Abstract: This disclosure describes compositions and methods involved in tumor suppression and inhibiting infection of cells by pathogens. Generally, the compositions include an mRNA cargo that can provide a therapeutic benefit after being introduced into an epithelial cell. In some cases, the mRNA can encode a polypeptide. In some cases, the polypeptide can suppress epithelial cell proliferation. In other embodiments, the polypeptide can be involved in innate immunity. In various embodiments, the polypeptide can include cathelicin antimicrobial protein (CAMP), calprotectin, S100A8, S100A9, a ?-defensin, S100A7, secretory leukocyte inhibitor, lipocalin 2, or lysozyme. In some embodiments, the mRNA can include a stabilizing moiety such as, for example, a 5? cap or a 3? extension.

Abstract: Embodiments include an aircraft comprising a fuselage; a wing connected to the fuselage; and first and second propulsion systems connected to the wing on opposite sides of the fuselage, wherein at least a portion of each of the first and second propulsion systems and at least a portion of the wing are tiltable between a first position in which the aircraft is in a hover mode and a second position in which the aircraft is in a cruise mode, wherein each of the propulsion systems includes pylon and a rotor assembly comprising a plurality of rotor blades.

Abstract: There is disclosed in one example a tiltrotor system for a vertical takeoff and landing (VTOL) aircraft, including: a rotor pylon, wherein the rotor pylon is rotatable, via a rotation maneuver, between a substantially horizontal orientation and a substantially vertical orientation; a linear actuator disposed to actuate the rotation maneuver; and a mechanical guide disposed to maintain a center of gravity along a substantially linear axis throughout the rotation maneuver.

Abstract: Embodiments include an aircraft comprising a fuselage; a wing connected to the fuselage; and first and second propulsion systems connected to the wing on opposite sides of the fuselage, wherein at least a portion of each of the first and second propulsion systems and at least a portion of the wing are tiltable between a first position in which the aircraft is in a hover mode and a second position in which the aircraft is in a cruise mode, wherein each of the propulsion systems includes pylon and a rotor assembly comprising a plurality of rotor blades.

Abstract: A vertical takeoff and landing (VTOL) aircraft, including: a vehicle controller circuit programmed to operate the VTOL aircraft without an onboard human operator; a rotor system; an airframe; and an external cargo coupling to receive an external payload of at least approximately 300 pounds beneath the airframe.

Abstract: There is disclosed in one example a tiltrotor system for a vertical takeoff and landing (VTOL) aircraft, including: a rotor pylon, wherein the rotor pylon is rotatable, via a rotation maneuver, between a substantially horizontal orientation and a substantially vertical orientation; a linear actuator disposed to actuate the rotation maneuver; and a mechanical guide disposed to maintain a center of gravity along a substantially linear axis throughout the rotation maneuver.

Abstract: Embodiments include an aircraft comprising a fuselage; a wing connected to the fuselage; and first and second propulsion systems connected to the wing on opposite sides of the fuselage, wherein at least a portion of each of the first and second propulsion systems and at least a portion of the wing are tiltable between a first position in which the aircraft is in a hover mode and a second position in which the aircraft is in a cruise mode, wherein each of the propulsion systems includes pylon and a rotor assembly comprising a plurality of rotor blades.

Abstract: One embodiment is an aircraft including a fuselage; a wing connected to the fuselage; first and second booms connected to the wing on opposite sides of the fuselage; first and second forward propulsion systems attached to forward ends of the first and second booms; first and second aft propulsion systems fixedly attached proximate aft ends of the first and second booms; and first and second wing-mounted propulsion systems connected to outboard ends of wings; wherein the first and second wing-mounted propulsion systems are tiltable between a first position when the aircraft is in a hover mode and a second position when the aircraft is in a cruise mode.

Abstract: One embodiment is an aircraft including a fuselage; a wing connected to the fuselage; first and second booms connected to the wing on opposite sides of the fuselage; first and second forward propulsion systems attached to forward ends of the first and second booms; first and second aft propulsion systems fixedly attached proximate aft ends of the first and second booms; first and second wing-mounted propulsion systems connected to outboard ends of wings; and first and second wing tips fixedly connected to outboard sides of the first and second wing-mounted propulsion systems; wherein the first and second wing-mounted propulsion systems and the first and second wing tips are collectively tiltable between a first position when the aircraft is in a hover mode and a second position when the aircraft is in a cruise mode.

Abstract: An aircraft is described and includes a fuselage, a wing coupled to the fuselage, and a rotor system including a proprotor system and an engine. An interconnect driveshaft gear is configured to communicate mechanical energy between a gearbox and an interconnect driveshaft. An accessory gear is coplanar with and in mechanical communication with the driveshaft gear. A proprotor gear is coplanar with and in mechanical communication with the interconnect driveshaft gear and the accessory gear and communicates mechanical energy to the proprotor system. An engine gear coplanar and in mechanical communication with the interconnect driveshaft ear, the accessory gear, and the proprotor gear transmits mechanical energy to the proprotor system via the proprotor gear.

