Abstract: The present invention relates to methods for detecting sulfenylation within thiol groups in proteins, metabolites, or materials. Protein sulfenylation (Cys-SOH) describes the reversible post-translational modification of protein thiols by hydrogen peroxide, and plays a central role in oxidative signaling (see, e.g., Paulsen, C. E. & Carroll, K. S. 2013 Chemical Reviews 113, 4633-679). Growth factor stimulation activates NADPH oxidase enzymes, releasing a local burst of hydrogen peroxide, which transiently oxidizes the nuclcophilic cysteine of protein phosphatases and other proximal redox active thiols (see, e.g., Paulsen, C. E. et al., 2012 Nature Chemical Biology 8, 57-64). In addition to masking functional cysteine's, sulfenylation is also a critical intermediate towards irreversible cysteine oxidation.

Abstract: The present invention relates to methods for detecting protein S-sulfinylation and S-sulfinylation within thiol groups in proteins, metabolites, or materials.

Abstract: The present invention relates to methods for detecting protein S-sulfinylation and S-sulfinylation within thiol groups in proteins, metabolites, or materials.

Abstract: The present invention relates to methods for detecting sulfenylation within thiol groups in proteins, metabolites, or materials. Protein sulfenylation (Cys-SOH) describes the reversible post-translational modification of protein thiols by hydrogen peroxide, and plays a central role in oxidative signaling (see, e.g., Paulsen, C. E. & Carroll, K. S. 2013 Chemical Reviews 113, 4633-679). Growth factor stimulation activates NADPH oxidase enzymes, releasing a local burst of hydrogen peroxide, which transiently oxidizes the nuclcophilic cysteine of protein phosphatases and other proximal redox active thiols (see, e.g., Paulsen, C. E. et al., 2012 Nature Chemical Biology 8, 57-64). In addition to masking functional cysteine's, sulfenylation is also a aitical intermediate towards irreversible cysteine oxidation.

Abstract: The present invention relates to methods for detecting protein S-sulfinylation and S-sulfinylation within thiol groups in proteins, metabolites, or materials.

Abstract: Eyewear (10) comprises a frame (12) for housing a pair of eye lenses (14.1), (14.2) therein. The frame (12) has a bridge portion (16) for resting on a user's nose and a pair of temple members (18.1), (18.2) for locating the frame (12) in position on the head of a user. The temple members (18.1), (18.2), respectively, are pivotally connected by means of a pair of pivotal connections (19.1), (19.2) which are spaced from each other and located asymmetrically with respect to the bridge portion (16). In another embodiment (70) the frame (12) has a bridge portion (16) with opposing sides for resting on a user's nose, the opposing sides being asymmetrical with respect to each other. In a further embodiment the frame (12) has a bridge portion (16) with opposing sides and a nose pad (72), (74) on each of the opposing sides for resting on a user's nose, the nose pads (72), (74) being located at different positions on the respective sides of the bridge portion (16).

Abstract: Eyewear 10 comprises a frame 12 for housing a pair of lenses 14 therein. The frame 12 has a bridge portion 16 for bridging a user's nose and a pair of temple members 18 for locating the frame 12 in position on the head of a user. The frame 12 has a nose pad 20 in the form of a projection extending downwardly from the bridge portion 16 for resting by gravity on the frontal part of the bridge of a user's nose at the origin of the nose. According to another embodiment, a nose pad 30 which is detachable from the frame 12 is provided. The frame 12 and the nose pad 30 are provided with mutually engaging formations 32, 34 for detachably attaching the nose pad 30 to the frame 12.

Abstract: In one embodiment, eyewear, such as sunglasses (10), comprises a frame (12) for housing a pair of lenses (14.1) and (14.2) therein. The frame (12) has a bridge portion (16) for resting on a user's nose and a pair of temple members (18.1) and (18.2) for locating the frame (12) in position on the head of a user. The frame includes lens retaining portions (20.1) and (20.2) for housing the lenses (14.1) and (14.2). Each lens retaining portion (20.1), (20.2) comprises a pair of spaced frame portions (22.1), (22.2) and (24.1), (24.2) for receiving the respective lens (14.1), (14.2) therebetween. The lens retaining portions (20.1), (20.2) extend from the bridge portion (16) in opposite directions away from the bridge portion (16). One lens retaining portion (20.1) is larger than the other lens retaining portion (20.2) for extending at least partially around the side of a user's face. In a further embodiment the frame (12) also includes ventilation means, such as a ventilation opening (26) between the one lens (14.