Patents by Inventor Brent E. STEAD

Brent E. STEAD has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • LIPID-ENCAPSULATED DUAL-CLEAVING ENDONUCLEASE FOR DNA AND GENE EDITING
    Publication number: 20260098248
    Abstract: Methods to edit genes by administering a chimeric nuclease to a cell or organism without the use of a viral vector.
    Type: Application
    Filed: October 10, 2025
    Publication date: April 9, 2026
    Inventors: David R. EDGELL, Thomas A. MCMURROUGH, Brent E. STEAD, Odisho K. ISRAEL
  • Lipid-encapsulated dual-cleaving endonuclease for DNA and gene editing
    Patent number: 12460192
    Abstract: Disclosed herein are methods to edit genes, for example by administering a chimeric nuclease to a cell or organism without the use of a viral vector. Some methods herein include editing DNA of a cell by contacting the cell with a nuclease comprising a Cas9 sequence, where the nuclease edits the DNA of the cell.
    Type: Grant
    Filed: April 21, 2025
    Date of Patent: November 4, 2025
    Assignee: Specific Biologics Inc.
    Inventors: David R. Edgell, Thomas A. McMurrough, Brent E. Stead, Odisho K. Israel
  • LIPID-ENCAPSULATED DUAL-CLEAVING ENDONUCLEASE FOR DNA AND GENE EDITING
    Publication number: 20250297238
    Abstract: Methods to edit genes by administering a chimeric nuclease to a cell or organism without the use of a viral vector.
    Type: Application
    Filed: April 21, 2025
    Publication date: September 25, 2025
    Inventors: David R. EDGELL, Thomas A. MCMURROUGH, Brent E. STEAD, Odisho K. ISRAEL
  • Lipid-encapsulated dual-cleaving endonuclease for DNA and gene editing
    Patent number: 12312615
    Abstract: Provided herein are modified Staphylococcus aureus Cas9 nucleases and methods of using modified Staphylococcus aureus Cas9 nucleases. Also provided herein are chimeric nucleases comprising an I-Tevl nuclease domain, and a Staphylococcus aureus Cas9 and methods of using the chimeric nuclease. Also provided herein are methods to edit genes by administering a chimeric nuclease to a cell or organism without the use of a viral vector.
    Type: Grant
    Filed: October 29, 2021
    Date of Patent: May 27, 2025
    Assignee: SPECIFIC BIOLOGICS INC.
    Inventors: David R. Edgell, Thomas A. McMurrough, Brent E. Stead, Odisho K. Israel
  • Lipid-encapsulated dual-cleaving endonuclease for DNA and gene editing
    Patent number: 12297467
    Abstract: Methods to edit genes by administering a chimeric nuclease to a cell or organism without the use of a viral vector.
    Type: Grant
    Filed: June 22, 2022
    Date of Patent: May 13, 2025
    Assignee: SPECIFIC BIOLOGICS INC.
    Inventors: David R. Edgell, Thomas A. McMurrough, Brent E. Stead, Odisho K. Israel
  • TARGETING ONCOGENIC MUTATIONS WITH DUAL-CLEAVING ENDONUCLEASE
    Publication number: 20240360427
    Abstract: Provided herein are compositions and methods of using chimeric nucleases comprising an I-TevI nuclease domain and a Cas domain for the targeting of oncogenes.
    Type: Application
    Filed: September 22, 2023
    Publication date: October 31, 2024
    Inventor: Brent E. STEAD
  • GENE EDITING WITH A MODIFIED ENDONUCLEASE
    Publication number: 20240150796
    Abstract: An engineered nuclease with unique binding and cleavage properties and methods to alter cellular gene expression using said modified endonucleases for gene editing.
    Type: Application
    Filed: May 2, 2023
    Publication date: May 9, 2024
    Inventors: Brent E. STEAD, Thomas A. MCMURROUGH, Odisho K. ISRAEL
  • Lipid-encapsulated dual-cleaving endonuclease for DNA and gene editing
    Patent number: 11814658
    Abstract: Methods to edit genes by administering a chimeric nuclease to a cell or organism without the use of a viral vector.
    Type: Grant
    Filed: November 15, 2022
    Date of Patent: November 14, 2023
    Assignee: Specific Biologics Inc.
    Inventors: David R. Edgell, Thomas A. McMurrough, Brent E. Stead, Odisho K. Israel
  • LIPID-ENCAPSULATED DUAL-CLEAVING ENDONUCLEASE FOR DNA GENE EDITING
    Publication number: 20230203464
    Abstract: Methods to edit genes by administering a chimeric nuclease to a cell or organism without the use of a viral vector.
    Type: Application
    Filed: November 15, 2022
    Publication date: June 29, 2023
    Inventors: David R. EDGELL, Thomas A. MCCMURROUGH, Brent E. STEAD, Odisho K. ISRAEL
  • LIPID-ENCAPSULATED DUAL-CLEAVING ENDONUCLEASE FOR DNA GENE EDITING
    Publication number: 20230016280
    Abstract: Methods to edit genes by administering a chimeric nuclease to a cell or organism without the use of a viral vector.
    Type: Application
    Filed: June 22, 2022
    Publication date: January 19, 2023
    Inventors: David R. EDGELL, Thomas A. MCCMURROUGH, Brent E. STEAD, Odisho K. ISRAEL
  • LIPID-ENCAPSULATED DUAL-CLEAVING ENDONUCLEASE FOR DNA AND GENE EDITING
    Publication number: 20220195404
    Abstract: Methods to edit genes by administering a chimeric nuclease to a cell or organism without the use of a viral vector.
    Type: Application
    Filed: October 29, 2021
    Publication date: June 23, 2022
    Inventors: David R. EDGELL, Thomas A. MCMURROUGH, Brent E. STEAD, Odisho K. ISRAEL