Abstract: An apparatus, method, and system are disclosed for improving uniformity of RF magnetic field in an MRI system, and thereby improving both signal-to-noise ratio and uniformity of imaging sensitivity across a sampling volume, to provide more uniform MRI images. A passive LC resonator develops induced EMF and induced currents in a primary RF magnetic field; the secondary magnetic field produced thereby can counteract magnetic field amplitude gradients to produce a more homogeneous RF magnetic field. In systems with separate transmit and receive coils, a shunt detuning circuit is pulsed ON to prevent interference during the transmit period. In a dual-frequency MRI machine (e.g. 19F and 1H), the RF magnetic field at the lower operating frequency can be homogenized by tuning the resonance of the passive resonator between the two operating frequencies. Another resonator can improve RF field uniformity at the higher operating frequency. Variants and experimental results are disclosed.

Abstract: An apparatus, method, and system are disclosed for improving uniformity of RF magnetic field in an MRI system, and thereby improving both signal-to-noise ratio and uniformity of imaging sensitivity across a sampling volume, to provide more uniform MRI images. A passive LC resonator develops induced EMF and induced currents in a primary RF magnetic field; the secondary magnetic field produced thereby can counteract magnetic field amplitude gradients to produce a more homogeneous RF magnetic field. In systems with separate transmit and receive coils, a shunt detuning circuit is pulsed ON to prevent interference during the transmit period. In a dual-frequency MRI machine (e.g. 19F and 1H), the RF magnetic field at the lower operating frequency can be homogenized by tuning the resonance of the passive resonator between the two operating frequencies. Another resonator can improve RF field uniformity at the higher operating frequency. Variants and experimental results are disclosed.

Abstract: An apparatus, method, and system are disclosed for improving uniformity of RF magnetic field in an MRI system, and thereby improving both signal-to-noise ratio and uniformity of imaging sensitivity across a sampling volume, to provide more uniform MRI images. A passive LC resonator develops induced EMF and induced currents in a primary RF magnetic field; the secondary magnetic field produced thereby can counteract magnetic field amplitude gradients to produce a more homogeneous RF magnetic field. In systems with separate transmit and receive coils, a shunt detuning circuit is pulsed ON to prevent interference during the transmit period. In a dual-frequency MRI machine (e.g. 19F and 1H), the RF magnetic field at the lower operating frequency can be homogenized by tuning the resonance of the passive resonator between the two operating frequencies. Another resonator can improve RF field uniformity at the higher operating frequency. Variants and experimental results are disclosed.

Abstract: An apparatus, method, and system are disclosed for improving uniformity of RF magnetic field in an MRI system, and thereby improving both signal-to-noise ratio and uniformity of imaging sensitivity across a sampling volume, to provide more uniform MRI images. A passive LC resonator develops induced EMF and induced currents in a primary RF magnetic field; the secondary magnetic field produced thereby can counteract magnetic field amplitude gradients to produce a more homogeneous RF magnetic field. In systems with separate transmit and receive coils, a shunt detuning circuit is pulsed ON to prevent interference during the transmit period. In a dual-frequency MRI machine (e.g. 19F and 1H), the RF magnetic field at the lower operating frequency can be homogenized by tuning the resonance of the passive resonator between the two operating frequencies. Another resonator can improve RF field uniformity at the higher operating frequency. Variants and experimental results are disclosed.

Abstract: The present invention relates to nucleotide sequences of clk-2 genes, particularly human clk-2, and amino acid sequences of their encoded proteins, as well as derivatives and analogs thereof. The present invention also relates to methods and compositions designed for the treatment, management, or prevention of disorders associated with abnormal expression and/or activity of clk-2 nucleic acids and/or proteins. In one embodiment, the invention encompasses a method of treating or preventing a disorder associated with decreased apoptosis (e.g., cancer, autoimmune disorders) or decreased telomere length (e.g., rapid aging or advanced age) by administering to a subject in need thereof an effective amount of an agent that promotes clk-2 activity. In another embodiment, invention encompasses a method of treating or preventing a disorder associated with increased apoptosis (e.g., neurodegenerative disorders) and increased telomere length (e.g.

Abstract: The present invention relates to a clk-2 gene which has a function at the level of cellular physiology involved in developmental rate, telomere length and longevity, wherein clk-2 mutations cause a longer life, an altered cellular metabolism and an altered telomere length relative to the wild type, wherein clk-2 overexpression leads to telomere shortening. The present invention also relates to clk-2 co-expressed gene which comprises a cex-7 gene having the nucleotide sequence set forth in FIG. 33 which codes for a CEX-7 protein having the amino acid sequence set forth in FIG. 34 wherein said gene is located in the clk-2 operon and said cex-7 gene is transcriptionally co-expressed with clk-2 gene present in said operon.