Patents by Inventor Brent L. Podlogar

Brent L. Podlogar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS FOR IDENTIFYING AND USING MarR FAMILY POLYPEPTIDE BINDING COMPOUNDS
    Publication number: 20120209003
    Abstract: Methods for identifying MarR family inhibiting compounds are described. The methods include the use of computer aided rational based drug design programs and three dimensional structures of MarR family polypeptides.
    Type: Application
    Filed: September 9, 2011
    Publication date: August 16, 2012
    Applicant: Paratek Pharmaceuticals, Inc.
    Inventors: Michael N. Alekshun, Stuart B. Levy, Brent L. Podlogar, Roger Frechette
  • Methods for identifying and using MarR family polypeptide binding compounds
    Patent number: 8039221
    Abstract: Methods for identifying MarR family inhibiting compounds are described. The methods include the use of computer aided rational based drug design programs and three dimensional structures of MarR family polypeptides.
    Type: Grant
    Filed: June 18, 2009
    Date of Patent: October 18, 2011
    Assignee: Paratek Pharmaceuticals, Inc.
    Inventors: Michael N. Alekshun, Stuart B. Levy, Brent L. Podlogar, Roger Frechette
  • TRANSCRIPTION FACTOR MODULATING COMPOUNDS AND METHODS OF USE THEREOF
    Publication number: 20110230523
    Abstract: Substituted benzoimidazole compounds useful as anti-infectives that decrease resistance, virulence, or growth of microbes are provided. Methods of making and using substituted benzoimidazole compounds, as well as pharmaceutical preparations thereof, in, e.g., reducing antibiotic resistance and inhibiting biofilms.
    Type: Application
    Filed: August 6, 2009
    Publication date: September 22, 2011
    Applicant: Paratek Pharmaceuticals, Inc.
    Inventors: Stuart B. LEVY, Michael N. ALEKSHUN, Brent L. PODLOGAR, Kwasi OHEMENG, Atul K. VERMA, Tadeusz WARCHOL, Beena BHATIA, Todd BOWSER, Mark GRIER
  • Methods for Identifying and Using MarR Family Polypeptide Binding Compounds
    Publication number: 20110015375
    Abstract: Methods for identifying MarR family inhibiting compounds are described. The methods include the use of computer aided rational based drug design programs and three dimensional structures of MarR family polypeptides.
    Type: Application
    Filed: June 18, 2009
    Publication date: January 20, 2011
    Applicant: Paratek Pharmaceuticals, Inc.
    Inventors: Michael N. Alekshun, Stuart B. Levy, Brent L. Podlogar, Roger Frechette
  • Transcription factor modulating compounds and methods of use thereof
    Publication number: 20090131401
    Abstract: Substituted benzoimidazole compounds useful as anti-infectives that decrease resistance, virulence, or growth of microbes are provided. Methods of making and using substituted benzoimidazole compounds, as well as pharmaceutical preparations thereof, in, e.g., reducing antibiotic resistance and inhibiting biofilms.
    Type: Application
    Filed: February 12, 2008
    Publication date: May 21, 2009
    Applicant: Paratek Pharmaceuticals, Inc.
    Inventors: Stuart B. Levy, Michael N. Alekshun, Brent L. Podlogar, Kwasi Ohemeng, Atul K. Verma, Tadeusz Warchol, Beena Bhatia, Todd Bowser, Mark Grier
  • Transcription factor modulating compounds and methods of use thereof
    Patent number: 7405235
    Abstract: Substituted benzoimidazole compounds useful as anti-infectives that decrease resistance, virulence, or growth of microbes are provided. Methods of making and using substituted benzoimidazole compounds, as well as pharmaceutical preparations thereof, in, e.g., reducing antibiotic resistance and inhibiting biofilms.
    Type: Grant
    Filed: November 3, 2003
    Date of Patent: July 29, 2008
    Assignee: Paratek Pharmaceuticals, Inc.
    Inventors: Stuart B. Levy, Michael N. Alekshun, Brent L. Podlogar, Kwasi Ohemeng, Atul K. Verma, Tadeusz Warchol, Beena Bhatia, Todd Bowser, Mark Grier
  • Methods for identifying and using MarR family polypeptide binding compounds
    Patent number: 7075582
    Abstract: Methods for identifying MarR family inhibiting compounds are described. The methods include the use of computer aided rational based drug design programs and three dimensional structures of MarR family polypeptides.
