Patents by Inventor Brenton T Flatt

Brenton T Flatt has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pyrrole derivatives as pharmaceutical agents
    Patent number: 8026237
    Abstract: Compounds, compositions and methods for modulating the activity of receptors are provided. In particular compounds and compositions are provided for modulating the activity of receptors and for the treatment, prevention, or amelioration of one or more symptoms of disease or disorder directly or indirectly related to the activity of the receptors.
    Type: Grant
    Filed: July 30, 2005
    Date of Patent: September 27, 2011
    Assignee: Exelixis, Inc.
    Inventors: Lynne Canne Bannen, Jeff Chen, Lisa Esther Dalrymple, Brenton T Flatt, Timothy Patrick Forsyth, Xiao-Hui Gu, Morrison B Mac, Larry W Mann, Grace Mann, Richard Martin, Raju Mohan, Brett Murphy, Michael Charles Nyman, William C Stevens, Tie-Lin Wang, Yong Wang, Jason H Wu
  • Heterocyclic Carboxamide Compounds as Steroid Nuclear Receptors Ligands
    Publication number: 20110144128
    Abstract: Heterocyclic carboxamide compounds are described herein as being useful in modulating the activity of steroid nuclear receptors. Pharmaceutical compositions containing the compounds, methods of using the compounds and processes for making the compounds are also described.
    Type: Application
    Filed: January 6, 2006
    Publication date: June 16, 2011
    Applicant: EXELIXIS, INC.
    Inventors: Brenton T. Flatt, Xiao-Hui Gu, Richard Martin, Raju Mohan, Brett Murphy, Michael C. Nyman, William C. Stevens, JR., Tie-Lin Wang
  • Bridged ring structures as pharmaceutical agents
    Patent number: 7863298
    Abstract: The present invention is directed to 1?,25-dihydroxyvitamin D3 mimics which modulate the vitamin D receptor (VDR). The invention is further directed to pharmaceutical compositions and methods for the treatment, prevention or amelioration of one or more symptoms of disease or disorder related to the activity of the vitamin D receptor using an effective amount of a compound of formula (I).
    Type: Grant
    Filed: October 13, 2004
    Date of Patent: January 4, 2011
    Assignee: Exelixis, Inc.
    Inventors: Brenton T. Flatt, Richard Martin, Raju Mohan, Brett Murphy
  • MODULATORS OF LXR
    Publication number: 20100331295
    Abstract: Compounds of the invention, such as compounds of Formulae Ia, Ib, Ic, or Id and pharmaceutically acceptable salts, isomers, and prodrugs thereof, which are useful as modulators of the activity of liver X receptors, where R1, R2, R21, R3, and G are defined herein. Pharmaceutical compositions containing the compounds and methods of using the compounds are also disclosed.
    Type: Application
    Filed: June 26, 2006
    Publication date: December 30, 2010
    Applicant: EXELIXIS, INC.
    Inventors: Brett B Busch, Brenton T. Flatt, Xiao Hui Gu, Shao Po Lu, Richard Martin, Raju Mohan, Michael Charles Nyman, Edwin Schweiger, William C. Stevens, JR., Tie Lin Wang, Yinong Xie
  • Azepinoindole Derivatives As Pharmaceutical Agents
    Publication number: 20100173824
    Abstract: Compounds, compositions and methods for modulating the activity of receptors are provided. In particular, compounds and compositions are provided for modulating the activity of receptors and for the treatment, prevention, or amelioration of one or more symptoms of disease or disorder directly or indirectly related to the activity of the receptors.
    Type: Application
    Filed: August 4, 2009
    Publication date: July 8, 2010
    Applicant: EXELIXIS, INC.
    Inventors: Brett Busch, Brenton T. Flatt, Xiao-Hui Gu, Richard Martin, Raju Mohan, Tie-Lin Wang, Jason H. Wu
  • IMIDAZOLE BASED LXR MODULATORS
    Publication number: 20100075964
    Abstract: Compounds of the invention, such as compounds of Formulae IIa, IIb, IIc or IId, and pharmaceutically acceptable salts, isomers, and prodrugs thereof, are useful as modulators of the activity of liver X receptors, where R1, R2, R21, R3 and G are defined herein. Pharmaceutical compositions containing the compounds and methods of using the compounds are also disclosed.
    Type: Application
    Filed: June 26, 2006
    Publication date: March 25, 2010
    Applicant: EXELIXIS, INC.
    Inventors: Brett B. Busch, Brenton T. Flatt, Xiao-Hui Gu, Shao-Po Lu, Richard Martin, Raju Mohan, Michael Charles Nyman, Edwin Schweiger, William C. Stevens, Jr., Tie-Lin Wang, Yinong Xie
  • Azepinoindole and Pyridoindole Derivatives as Pharmaceutical Agents
    Publication number: 20090326218
    Abstract: Compounds, compositions and methods for modulating the activity of receptors are provided. In particular compounds and compositions are provided for modulating the activity of receptors and for the treatment, prevention, or amelioration of one or more symptoms of disease or disorder directly or indirectly related to the activity of the receptors.
    Type: Application
    Filed: January 29, 2009
    Publication date: December 31, 2009
    Applicant: EXELIXIS, INC.
    Inventors: Richard Martin, Tie-Lin Wang, Brenton T. Flatt, Xiao-Hui Gu, Ronald Griffith
  • 11 Beta-HSD1 Modulators
    Publication number: 20090247515
    Abstract: A compound according to Formula A: or a pharmaceutically acceptable salt thereof, wherein R11, G1 and G2 are as defined in the specification, pharmaceutical compositions thereof, and methods of use thereof.
    Type: Application
    Filed: March 13, 2009
    Publication date: October 1, 2009
    Applicant: Exelixis, Inc.
