Patents by Inventor Brent A. Appleton

Brent A. Appleton has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Crystal structures of neuropilin fragments and neuropilin-antibody complexes
    Patent number: 8466264
    Abstract: The invention provides crystal structures of neuropilin 1 (Nrp1) and neuropilin 2 (Nrp2) fragments alone and in complex with anti-neuropilin antibodies, and method for their use. The invention further provides anti-Nrp antibodies and methods for their therapeutic applications.
    Type: Grant
    Filed: July 3, 2012
    Date of Patent: June 18, 2013
    Assignee: Genentech, Inc.
    Inventors: Brent A. Appleton, Christian Wiesmann, Yan Wu
  • CRYSTAL STRUCTURES OF NEUROPILIN FRAGMENTS AND NEUROPILIN-ANTIBODY COMPLEXES
    Publication number: 20120322989
    Abstract: The invention provides crystal structures of neuropilin 1 (Nrp1) and neuropilin 2 (Nrp2) fragments alone and in complex with anti-neuropilin antibodies, and method for their use. The invention further provides anti-Nrp antibodies and methods for their therapeutic applications.
    Type: Application
    Filed: July 3, 2012
    Publication date: December 20, 2012
    Inventors: Brent A. APPLETON, Christian Wiesmann, Yan Wu
  • Anti-pan neuropilin antibody and binding fragments thereof
    Patent number: 8318163
    Abstract: The invention provides crystal structures of neuropilin 1 (Nrp1) and neuropilin 2 (Nrp2) fragments alone and in complex with anti-neuropilin antibodies, and method for their use. The invention further provides anti-Nrp antibodies and methods for their therapeutic applications.
    Type: Grant
    Filed: May 17, 2007
    Date of Patent: November 27, 2012
    Assignee: Genentech, Inc.
    Inventors: Brent A. Appleton, Christian Wiesmann, Yan Wu
  • CRYSTAL STRUCTURES OF NEUROPILIN FRAGMENTS AND NEUROPILIN-ANTIBODY COMPLEXES
    Publication number: 20100150919
    Abstract: The invention provides crystal structures of neuropilin 1 (Nrp1) and neuropilin 2 (Nrp2) fragments alone and in complex with anti-neuropilin antibodies, and method for their use. The invention further provides anti-Nrp antibodies and methods for their therapeutic applications.
    Type: Application
    Filed: May 17, 2007
    Publication date: June 17, 2010
    Inventors: Brent A. Appleton, Christian Wiesmann, Yan Wu