Patents by Inventor Brent L. Kreider

Brent L. Kreider has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Myeloid progenitor inhibitory factor-1 (MPIF-1) polypeptides
    Patent number: 7851596
    Abstract: There are disclosed therapeutic compositions and methods using isolated nucleic acid molecules encoding a human myeloid progenitor inhibitory factor-1 (MPIF-1) polypeptide (previously termed MIP-3 and chemokine ?8 (CK?8 or ckb-8)); a human monocyte-colony inhibitory factor (M-CIF) polypeptide (previously termed MIP1-? and chemokine ?1 (CK?1 or ckb-1)), and a macrophage inhibitory protein-4 (MIP-4), as well as MPIF-1, M-CIF and/or MIP-4 polypeptides themselves, as are vectors, host cells and recombinant methods for producing the same.
    Type: Grant
    Filed: April 28, 2008
    Date of Patent: December 14, 2010
    Assignee: Human Genome Sciences, Inc.
    Inventors: Reiner L. Gentz, Brent L. Kreider, Jun Zhang, Michael Antonaccio, Donna Mendrick, Pablo Jimenez, Vikram Patel, Craig A. Rosen, Mark D. Adams, Haodong Li, Steven M. Ruben
  • Antibodies to chemokine ?-15
    Patent number: 7829293
    Abstract: The present invention concerns a member of the human chemokine CC protein family. In particular, isolated nucleic acid molecules are provided encoding the chemokine ?-15 protein. Chemokine ?-15 polypeptides are also provided. The invention further concerns diagnostic methods for detecting thymus disorders and therapeutic methods for modulating bone marrow cell proliferation and differentiation.
    Type: Grant
    Filed: October 2, 2006
    Date of Patent: November 9, 2010
    Assignee: Human Genome Sciences, Inc.
    Inventors: Ying-Fei Wei, Brent L. Kreider, Craig A. Rosen
  • Leukocyte Adhesion Inhibitor-1 (LAI-1)
    Publication number: 20090036370
    Abstract: There are disclosed therapeutic compositions and methods using isolated nucleic acid molecules encoding a human chemokine beta-11 (Ck beta-11) polypeptide and a human leukocyte adhesion inhibitor-1 (LAI-1) polypeptide (previously termed chemokine ?1 (CK?1 or cka-1), as well as Ck beta-11 and/or LAI-1 polypeptides themselves, as are vectors, host cells and recombinant methods for producing the same.
    Type: Application
    Filed: February 11, 2008
    Publication date: February 5, 2009
    Applicant: Human Genome Sciences, Inc.
    Inventors: Haodong Li, Brent L. Kreider
  • Myeloid Progenitor Inhibitory Factor-1 (MPIF-1), Monocyte Colony Inhibitory Factor (M-CIF), and Macrophage Inhibitory Factor-4 (MIP-4)
    Publication number: 20080274109
    Abstract: There are disclosed therapeutic compositions and methods using isolated nucleic acid molecules encoding a human myeloid progenitor inhibitory factor-1 (MPIF-1) polypeptide (previously termed MIP-3 and chemokine ?8 (CK?8 or ckb-8)); a human monocyte-colony inhibitory factor (M-CIF) polypeptide (previously termed MIP1-? and chemokine ?1 (CK?1 or ckb-1)), and a macrophage inhibitory protein-4 (MIP-4), as well as MPIF-1, M-CIF and/or MIP-4 polypeptides themselves, as are vectors, host cells and recombinant methods for producing the same.
    Type: Application
    Filed: April 28, 2008
    Publication date: November 6, 2008
    Applicant: Human Genome Sciences, Inc.
    Inventors: Reiner L. Gentz, Brent L. Kreider, Jun Zhang, Michael Antonaccio, Donna Mendrick, Pablo Jimenez, Vikram Patel, Craig A. Rosen, Mark D. Adams, Haodong Li, Steven M. Ruben
  • Antibodies to myeloid progenitor inhibitory factor-1 (MPIF-1)
    Patent number: 7364865
    Abstract: There are disclosed therapeutic compositions and methods using isolated nucleic acid molecules encoding a human myeloid progenitor inhibitory factor-1 (MPIF-1) polypeptide (previously termed MIP-3 and chemokine ?8 (CK?8 or ckb-8)); a human monocyte-colony inhibitory factor (M-CIF) polypeptide (previously termed MIP1-? and chemokine ?1(CK?1 or ckb-1)), and a macrophage inhibitory protein-4 (MIP-4), as well as MPIF-1, M-CIF and/or MIP-4 polypeptides themselves, as are vectors, host cells and recombinant methods for producing the same.