    Inventors: Richard Martin, Brenton T. Flatt, Jackline Eve Dalgard, Venkataiah Bollu, Ping Huang, Raju Mohan, Edwin Schweiger, Tie-Lin Wang
  • Azepinoindole derivatives as pharmaceutical agents
    Patent number: 7595311
    Abstract: Compounds, compositions and methods for modulating the activity of receptors are provided. In particular, compounds and compositions are provided for modulating the activity of receptors and for the treatment, prevention, or amelioration of one or more symptoms of disease or disorder directly or indirectly related to the activity of the receptors.
    Type: Grant
    Filed: December 2, 2003
    Date of Patent: September 29, 2009
    Assignee: Exelixis, Inc.
    Inventors: Brett Busch, Brenton T Flatt, Xiao-Hui Gu, Richard Martin, Raju Mohan, Tie-Lin Wang, Jason H Wu
  • Azepinoindole Derivatives As Pharmaceutical Agents
    Publication number: 20090203577
    Abstract: The present invention relates to compounds of formula I, which exhibit affinity for the farnesoid X receptor.
    Type: Application
    Filed: December 12, 2006
    Publication date: August 13, 2009
    Applicant: EXELIXIS, INC.
    Inventors: Tae-Gon Baik, Chris A. Buhr, Brett B. Busch, Diva Sze-Ming Chan, Brenton T. Flatt, Xiao-Hui Gu, Vasu Jammalamadaka, Richard George Khoury, Katherine Lara, Sunghoon Ma, Richard Martin, Raju Mohan, John M. Nuss, Jason Jevious Parks, Jason H. Wu, Bryan K. S. Yeung, Wei Xu, Tie-Lin Wang, Longcheng Wang
  • Azepinoindole and pyridoindole derivatives as pharmaceutical agents
    Patent number: 7485634
    Abstract: Compounds, compositions and methods for modulating the activity of receptors are provided. In particular compounds and compositions are provided for modulating the activity of receptors and for the treatment, prevention, or amelioration of one or more symptoms of disease or disorder directly or indirectly related to the activity of the receptors.
    Type: Grant
    Filed: May 27, 2003
    Date of Patent: February 3, 2009
    Assignee: Exelixis, Inc.
    Inventors: Richard Martin, Tie-Lin Wang, Brenton T Flatt, Xiao-Hui Gu, Ronald Griffith
  • Pyrrole Derivatives As Pharmaceutical Agents
    Publication number: 20080234270
    Abstract: Compounds, compositions and methods for modulating the activity of receptors are provided. In particular compounds and compositions are provided for modulating the activity of receptors and for the treatment, prevention, or amelioration of one or more symptoms of disease or disorder directly or indirectly related to the activity of the receptors.
    Type: Application
    Filed: July 30, 2005
    Publication date: September 25, 2008
    Applicant: EXELIXIS, INC.
    Inventors: Lynne Canne Bannen, Jeff Chen, Lisa Esther Dalrymple, Brenton T. Flatt, Timothy Patrick Forsyth, Xiao-Hui Gu, Morrison B. Mac, Larry W. Mann, Grace Mann, Richard Martin, Raju Mohan, Brett Murphy, Michael Charles Nyman, William C. Stevens, Tie-Lin Wang, Yong Wang, Jason H. Wu
  • Quinazolinone Modulators Of Nuclear Receptors
    Publication number: 20080070864
    Abstract: Compounds, pharmaceutical compositions and methods for modulating the activity of nuclear receptors are provided. In particular, quinazolinones are provided for modulating the activity of farnesoid X receptor (FXR) and/or orphan nuclear receptors.
    Type: Application
    Filed: March 4, 2003
    Publication date: March 20, 2008
    Applicant: X-Ceptor Therapeutics, Inc.
    Inventors: Richard Martin, Jeffrey D. Kahl, Brenton T. Flatt, Ronald Griffith
  • Heterocyclic modulators of nuclear receptors
    Patent number: 7115640
    Abstract: Compounds, compositions and methods for modulating the activity of nuclear receptors are provided. In particular, heterocyclic compounds are provided for modulating the activity of farnesoid X receptor (FXR), liver X receptor (LXR) and/or orphan nuclear receptors. In certain embodiments, the compounds are thiazolidinone derivatives.
    Type: Grant
    Filed: November 18, 2003
    Date of Patent: October 3, 2006
    Assignee: X-Ceptor Therapeutics, Inc.
    Inventors: Richard Martin, Brenton T Flatt, Jeffrey D Kahl, Tie-Lin Wang
  • Azepinoindole and pyridoindole derivatives as pharmaceutical agents
    Publication number: 20040023947
    Abstract: Compounds, compositions and methods for modulating the activity of receptors are provided. In particular compounds and compositions are provided for modulating the activity of receptors and for the treatment, prevention, or amelioration of one or more symptoms of disease or disorder directly or indirectly related to the activity of the receptors.
    Type: Application
    Filed: May 27, 2003
    Publication date: February 5, 2004
    Applicant: X-Ceptor Therapeutics Inc.
    Inventors: Richard Martin, Tie-Lin Wang, Brenton T. Flatt, Xiao-Hui Gu, Ronald Griffith
  • 2-aminopyridine derivatives and combinatorial libraries thereof
    Patent number: 6458789
    Abstract: The present invention relates to novel 2-aminopyridine derivative compounds of the following formula: wherein R1 to R5 have the meanings provided herein. The invention further relates to combinatorial libraries containing two or more such compounds, as well as methods of preparing 2-aminopyridine derivative compounds.
    Type: Grant
    Filed: September 29, 1999
    Date of Patent: October 1, 2002
    Assignee: Lion Bioscience AG
    Inventors: Behrouz Forood, Brenton T. Flatt, Christophe Chassaing, Alan K. Katritzky