Patents by Inventor Brenton R. Ware

Brenton R. Ware has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Stem cell-derived hepatocytes in co-culture and uses thereof
    Patent number: 10717966
    Abstract: The present disclosure provides co-cultures of human pluripotent stem cell derived hepatocytes and at least one non-parenchymal cell population in vitro, methods of preparing the co-cultures and methods of using the co-cultures for high throughput screening and evaluation of drug candidates. The stem cell derived hepatocyte co-culture system provides an in vitro model in which cell viability and relatively mature hepatocyte phenotype of stem cell derived hepatocytes are maintained for extended periods relative to conventional monoculture.
    Type: Grant
    Filed: October 11, 2018
    Date of Patent: July 21, 2020
    Assignee: COLORADO STATE UNIVERSITY RESEARCH FOUNDATION
    Inventors: Salman R. Khetani, Dustin R. Berger, Brenton R. Ware
  • Stem cell-derived hepatocytes in co-culture and uses thereof
    Patent number: 10266806
    Abstract: The present disclosure provides co-cultures of human pluripotent stem cell derived hepatocytes and at least one non-parenchymal cell population in vitro, methods of preparing the co-cultures and methods of using the co-cultures for high throughput screening and evaluation of drug candidates. The stem cell derived hepatocyte co-culture system provides an in vitro model in which cell viability and relatively mature hepatocyte phenotype of stem cell derived hepatocytes are maintained for extended periods relative to conventional monoculture.
    Type: Grant
    Filed: January 14, 2015
    Date of Patent: April 23, 2019
    Assignee: Colorado State University Research Foundation
    Inventors: Salman R. Khetani, Dustin R. Berger, Brenton R. Ware
  • STEM CELL-DERIVED HEPATOCYTES IN CO-CULTURE AND USES THEREOF
    Publication number: 20190048315
    Abstract: The present disclosure provides co-cultures of human pluripotent stem cell derived hepatocytes and at least one non-parenchymal cell population in vitro, methods of preparing the co-cultures and methods of using the co-cultures for high throughput screening and evaluation of drug candidates. The stem cell derived hepatocyte co-culture system provides an in vitro model in which cell viability and relatively mature hepatocyte phenotype of stem cell derived hepatocytes are maintained for extended periods relative to conventional monoculture.
    Type: Application
    Filed: October 11, 2018
    Publication date: February 14, 2019
    Applicant: Colorado State University Research Foundation
    Inventors: Salman R. Khetani, Dustin R. Berger, Brenton R. Ware
  • ENGINEERED PLATFORMS TO STABILIZE BOTH HEPATOCYTES AND ENDOTHELIAL CELLS IN VITRO
    Publication number: 20180223253
    Abstract: The disclosure relates to in vitro cultures of human hepatocytes, and in particular co-cultures systems including human hepatocytes, non-parenchymal cells, and human endothelial cells, and the use of the co-cultures in developing and screening drugs.
    Type: Application
    Filed: August 5, 2016
    Publication date: August 9, 2018
    Applicant: Colorado State University Research Foundation
    Inventors: Salman R. Khetani, Mitchell J. Durham, Brenton R. Ware
  • STEM CELL-DERIVED HEPATOCYTES IN CO-CULTURE AND USES THEREOF
    Publication number: 20150240203
    Abstract: The present disclosure provides co-cultures of human pluripotent stem cell derived hepatocytes and at least one non-parenchymal cell population in vitro, methods of preparing the co-cultures and methods of using the co-cultures for high throughput screening and evaluation of drug candidates. The stem cell derived hepatocyte co-culture system provides an in vitro model in which cell viability and relatively mature hepatocyte phenotype of stem cell derived hepatocytes are maintained for extended periods relative to conventional monoculture.
    Type: Application
    Filed: January 14, 2015
    Publication date: August 27, 2015
    Inventors: Salman R. Khetani, Dustin R. Berger, Brenton R. Ware