: November 18, 2004
    Inventors: Edward Roydon Jost-Price, Palaniyandi Manivasakam, Brendan Smith, Jason Fong, Benjamin A. Auspitz, M. James Nichols, Curtis Keith, Grant R. Zimmermann, Bradley B. Brasher, Noah Sachs, Todd W. Chappell
  • Combination therapy for the treatment of immunoinflammatory disorders
    Publication number: 20040224876
    Abstract: The invention features a method for treating a patient diagnosed with, or at risk of developing, an immunoinflammatory disorder by administering a non-steroidal immunophilin-dependent immunosuppressant (NsIDI) and an NsIDI enhancer (NsIDIE) or analog or metabolite thereof to the patient. The invention also features a pharmaceutical composition containing an NsIDI and NsIDIE or analog or metabolite thereof for the treatment or prevention of an immunoinflammatory disorder.
    Type: Application
    Filed: February 12, 2004
    Publication date: November 11, 2004
    Inventors: Edward Roydon Jost-Price, Bradley B. Brasher, Todd W. Chappell, Palaniyandi Manivasakam, Noah Sachs, Brendan Smith, Benjamin A. Auspitz
  • Methods and reagents for the treatment of diseases and disorders associated with increased levels of proinflammatory cytokines
    Publication number: 20040220153
    Abstract: The invention features a method for treating a patient diagnosed with, or at risk of developing, an immunoinflammatory disorder by administering an SSRI or analog or metabolite thereof and, optionally, a corticosteroid or other compound to the patient. The invention also features a pharmaceutical composition containing an SSRI or analog or metabolite thereof and a corticosteroid or other compound for the treatment or prevention of an immunoinflammatory disorder.
    Type: Application
    Filed: September 24, 2003
    Publication date: November 4, 2004
    Inventors: Edward Roydon Jost-Price, Palaniyandi Manivasakam, Brendan Smith, Jason Fong, Benjamin A. Auspitz, M. James Nichols, Curtis Keith, Grant R. Zimmermann, Bradley B. Brasher, Noah Sachs, Todd W. Chappell