    Type: Grant
    Filed: May 5, 2006
    Date of Patent: April 29, 2008
    Assignee: Human Genome Sciences, Inc.
    Inventors: Reiner L. Gentz, Brent L. Kreider, Jun Zhang, Michael Antonaccio, Donna Mendrick, Pablo Jimenez, Vikram Patel, Craig A. Rosen, Mark D. Adams, Haodong Li, Steven M. Ruben
  • Polynucleotides encoding leukocyte adhesion inhibitor-1 (LAI-1)
    Patent number: 7332302
    Abstract: There are disclosed therapeutic compositions and methods using isolated nucleic acid molecules encoding a human chemokine beta-11 (Ck beta-11) polypeptide and a human leukocyte adhesion inhibitor-1 (LAI-1) polypeptide (previously termed chemokine ?1 (CK?1 or CKa-1), a well as Ck beta-11 and/or LAI-1 polypeptides themselves, as are vectors, host cells and recombinant methods for producing the same.
    Type: Grant
    Filed: October 12, 2005
    Date of Patent: February 19, 2008
    Assignee: Human Genome Sciences, Inc.
    Inventors: Haodong Li, Brent L. Kreider
  • Chemokine ?-15
    Patent number: 7135551
    Abstract: The present invention concerns a member of the human chemokine CC protein family. In particular, isolated nucleic acid molecules are provided encoding the chemokine ?-15 protein. Chemokine ?-15 polypeptides are also provided. The invention further concerns diagnostic methods for detecting thymus disorders and therapeutic methods for modulating bone marrow cell proliferation and differentiation.
    Type: Grant
    Filed: October 4, 2002
    Date of Patent: November 14, 2006
    Assignee: Human Genome Sciences, Inc.
    Inventors: Ying-Fei Wei, Brent L Kreider, Craig A Rosen
  • Antibodies to monocyte-colony inhibitory factor (M-CIF)
    Patent number: 7041460
    Abstract: There are disclosed therapeutic compositions and methods using isolated nucleic acid molecules encoding a human myeloid progenitor inhibitory factor-1 (MPIF-1) polypeptide (previously termed MIP-3 and chemokine ?8 (CK?8 or ckb-8)); a human monocyte-colony inhibitory factor (M-CIF) polypeptide (previously termed MIP1-? and chemokine ?1 (CK?1 or ckb-1)), and a macrophage inhibitory protein-4 (MIP-4), as well as MPIF-1, M-CIF and/or MIP-4 polypeptides themselves, as are vectors, host cells and recombinant methods for producing the same.
    Type: Grant
    Filed: July 25, 2003
    Date of Patent: May 9, 2006
    Assignee: Human Genome Sciences, Inc.
    Inventors: Reiner L. Gentz, Brent L. Kreider, Jun Zhang, Michael Antonaccio, Donna Mendrick, Pablo Jimenez, Vikram Patel, Craig A. Rosen, Mark D. Adams, Haodong Li, Steven M. Ruben
  • Methods of using chemokine beta-6
    Patent number: 6815420
    Abstract: Human chemokine &bgr;-6 agonist and antagonist polypeptides and DNA encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques are disclosed. The chemokine &bgr;-6 antagonists of the present invention may be employed to treat rheumatoid arthritis, lung inflammation, allergy, asmtha, infectious diseases and to prevent inflammation and atherosclerosis. The chemokine &bgr;-6 agonists may be employed to myeloprotect patients undergoing chemotherapy.
    Type: Grant
    Filed: January 25, 2002
    Date of Patent: November 9, 2004
    Assignee: Human Genome Sciences, INC
    Inventors: Brent L. Kreider, Steven M. Ruben, Henrik S Olsen
  • Human monocyte colony inhibitory factor (M-CIF) polypeptides
    Patent number: 6811773
    Abstract: There are disclosed therapeutic compositions and methods using a human monocyte-colony inhibitory factor (M-CIF) polypeptide (previously termed MIP1-&ggr; chemokine &bgr;1(CK&bgr;1 or ckb-1)), as well as ioslated nucleic acid molecules encoding M-CIF, and vectors, host cells and recombinant methods for producing the same.