Abstract: An aircraft including a nacelle disposed at a fixed location relative a wing member; a proprotor housing coupled to the nacelle, the proprotor housing configured to selectively rotate between a horizontal orientation and a non-horizontal orientation; a door pivotably coupled to the proprotor housing; and a linkage to connect the door and the nacelle, the linkage configured to move with the door from a closed position when the proprotor housing is in a horizontal orientation to an open position when the proprotor housing is in a non-horizontal orientation. In some embodiments, there can be a hinge member for hingedly coupling the door to the proprotor and/or nacelle. In other embodiments, the door includes a flexure portion. In some embodiments, the nacelle includes a plurality of doors. In other embodiments, proprotor includes a forward portion and a stationary aft portion; wherein the forward portion is configured to selectively pivot.

Abstract: A method for facilitating the design and manufacturing of a tiltrotor aircraft, including the steps of: determining a compatible mission data set; identifying lift propulsion module components for the compatible mission data set; determining compatible specifications; and generating a design for a lift propulsion module; wherein the lift propulsion module is configured to be connected to at least two different fuselages. There is also a method of designing a tiltrotor aircraft, comprising the step of modularizing a lift propulsion system, wherein the lift propulsion system is configured to be connected to at least two different fuselages. In another aspect, there is a tiltrotor aircraft including a fuselage; and a lift propulsion module, the lift propulsion module including a mounting surface; wherein the lift propulsion module is coupled to the fuselage on the mounting surface. Also included are methods of assembling and systems including a lift propulsion module.

Abstract: An aircraft is described and includes a fuselage, a wing coupled to the fuselage, and a rotor system including a proprotor system and an engine. An interconnect driveshaft gear is configured to communicate mechanical energy between a gearbox and an interconnect driveshaft. An accessory gear is coplanar with and in mechanical communication with the driveshaft gear. A proprotor gear is coplanar with and in mechanical communication with the interconnect driveshaft gear and the accessory gear and communicates mechanical energy to the proprotor system. An engine gear coplanar and in mechanical communication with the interconnect driveshaft ear, the accessory gear, and the proprotor gear transmits mechanical energy to the proprotor system via the proprotor gear.

Abstract: A method for facilitating the design and manufacturing of a tiltrotor aircraft, including the steps of: determining a compatible mission data set; identifying lift propulsion module components for the compatible mission data set; determining compatible specifications; and generating a design for a lift propulsion module; wherein the lift propulsion module is configured to be connected to at least two different fuselages. There is also a method of designing a tiltrotor aircraft, comprising the step of modularizing a lift propulsion system, wherein the lift propulsion system is configured to be connected to at least two different fuselages. In another aspect, there is a tiltrotor aircraft including a fuselage; and a lift propulsion module, the lift propulsion module including a mounting surface; wherein the lift propulsion module is coupled to the fuselage on the mounting surface. Also included are methods of assembling and systems including a lift propulsion module.

Abstract: An aircraft is described and includes a fuselage, a wing coupled to the fuselage, and a rotor system including a proprotor system and an engine. An interconnect driveshaft gear is configured to communicate mechanical energy between a gearbox and an interconnect driveshaft. An accessory gear is coplanar with and in mechanical communication with the driveshaft gear. A proprotor gear is coplanar with and in mechanical communication with the interconnect driveshaft gear and the accessory gear and communicates mechanical energy to the proprotor system. An engine gear coplanar and in mechanical communication with the interconnect driveshaft ear, the accessory gear, and the proprotor gear transmits mechanical energy to the proprotor system via the proprotor gear.

Abstract: An aircraft including a nacelle disposed at a fixed location relative a wing member; a proprotor housing coupled to the nacelle, the proprotor housing configured to selectively rotate between a horizontal orientation and a non-horizontal orientation; a door pivotably coupled to the proprotor housing; and a linkage to connect the door and the nacelle, the linkage configured to move with the door from a closed position when the proprotor housing is in a horizontal orientation to an open position when the proprotor housing is in a non-horizontal orientation. In some embodiments, there can be a hinge member for hingedly coupling the door to the proprotor and/or nacelle. In other embodiments, the door includes a flexure portion. In some embodiments, the nacelle includes a plurality of doors. In other embodiments, proprotor includes a forward portion and a stationary aft portion; wherein the forward portion is configured to selectively pivot.

Abstract: A method for applying adhesive to sides of a flange, such as in rotorcraft connection joints, includes attaching an intermediate member to an edge of a flange and flowing adhesive in gaps between sides of the flange and inner edges of a double lap joint element by inserting the flange with the intermediate member into the double lap joint element.

Abstract: According to one embodiment, an aircraft features a fuselage, a wing coupled to the fuselage, and a first rotor system. The first rotor system includes a first proprotor system and a first engine. The first proprotor system is coupled proximate to a first wing tip of the wing and is tiltable between a helicopter mode position and an airplane mode position. The first engine is in mechanical communication with the first proprotor system and coupled above the wing, outboard of the fuselage and inboard of the first pylon.

Abstract: In some embodiments, an aircraft may include a retractable or extendable landing gear. The landing gear may include a wheel connected to an axle, a strut configured to resist longitudinal compression, and a linear actuator that is partially disposed within an opening of the strut.

Abstract: In some embodiments, an aircraft may include a retractable or extendable landing gear. The landing gear may include a wheel connected to an axle, a strut configured to resist longitudinal compression, and a linear actuator that is partially disposed within an opening of the strut.