Abstract: A process is described for producing an isohexide wherein an hexitol or a combination of hexitols is continuously dehydrated in the presence of an acid catalyst under vacuum using a thin film evaporator.

Abstract: Methods are disclosed relating to generating a silene-free slide comprising the steps of providing a plastic substrate; providing a solution of acrylamide comprising N-(5-bromoacetamidylpentyl) acrylamide (BRAPA); contacting the acrylamide/BRAPA solution with a polymerizing agent; contacting the acrylamide/BRAPA solution with an oxidizing agent; and contacting the acrylamide/BRAPA/polymerizing agent/oxidizing agent to the plastic substrate.

Abstract: Methods are disclosed relating to localizing nucleic acids to arrays such as silane-free arrays, and of sequencing the nucleic acids localized thereby.

Abstract: The present invention relates to a linker for forming conjugates of a protein or peptide with a therapeutically active agent and which comprise a thiomaleamic acid moiety that is susceptible to cleavage under the pH conditions prevalent in the lysosome.

Abstract: Methods are disclosed relating to localizing nucleic acids to arrays such as silane-free arrays, and of sequencing the nucleic acids localized thereby.

Abstract: A composition including (a) a solid support having a surface; (b) a first plurality of nucleic acids immobilized on the surface, wherein the nucleic acids in the first plurality each include the P7 primer sequence (5?-CAAGCAGAAGACGGCATACGA-3?; SEQ ID NO: 3); and (c) a second plurality of nucleic acids immobilized on the surface, wherein the nucleic acids in the second plurality each include the P5 primer sequence (5?-AATGATACGGCGACCACCGA-3?; SEQ ID NO: 4).

Abstract: A polyetherimide having an OH content that is greater than 0 and equal or less than 100 ppm; a Relative Thermal Index that is greater than or equal to 170° C.; and a chlorine content that is greater than 0 ppm is disclosed herein. A method for preparing the polyetherimide is also disclosed.

Abstract: A composition including (a) a solid support having a surface; (b) a first plurality of nucleic acids immobilized on the surface, wherein the nucleic acids in the first plurality each include the P7 primer sequence (5?-CAAGCAGAAGACGGCATACGA-3?); and (c) a second plurality of nucleic acids immobilized on the surface, wherein the nucleic acids in the second plurality each include the P5 primer sequence (5?-AATGATACGGCGACCACCGA-3?).

Abstract: A polyetherimide having an OH content that is greater than 0 and equal or less than 100 ppm; a Relative Thermal Index that is greater than or equal to 170° C.; and a chlorine content that is greater than 0 ppm is disclosed herein. A method for preparing the polyetherimide is also disclosed.

Abstract: The invention relates to the preparation of a hydrogel surface useful in the formation and manipulation of arrays of molecules, particularly polynucleotides and to the chemical modification of these and other arrays. In particular, the invention relates to a method of preparing a hydrogel immobilised to a solid support comprising polymerising on the support a mixture of a first comonomer which is acrylamide, methacrylamide, hydroxyethyl methacrylate or N-vinyl pyrrolidinone and a second comonomer which is a functionalised acrylamide or acrylate.

Abstract: A core-shell particle including a core with poly(arylene ether) and a shell with an ethylenically unsaturated copolymer is described. Also described are a method of forming the particle, a composition including the particle, and an article including such a composition.

Abstract: A vulcanizable rubber composition including an unsaturated rubber, core-shell particles, and a vulcanizing agent is described. The core-shell particles include a core with poly(arylene ether) and a shell with an ethylenically unsaturated copolymer. Also described are a vulcanized rubber composition and an article that includes it.

Abstract: A rubber comprising a silane, a filler and at least one rubber selected from the group consisting of solution polymerization-derived styrene-butadiene rubber (S-SBR) having from about 10 to about 80 percent vinyl content; (ii) emulsion polymerization-derived rubber; and (iii) butadiene rubber having from about 5 to about 99 percent cis content and from about 0 to about 60 percent vinyl content.

Abstract: A core-shell particle including a core with poly(arylene ether) and a shell with an ethylenically unsaturated copolymer is described. Also described are a method of forming the particle, a composition including the particle, and an article including such a composition.

Abstract: A vulcanizable rubber composition including an unsaturated rubber, core-shell particles, and a vulcanizing agent is described. The core-shell particles include a core with poly(arylene ether) and a shell with an ethylenically unsaturated copolymer. Also described are a vulcanized rubber composition and an article that includes it.

Abstract: A composition is provided that may include a sulfur-functional linear polyorganosiloxane. The sulfur-functional linear polyorganosiloxane may include a chemically protected sulfur group. Under certain conditions, the sulfur group may react with an unsaturated elastomer. The invention may include embodiments that relate to method of making and using the sulfur-functional linear polyorganosiloxane.

Abstract: A composition is provided for use with an unsaturated elastomer. The composition may include a sulfur-functional linear polyorganosiloxane. The sulfur-functional linear polyorganosiloxane may include a chemically protected sulfur group. Under certain conditions, the sulfur group may react with the unsaturated elastomer. The invention includes embodiments that may relate to methods of making and using the sulfur-functional linear polyorganosiloxane in elastomer compositions.

Abstract: A rubber comprising a silane, a filler and at least one rubber selected from the group consisting of solution polymerization-derived styrene-butadiene rubber (S-SBR) having from about 10 to about 80 percent vinyl content; (ii) emulsion polymerization-derived rubber; and (iii) butadiene rubber having from about 5 to about 99 percent cis content and from about 0 to about 60 percent vinyl content.

Abstract: 3,4-Disubstituted-1-cyclopentene compounds, in substantially enantiopure form, have the relative stereochemistry according to formula (1A) or (1B) including the opposite enantiomers thereof, wherein R1 is either COOX, wherein X is selected from the group consisting of alkyl, H, and a salt-forming cation, or CH2OH, whererin the hydroxy group is optionally protected; R2 is H or a protecting group; R3 is H or alkyl, and R4 is selected from the group consisting of H, alkoxy, alkyl, aryl, and aralkyl; or, in the case of formula (1A), R2 and R4 are linked to form an oxazolidonone ring. These compounds can be used to prepare a series of complementary stereochemcially varied cyclopentane scaffolds.