Patents by Inventor Brent M. Dorr

Brent M. Dorr has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230193227
    Abstract: The present disclosure provides engineered carboxyesterase enzymes that have the ability to catalyze amide bond formation. Also provided are polynucleotides encoding the carboxyesterase enzymes, host cells capable of expressing the engineered carboxyesterase enzymes, and methods of using the engineered carboxyesterase enzymes to make commercially valuable amides. Also provided are amides that are made using the engineered carboxyesterase enzymes.
    Type: Application
    Filed: October 13, 2022
    Publication date: June 22, 2023
    Inventors: Kristin K. Brown, Brent M. Dorr, Douglas E. Fuerst, Katherine Joyce Honicker, Lydia Sanchez Jordan, James Patrick Morrison, Nikolay V. Plotnikov, Markus Schober, Rama Voladri
  • Patent number: 11535833
    Abstract: The present disclosure provides engineered carboxyesterase enzymes that have the ability to catalyze amide bond formation. Also provided are polynucleotides encoding the carboxyesterase enzymes, host cells capable of expressing the engineered carboxyesterase enzymes, and methods of using the engineered carboxyesterase enzymes to make commercially valuable amides. Also provided are amides that are made using the engineered carboxyesterase enzymes.
    Type: Grant
    Filed: December 13, 2018
    Date of Patent: December 27, 2022
    Assignee: GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED
    Inventors: Kristin K. Brown, Brent M. Dorr, Douglas E. Fuerst, Katherine Joyce Honicker, Lydia Sanchez Jordan, James Patrick Morrison, Nikolay V. Plotnikov, Markus Schober, Rama Voladri
  • Publication number: 20210115417
    Abstract: The present disclosure provides engineered carboxyesterase enzymes that have the ability to catalyze amide bond formation. Also provided are polynucleotides encoding the carboxyesterase enzymes, host cells capable of expressing the engineered carboxyesterase enzymes, and methods of using the engineered carboxyesterase enzymes to make commercially valuable amides. Also provided are amides that are made using the engineered carboxyesterase enzymes.
    Type: Application
    Filed: December 13, 2018
    Publication date: April 22, 2021
    Inventors: Kristin K. BROWN, Brent M. DORR, Douglas E. FUERST, Katherina Joyce HONICKER, Lydia Sanchez JORDAN, James Patrick MORRISON, Nikolay V. PLOTNIKOV, Markus SCHOBER, Rama VOLADRI
  • Patent number: 10202593
    Abstract: Evolved sortases exhibiting enhanced reaction kinetics and/or altered substrate preferences are provided herein, for example evolved sortases that bind recognitions motifs comprising a LAXT or LPXS sequence. Also provided are methods (e.g., orthogonal transpeptidation and diagnostics methods) for using such sortases. Kits comprising materials, reagents, and cells for carrying out the methods described herein are also provided.
    Type: Grant
    Filed: September 19, 2014
    Date of Patent: February 12, 2019
    Assignee: President and Fellows of Harvard College
    Inventors: David R. Liu, Brent M. Dorr
  • Publication number: 20160244747
    Abstract: Strategies, systems, methods, reagents, and kits for the directed evolution of bond-forming enzymes are provided herein. Evolution products, for example, evolved sortases exhibiting enhanced reaction kinetics and/or altered substrate preferences are also provided herein, as are methods for using such evolved bond-forming enzymes. Kits comprising materials, reagents, and cells for carrying out the directed evolution methods described herein are also provided.
    Type: Application
    Filed: February 22, 2016
    Publication date: August 25, 2016
    Applicant: President and Fellows of Harvard College
    Inventors: David R. Liu, Irwin Chen, Brent M. Dorr
  • Publication number: 20160208233
    Abstract: Evolved sortases exhibiting enhanced reaction kinetics and/or altered substrate preferences are provided herein, for example evolved sortases that bind recognitions motifs comprising a LAXT or LPXS sequence. Also provided are methods (e.g., orthogonal transpeptidation and diagnostics methods) for using such sortases. Kits comprising materials, reagents, and cells for carrying out the methods described herein are also provided.
    Type: Application
    Filed: September 19, 2014
    Publication date: July 21, 2016
    Applicant: President and Fellows of Harvard College
    Inventors: David R. Liu, Brent M. Dorr
  • Patent number: 9267127
    Abstract: Strategies, systems, methods, reagents, and kits for the directed evolution of bond-forming enzymes are provided herein. Evolution products, for example, evolved sortases exhibiting enhanced reaction kinetics and/or altered substrate preferences are also provided herein, as are methods for using such evolved bond-forming enzymes. Kits comprising materials, reagents, and cells for carrying out the directed evolution methods described herein are also provided.
    Type: Grant
    Filed: June 20, 2013
    Date of Patent: February 23, 2016
    Assignee: President and Fellows of Harvard College
    Inventors: David R. Liu, Irwin Chen, Brent M. Dorr
  • Publication number: 20150284477
    Abstract: Compositions, reagents, kits, and methods for the reversible, covalent conjugation of functional molecules to engineered surfaces, e.g., surfaces of biomedical devices or used in analytical assays or industrial catalysis, are provided. The compositions, reagents, kits, and methods provided herein allow for the attachment, release, and replacement of functional molecules to and from engineered surfaces in vitro, in situ, and in vivo. Implantable vascular grafts, stents, catheters, and other medical devices with immobilized thrombomodulin-coated surfaces are provided. These molecules can be released from the device surface and replaced with fresh thrombomodulin via systemic administration of the respective reactants and without the need to remove the device.
    Type: Application
    Filed: October 30, 2013
    Publication date: October 8, 2015
    Inventors: Elliot Chaikof, Zheng Qu, Carolyn Haller, David R. Liu, Brent M. Dorr
  • Publication number: 20140057317
    Abstract: Strategies, systems, methods, reagents, and kits for the directed evolution of bond-forming enzymes are provided herein. Evolution products, for example, evolved sortases exhibiting enhanced reaction kinetics and/or altered substrate preferences are also provided herein, as are methods for using such evolved bond-forming enzymes. Kits comprising materials, reagents, and cells for carrying out the directed evolution methods described herein are also provided.
    Type: Application
    Filed: June 20, 2013
    Publication date: February 27, 2014
    Applicant: President and Fellows of Harvard College
    Inventors: David R. Liu, Irwin Chen, Brent M. Dorr