Abstract: A method for developing stratified medicine for nonalcoholic fatty liver disease (NAFLD includes obtaining a microphysiological system (MPS) comprising a liver tissue cytoarchitecture, adipose tissue, or both. The method includes inducing metabolic dysfunction representing NAFLD in the liver or adipose tissue of the MPS. The method includes generating, based on inducing the metabolic dysfunction, transcriptomics data for the MPS. The method includes applying a drug to the MPS using a dosing regimen. The method includes monitoring changes in the transcriptomics data based on applying the drug. The method includes generating a model relating the changes in the transcriptomics data to the dosing regimen of the drug.

Abstract: Embodiments are directed to identifying intermittent faults in a unit under test (UUT), and to mapping interconnections between connection points in a UUT. In one scenario, a testing apparatus includes an interface for electrically attaching the UUT to a testing module and an input circuit for supplying an individual stimulus signal to each unpowered connection point in the UUT. The testing apparatus also includes an active intermittence detecting circuit electronically connected to each connecting point in the UUT. A stimulus signal is applied simultaneously to each connecting line, so that an intermittent fault on any line will generate a trigger on those connection lines that have an intermittent fault. The testing apparatus also includes a logic circuit that determines when a trigger has been generated on the UUT, determines the connection point of the trigger, assigns a timestamp to the intermittent fault, and generates reporting data for the intermittent fault.

Abstract: Embodiments are directed to identifying intermittent faults in a unit under test (UUT), and to mapping interconnections between connection points in a UUT. In one scenario, a testing apparatus includes an interface for electrically attaching the UUT to a testing module and an input circuit for supplying an individual stimulus signal to each unpowered connection point in the UUT. The testing apparatus also includes an active intermittence detecting circuit electronically connected to each connecting point in the UUT. A stimulus signal is applied simultaneously to each connecting line, so that an intermittent fault on any line will generate a trigger on those connection lines that have an intermittent fault. The testing apparatus also includes a logic circuit that determines when a trigger has been generated on the UUT, determines the connection point of the trigger, assigns a timestamp to the intermittent fault, and generates reporting data for the intermittent fault.

Abstract: An apparatus for testing connections in a system has a plurality of inputs each adapted to couple to a test point in the system under test and a switching module. The switching module includes a first output selectively coupled to receive a first group of one or more of the inputs and a set of outputs corresponding in number to the plurality of inputs, each being selectively coupled to receive a corresponding one of the plurality of inputs. The apparatus may also include a meter coupled to the first switching module output and an array of nodes coupled to the set of switching module outputs, where each node couples a signal to a row sense line and a column sense line.

Abstract: An apparatus for testing connections in a system has a plurality of inputs each adapted to couple to a test point in the system under test and a switching module. The switching module includes a first output selectively coupled to receive a first group of one or more of the inputs and a set of outputs corresponding in number to the plurality of inputs, each being selectively coupled to receive a corresponding one of the plurality of inputs. The apparatus may also include a meter coupled to the first switching module output and an array of nodes coupled to the set of switching module outputs, where each node couples a signal to a row sense line and a column sense line.

Abstract: A latching tester for testing continuity of wires in a system has an array of pin electronics cells, where each pin cell couples a signal to a row sense line and a column sense line when a change in current flow through a pin occurs; apparatus for detecting the signal on the row sense line; and apparatus for detecting the signal on the column sense line. The array of pin electronics cells may also operate as a capacitively coupled neural network, where a signal coupled onto the row and column lines from a stimulus line varies with the load on each pin of the pin electronics cells. An alternate mode of operation permits stimulus of the network and attached loads, and generation of a signature based upon the response of the network to the stimulus, as observed on the row and column sense lines. In yet another mode of operation, the tester may serve to recognize particular signals.