    Type: Grant
    Filed: May 15, 2000
    Date of Patent: November 2, 2004
    Assignee: Human Genome Sciences, Inc.
    Inventors: Reiner L. Gentz, Brent L. Kreider, Jun Zhang, Michael Antonaccio, Donna Mendrick, Pablo Jimenez, Vikram Patel, Craig A. Rosen, Mark D. Adams, Haodong Li, Steven M. Ruben
  • Novel chemokine for mobilizing stem cells
    Publication number: 20040156822
    Abstract: Novel chemokines for mobilizing stem cells are provided. Methods of mobilizing stem cells are also provided.
    Type: Application
    Filed: March 19, 2004
    Publication date: August 12, 2004
    Applicants: Human Genome Sciences, Inc., SmithKline Beecham Corp.
    Inventors: John R. White, Louis Pelus, Haodong Li, Brent L. Kreider
  • Therapeutic compositions and methods for treating disease states with myeloid progenitor inhibitory factor-1 (MPIF-1), monocyte colony inhibitory factor (M-CIF), and macrophage inhibitory factor-4 (MIP-4)
    Publication number: 20040152169
    Abstract: There are disclosed therapeutic compositions and methods using isolated nucleic acid molecules encoding a human myeloid progenitor inhibitory factor-1 (MPIF-1) polypeptide (previously termed MIP-3 and chemokine &bgr;8 (CK&bgr;8 or ckb-8)); a human monocyte-colony inhibitory factor (M-CIF) polypeptide (previously termed MIP1-&ggr; and chemokine &bgr;1 (CK&bgr;1 or ckb-1)), and a macrophage inhibitory protein-4 (MIP-4), as well as MPIF-1, M-CIF and/or MIP-4 polypeptides themselves, as are vectors, host cells and recombinant methods for producing the same.
    Type: Application
    Filed: July 25, 2003
    Publication date: August 5, 2004
    Applicant: Human Genome Sciences, Inc.
    Inventors: Reiner L. Gentz, Brent L. Kreider, Jun Zhang, Michael Antonaccio, Donna Mendrick, Pablo Jimenez, Vikram Patel, Craig A. Rosen, Mark D. Adams, Haodong Li, Steven M. Ruben
  • Therapeutic compositions and methods for treating disease states with leukocyte adhesion inhibitor-1 (LAI-1), and chemokine beta-11 (Ck beta-11)
    Publication number: 20030082770
    Abstract: There are disclosed therapeutic compositions and methods using isolated nucleic acid molecules encoding a human chemokine beta-11 (Ck beta-11) polypeptide and a human leukocyte adhesion inhibitor-1 (LA11) polypeptide (previously termed chemokine &agr;1(CK&agr;1 or cka-1), as well as Ck beta-11 and/or LAI-1 polypeptides themselves, as are vectors, host cells and recombinant methods for producing the same.
    Type: Application
    Filed: September 20, 2002
    Publication date: May 1, 2003
    Applicant: Human Genome Sciences, Inc.
    Inventors: Haodong Li, Brent L. Kreider
  • Chemokine beta-15
    Publication number: 20030073198
    Abstract: The present invention concerns a member of the human chemokine CC protein family. In particular, isolated nucleic acid molecules are provided encoding the chemokine &bgr;-15 protein. Chemokine &bgr;-15 polypeptides are also provided. The invention further concerns diagnostic methods for detecting thymus disorders and therapeutic methods for modulating bone marrow cell proliferation and differentiation.
    Type: Application
    Filed: October 4, 2002
    Publication date: April 17, 2003
    Applicant: Human Genome Sciences, Inc.
