Patents by Inventor Brent W. McCleland

Brent W. McCleland has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Biaryl pyrazoles as NRF2 regulators
    Patent number: 10364256
    Abstract: The present invention relates to biaryl pyrazole compounds of Formula (I) methods of making them, pharmaceutical compositions containing them and their use as NRF2 regulators.
    Type: Grant
    Filed: October 6, 2016
    Date of Patent: July 30, 2019
    Assignees: GlaxoSmithKline Intellectual Property Development Limited, Astex Therapeutics Limited
    Inventors: James Callahan, Jeffrey K. Kerns, Peng Li, Tindy Li, Brent W. McCleland, Hong Nie, Joseph E. Pero, Thomas Glanmor Davies, Maria Grazia Carr, Charlotte Mary Griffiths-Jones, Thomas Daniel Heightman, David Norton, Marinus Leendert Verdonk, Alison Jo-Anne Woolford, Hendrika Maria Gerarda Willems
  • Arylcyclohexyl pyrazoles as NRF2 regulators
    Patent number: 10351530
    Abstract: The present invention relates to arylcyclohexyl pyrazole compounds of Formula (I) methods of making them, pharmaceutical compositions containing them and their use as NRF2 regulators.
    Type: Grant
    Filed: October 6, 2016
    Date of Patent: July 16, 2019
    Assignees: GlaxoSmithKline Intellectual Property Development Limited, Astex Therapeutics Limited
    Inventors: James Callahan, Jeffrey K. Kerns, Tindy Li, Brent W. McCleland, Hong Nie, Joseph E. Pero, Thomas Glanmor Davies, Charlotte Mary Griffiths-Jones, Thomas Daniel Heightman, Steven Howard, David Norton, Marinus Leendert Verdonk, Alison Jo-Anne Woolford
  • ARYLCYCLOHEXYL PYRAZOLES AS NRF2 REGULATORS
    Publication number: 20180282283
    Abstract: The present invention relates to arylcyclohexyl pyrazole compounds of Formula (I) methods of making them, pharmaceutical compositions containing them and their use as NRF2 regulators.
    Type: Application
    Filed: October 6, 2016
    Publication date: October 4, 2018
    Inventors: James CALLAHAN, Jeffrey K. KERNS, Tindy LI, Brent W. McCLELAND, Hong NIE, Joseph E. PERO, Thomas Glanmor DAVIES, Charlotte Mary GRIFFITHS-JONES, Thomas Daniel HEIGHTMAN, Steven HOWARD, David NORTON, Marinus Leendert VERDONK, Alison Jo-Anne WOOLFORD
  • BIARYL PYRAZOLES AS NRF2 REGULATORS
    Publication number: 20180282349
    Abstract: The present invention relates to biaryl pyrazole compounds of Formula (I) methods of making them, pharmaceutical compositions containing them and their use as NRF2 regulators.
    Type: Application
    Filed: October 6, 2016
    Publication date: October 4, 2018
    Inventors: James CALLAHAN, Jeffrey K. KERNS, Peng LI, Tindy LI, Brent W. McCLELAND, Hong NIE, Joseph E. PERO, Thomas Glanmor DAVIES, Maria GRAZIA CARR, Charlotte Mary GRIFFITHS-JONES, Thomas Daniel HEIGHTMAN, David NORTON, Marinus Leedert VERDONK, Alison Jo-Anne WOOLFORD, Hendrika Maria Gerarda WILLEMS
  • MUSCARINIC ACETYLCHOLINE RECEPTOR ANTAGONISTS
    Publication number: 20160002220
    Abstract: Methods of using Muscarinic Acetylcholine Receptor Antagonists are provided.
    Type: Application
    Filed: September 10, 2015
    Publication date: January 7, 2016
    Inventors: Dramane Ibrahim Laine, Michael R. Palovich, Brent W. McCleland, Christopher E. Neipp, Sonia M. Thomas
  • Muscarinic acetylcholine receptor antagonists
    Patent number: 9144571
    Abstract: Methods of using Muscarinic Acetylcholine Receptor Antagonists are provided.
    Type: Grant
    Filed: May 8, 2015
    Date of Patent: September 29, 2015
    Assignee: Glaxo Group Limited
    Inventors: Dramane Ibrahim Laine, Michael R. Palovich, Brent W. McCleland, Christopher E. Neipp, Sonia M. Thomas
  • MUSCARINIC ACETYLCHOLINE RECEPTOR ANTAGONISTS
    Publication number: 20150238470
    Abstract: Methods of using Muscarinic Acetylcholine Receptor Antagonists are provided.
    Type: Application
    Filed: May 8, 2015
    Publication date: August 27, 2015
    Inventors: Dramane Ibrahim Laine, Michael R. Palovich, Brent W. McCleland, Christopher E. Neipp, Sonia M. Thomas
  • Muscarinic acetylcholine receptor antagonists
    Patent number: 9045469
    Abstract: Muscarinic Acetylcholine Receptor Antagonists and methods of using them are provided.
    Type: Grant
    Filed: September 4, 2014
    Date of Patent: June 2, 2015
    Assignee: Glaxo Group Limited
    Inventors: Dramane Ibrahim Laine, Michael R. Palovich, Brent W. McCleland, Christopher E. Neipp, Sonia M. Thomas
  • MUSCARINIC ACETYLCHOLINE RECEPTOR ANTAGONISTS
    Publication number: 20140371264
    Abstract: Muscarinic Acetylcholine Receptor Antagonists and methods of using them are provided.