    Type: Grant
    Filed: July 15, 2002
    Date of Patent: July 11, 2006
    Assignee: Paratek Pharmaceuticals, Inc.
    Inventors: Michael N. Alekshun, Stuart B. Levy, Brent L. Podlogar, Roger Frechette
  • Preparation and use of 1,5,6,7-tetrahydropyrrolo[3,2-c]pyridine derivatives for treatment of obesity
    Patent number: 7071207
    Abstract: This invention relates to 1,5,6,7-tetrahydropyrrolo[3,2-c]pyridine derivatives which have been found to suppress appetite and induce weight loss. The invention also provides methods for synthesis of the compounds, pharmaceutical compositions comprising the compounds, and methods of using such compositions for inducing weight loss and treating obesity and obesity-related disorders.
    Type: Grant
    Filed: September 24, 2002
    Date of Patent: July 4, 2006
    Assignee: Bayer Pharmaceuticals Corporation
    Inventors: Roger A. Smith, Stephen J. O'Connor, Wai C. Wong, Soongyu Choi, Harold C. Kluender, Jianmei Fan, Zhonghua Zhang, Rico C. Lavoie, Brent L. Podlogar
  • Preparation and use of 1,5,6,7-tetrahydropyrrolo[3,2-c]pyridine derivatives for treatment of obesity
    Publication number: 20040224970
    Abstract: This invention relates to 1,5,6,7-tetrahydropyrrolo[3,2-c]pyridine derivatives which have been found to suppress appetite and induce weight loss. The invention also provides methods for synthesis of the compounds, pharmaceutical compositions comprising the compounds, and methods of using such compositions for inducing weight loss and treating obesity and obesity-related disorders.
    Type: Application
    Filed: February 27, 2004
    Publication date: November 11, 2004
    Inventors: Roger A Smith, Stephen J. O'Connor, Wai C. Wong, Soongyu Choi, Harold C.E. Kluender, Jianmei Fan, Zhonghua Zhang, Rico C. Lavoie, Brent L. Podlogar
  • Transcription factor modulating compounds and methods of use thereof
    Publication number: 20030229065
    Abstract: Methods for identifying compound useful as anti-infectives that decrease resistance, virulence, or growth of microbes are provided. In one embodiment, the method comprises contacting a microbial cell comprising: 1) a selectable marker under the control of a transcription factor responsive element and 2) a transcription factor, with a compound under conditions which allow interaction of the compound with the microbial cell; and measuring the ability of the compound to affect the growth or survival of the microbial cell as an indication of whether the test compound modulates the activity of a transcription factor.
    Type: Application
    Filed: August 14, 2002
    Publication date: December 11, 2003
    Inventors: Stuart B. Levy, Michael N. Alekshun, Brent L. Podlogar, Kwasi Ohemeng, Atul K. Verma, Tadeusz Warchol, Beena Bhatia
  • Methods for identifying and using MarR family polypeptide binding compounds
    Publication number: 20030215873
    Abstract: Methods for identifying MarR family inhibiting compounds are described. The methods include the use of computer aided rational based drug design programs and three dimensional structures of MarR family polypeptides.
    Type: Application
    Filed: July 15, 2002
    Publication date: November 20, 2003
    Inventors: Michael N. Alekshun, Stuart B. Levy, Brent L. Podlogar, Roger Frechette
  • Computational method for determining oral bioavailability
    Publication number: 20030069721
    Abstract: A method for determining oral bioavailibility based on the linear regression computer program, SIMCA (Soft Independent Modelling of Class Analogy) is described.
    Type: Application
    Filed: September 10, 2002
    Publication date: April 10, 2003
    Applicant: Paratek Pharmaceuticals, Inc.
    Inventor: Brent L. Podlogar
  • Macrocyclic difluorostatone derivatives useful as antiviral agents
    Patent number: 5969132
    Abstract: The present invention provides novel macrocyclic difluorostatone derivatives which are useful as antiviral agents. More specifically, these novel compounds are useful as inhibitors of retroviral proteases required for replication, particularly the HIV-1 and HIV-2 viral proteases, in the prevention or treatment of infection by the human immunodeficiency virus (HIV), and in the treatment of consequent pathological conditions such as the acquired immunodeficiency syndrome (AIDS) in mammals capable of being infected with HIV virus.
    Type: Grant
    Filed: September 9, 1996
    Date of Patent: October 19, 1999
    Assignee: Merrell Pharmaceuticals Inc.
    Inventors: Robert A. Farr, Brent L. Podlogar