    Inventors: Ying-Fei Wei, Brent L. Kreider, Craig A. Rosen
  • Methods of using chemokine B-6
    Publication number: 20030059874
    Abstract: Human chemokine &bgr;-6 agonist and antagonist polypeptides and DNA encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques are disclosed. The chemokine &bgr;-6 antagonists of the present invention may be employed to treat rheumatoid arthritis, lung inflammation, allergy, asmtha, infectious diseases and to prevent inflammation and atherosclerosis. The chemokine &bgr;-6 agonists may be employed to myeloprotect patients undergoing chemotherapy.
    Type: Application
    Filed: January 25, 2002
    Publication date: March 27, 2003
    Applicant: Human Genome Sciences, Inc.
    Inventors: Brent L. Kreider, Steven M. Ruben, Henrik S. Olsen
  • Polynucleotides encoding chemokine &bgr;-15
    Patent number: 6503735
    Abstract: The present invention concerns a member of the human chemokine CC protein family. In particular, isolated nucleic acid molecules are provided encoding the chemokine &bgr;-15 protein. Chemokine &bgr;-15 polypeptides are also provided. The invention further concerns diagnostic methods for detecting thymus disorders and therapeutic methods for modulating bone marrow cell proliferation and differentiation.
    Type: Grant
    Filed: March 19, 1999
    Date of Patent: January 7, 2003
    Assignee: Human Genome Sciences, Inc.
    Inventors: Ying-Fei Wei, Brent L. Kreider, Craig A. Rosen
  • Methods for inhibiting angiogenesis with leukocyte adhesion inhibitor-1 (LAI-1) polypeptides
    Patent number: 6485719
    Abstract: There are disclosed therapeutic compositions and methods using isolated nucleic acid molecules encoding a human chemokine beta-11 (Ck beta-11) polypeptide and a human leukocyte adhesion inhibitor-1 (LAI-1) polypeptide (previously termed chemokine &agr;1(CK&agr;1 or cka-1), as well as Ck beta-11 and/or LAI-1 polypeptides themselves, as are vectors, host cells and recombinant methods for producing the same.
    Type: Grant
    Filed: August 11, 2000
    Date of Patent: November 26, 2002
    Assignee: Human Genome Sciences, Inc.
    Inventors: Haodong Li, Brent L. Kreider
  • Polynucleotides encoding chemokine &bgr;-6 antagonists
    Patent number: 6379926
    Abstract: Human chemokine &bgr;-6 agonist and antagonist polypeptides and DNA encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques are disclosed. The chemokine &bgr;-6 antagonists of the present invention may be employed to treat rheumatoid arthritis, lung inflammation, allergy, asmtha, infectious diseases and to prevent inflammation and atherosclerosis. The chemokine &bgr;-6 agonists may be employed to myeloprotect patients undergoing chemotherapy.
    Type: Grant
    Filed: October 15, 1999
    Date of Patent: April 30, 2002
    Assignee: Human Genome Sciences, Inc.
    Inventors: Brent L. Kreider, Steven M. Ruben, Henrik S. Olsen
  • POLYNUCLEOTIDES ENCODING CHEMOKINE BETA-15
    Publication number: 20020019033
    Abstract: The present invention concerns a member of the human chemokine CC protein family. In particular, isolated nucleic acid molecules are provided encoding the chemokine &bgr;-15 protein. Chemokine &bgr;-15 polypeptides are also provided. The invention further concerns diagnostic methods for detecting thymus disorders and therapeutic methods for modulating bone marrow cell proliferation and differentiation.
    Type: Application
    Filed: March 19, 1999
    Publication date: February 14, 2002
    Inventors: YING-FEI WEI, BRENT L. KREIDER, CRAIG A. ROSEN
  • Leukocyte adhesion inhibitor-1 (LAI-1) Polypeptides
    Patent number: 6139832
    Abstract: There are disclosed therapeutic compositions and methods using isolated nucleic acid molecules encoding a human chemokine beta-11 (Ck beta-11) polypeptide and a human leukocyte adhesion inhibitor-1 (LAI-1) polypeptide (previously termed chemokine .alpha.1(CK.alpha.1 or ck.alpha.-1), as well as Ck beta-11 and/or LAI-1 polypeptides themselves, as are vectors, host cells and recombinant methods for producing the same.
    Type: Grant
    Filed: October 3, 1997
    Date of Patent: October 31, 2000
    Assignee: Human Genome Sciences, Inc.
    Inventors: Haodong Li, Brent L. Kreider