    Type: Application
    Filed: September 4, 2014
    Publication date: December 18, 2014
    Inventors: Dramane Ibrahim Laine, Michael R. Palovich, Brent W. McCleland, Christopher E. Neipp, Sonia M. Thomas
  • Muscarinic acetylcholine receptor antagonists
    Patent number: 8853404
    Abstract: Muscarinic Acetylcholine Receptor Antagonists and methods of using them are provided.
    Type: Grant
    Filed: October 14, 2013
    Date of Patent: October 7, 2014
    Assignee: Glaxo Group Limited
    Inventors: Dramane Ibrahim Laine, Michael R. Palovich, Brent W. McCleland, Christopher E. Neipp, Sonia M. Thomas
  • MUSCARINIC ACETYLCHOLINE RECEPTOR ANTAGONISTS
    Publication number: 20140080863
    Abstract: Muscarinic Acetylcholine Receptor Antagonists and methods of using them are provided.
    Type: Application
    Filed: October 14, 2013
    Publication date: March 20, 2014
    Applicant: Glaxo Group Limited
    Inventors: Dramane Ibrahim LAINE, Michael R. Palovich, Brent W. McCleland, Christopher E. Neipp, Sonia M. Thomas
  • Muscarinic acetylcholine receptor antagonists
    Patent number: 8575347
    Abstract: Muscarinic Acetylcholine Receptor Antagonists and methods of using them are provided.
    Type: Grant
    Filed: September 26, 2012
    Date of Patent: November 5, 2013
    Assignee: Glaxo Group Limited
    Inventors: Dramane Ibrahim Laine, Michael R. Palovich, Brent W. McCleland, Christopher E. Neipp, Sonia M. Thomas
  • MUSCARINIC ACETYLCHOLINE RECEPTOR ANTAGONISTS
    Publication number: 20130030015
    Abstract: Muscarinic Acetylcholine Receptor Antagonists and methods of using them are provided.
    Type: Application
    Filed: September 26, 2012
    Publication date: January 31, 2013
    Applicant: Glaxo Group Limited
    Inventors: Dramane I. LAINE, Michael R. Palovich, Brent W. McCleland, Christopher E. Neipp, Sonia M. Thomas
  • Muscarinic acetylcholine receptor antagonists
    Patent number: 8309572
    Abstract: Muscarinic Acetylcholine Receptor Antagonists and methods of using them are provided.
    Type: Grant
    Filed: February 22, 2012
    Date of Patent: November 13, 2012
    Assignee: Glaxo Group Limited
    Inventors: Dramane I. Laine, Michael R. Palovich, Brent W. McCleland, Christopher E. Neipp, Sonia M. Thomas
  • MUSCARINIC ACETYLCHOLINE RECEPTOR ANTAGONISTS
    Publication number: 20120157491
    Abstract: Muscarinic Acetylcholine Receptor Antagonists and methods of using them are provided.
    Type: Application
    Filed: February 22, 2012
    Publication date: June 21, 2012
    Applicant: Glaxo Group Limited
    Inventors: Dramane I. Laine, Michael R. Palovich, Brent W. McCleland, Christopher E. Neipp, Sonia M. Thomas
  • Muscarinic acetylcholine receptor antagonists
    Patent number: 8183257
    Abstract: Muscarinic Acetylcholine Receptor Antagonists and methods of using them are provided.
    Type: Grant
    Filed: January 14, 2009
    Date of Patent: May 22, 2012
    Assignee: Glaxo Group Limited
    Inventors: Dramane I. Laine, Michael R. Palovich, Brent W. McCleland, Christopher E. Neipp, Sonia M. Thomas
  • Mmuscarinic acetylcholine receptor antagonists
    Patent number: 7932247
    Abstract: Muscarinic Acetylcholine receptor antagonists and methods of using them are provided.
    Type: Grant
    Filed: November 15, 2005
    Date of Patent: April 26, 2011
    Assignee: Glaxo Group Limited
    Inventors: Brian W. Budzik, Anthony W. J. Cooper, Jian Jin, Dramane I. Laine, Brent W. McCleland, Michael R. Palovich, Ralph A. Rivero, Yonghui Wang, Haibo Xie, Chongjie Zhu
  • Muscarinic acetylcholine receptor antagonists containing an azoniabiocyclo[2.2.1] heptane ring system
    Patent number: 7767691
    Abstract: Muscarinic Acetylcholine receptor antagonists and methods of using them are provided.
    Type: Grant
    Filed: August 17, 2006
    Date of Patent: August 3, 2010
    Assignee: Glaxo Group Limited
    Inventors: Dramane I. Laine, Michael R. Palovich, Brent W. McCleland
  • Cathepsin C Inhibitors
    Publication number: 20090264498
    Abstract: This invention relates to compounds of formula (I) which are useful for treating chronic obstructive pulmonary disease, and the like.
    Type: Application
    Filed: April 16, 2009
    Publication date: October 22, 2009
    Inventors: Dramane Ibrahim Laine, Guoliang Lin, Brent W. McCleland, Michael R. Palovich
  • Cathepsin C Inhibitors
    Publication number: 20090264499
    Abstract: A compound of formula (IA) or (IB) and their use in treating inflammatory diseases such as COPD.
    Type: Application
    Filed: April 16, 2009
    Publication date: October 22, 2009
    Inventors: Jianghe DENG, Dramane Ibrahim Laine, Brent W. McCleland, Michael R. Palovich, Emilie Veronique Petitjean