Abstract: The invention generally relates to an auxiliary guidewire for an intravascular procedure. The invention provides an auxiliary guidewire that slips over a primary guidewire and can provide a very fine extension beyond the end of the primary guidewire. The primary guidewire can be taken to its limit within the fine vasculature, and the auxiliary guidewire can then extend further into the fine vasculature. The primary guidewire can be taken to a bifurcation. The primary guidewire and the auxiliary guidewire can be sent down separate branches of the bifurcation. A physician can select which of the primary guidewire and the auxiliary guidewire are within the branch that needs to be treated by, for example, consulting an angiography display.

Abstract: The invention provides a guidewire with a centering mechanism. The mechanism lifts the guidewire from a vessel wall and biases it towards the center of the vessel. Since the guidewire can be selectively lifted away from the vessel wall, scraping the catheter against the wall can be avoided, the tip can be guided into the correct branch of a bifurcation, and an imaging device can be used to its full potential. In certain aspects, the invention provides a guidewire with an elongated shaft with a proximal portion and a distal portion comprising a distal tip. One or more centering mechanism can be provided on a guidewire.

Abstract: The invention generally relates to an auxiliary guidewire for an intravascular procedure. The invention provides an auxiliary guidewire that slips over a primary guidewire and can provide a very fine extension beyond the end of the primary guidewire. The primary guidewire can be taken to its limit within the fine vasculature, and the auxiliary guidewire can then extend further into the fine vasculature. The primary guidewire can be taken to a bifurcation. The primary guidewire and the auxiliary guidewire can be sent down separate branches of the bifurcation. A physician can select which of the primary guidewire and the auxiliary guidewire are within the branch that needs to be treated by, for example, consulting an angiography display.

Abstract: The invention generally relates to systems and methods for predicting impact of a catheter on curvature of a vessel. In certain aspects, the invention provides a system for predicting impact of a catheter on curvature of a vessel. The system includes a central processing unit (CPU) and storage coupled to the CPU for storing instructions. The stored instructions, when executed by the CPU, cause the CPU to accept as input data representative of stiffness of a catheter. The CPU is additionally caused to compare the data to a material parameters data set. The material parameters data set includes vessel displacement values for catheters of different stiffness. The CPU is additionally caused to predict impact of the catheter on a curvature of a vessel based on the comparison of the data to the material parameters data set, and to provide the prediction as an output.

Abstract: The invention provides a method of intravascular intervention that includes inserting a catheter comprising an extended body into a lumen within tissue of a patient, advancing the catheter to a treatment site, vibrating a proximal end of the catheter with a mechanical vibrator, and treating the treatment site while a distal end of the catheter is vibrating.

Abstract: The invention generally relates to systems and methods for determining coronary flow reserve (CFR). The invention provides systems and methods for determining coronary flow reserve using a flow reserve index obtained at rest and during hyperemia. One flow reserve index obtained under the two conditions can be used to compute coronary flow reserve. The difference between the resting value and the hyperemic value of the index correlates to a coronary flow reserve value.

Abstract: The invention generally relates to an auxiliary guidewire for an intravascular procedure. The invention provides an auxiliary guidewire that slips over a primary guidewire and can provide a very fine extension beyond the end of the primary guidewire. The primary guidewire can be taken to its limit within the fine vasculature, and the auxiliary guidewire can then extend further into the fine vasculature. The primary guidewire can be taken to a bifurcation. The primary guidewire and the auxiliary guidewire can be sent down separate branches of the bifurcation. A physician can select which of the primary guidewire and the auxiliary guidewire are within the branch that needs to be treated by, for example, consulting an angiography display.

Abstract: The invention generally relates to sensing guidewires with a centering element and methods of use thereof. In certain aspects, guidewires of the invention include a core member sized to fit within a vessel. A sensor is coupled to the core member. A centering element including a retracted and deployed configuration that is coupled to the core member such that upon deployment of the centering element, the sensor on the core member is located within a center of a lumen.

Abstract: The invention generally relates to imaging devices and methods of use thereof. Aspects of the invention provide an imaging device that includes a core wire and more than 32 optical fibers coupled to the core wire.

Abstract: The invention provides a guidewire with a centering mechanism. The mechanism lifts the guidewire from a vessel wall and biases it towards the center of the vessel. Since the guidewire can be selectively lifted away from the vessel wall, scraping the catheter against the wall can be avoided, the tip can be guided into the correct branch of a bifurcation, and an imaging device can be used to its full potential. In certain aspects, the invention provides a guidewire with an elongated shaft with a proximal portion and a distal portion comprising a distal tip. One or more centering mechanism can be provided on a guidewire.

Abstract: The invention generally relates to devices and methods that allow an operator to obtain real-time images of a luminal surface prior to, during, and after an intraluminal procedure, including while an intraluminal tool is engaged with the luminal surface. In one embodiment, an imaging system of the invention includes a guidewire comprising a first imaging element and a catheter comprising a second imaging element and a lumen that is configured to slidably receive at least a portion of the guidewire within. The first and second imaging elements are optical-to-acoustic transducers. The catheter is configured to move along a path of the guidewire to obtain real-time images within the lumen of a vessel and of the luminal surface.

Abstract: The invention generally relates to devices and methods that allow an operator to obtain real-time images of a luminal surface prior to, during, and after an intraluminal procedure, including while an intraluminal tool is engaged with the luminal surface. In one embodiment, an imaging system of the invention includes a first elongate member that includes at least one first imaging element and a second member that includes at least one second imaging element. The first imaging element is an optical-to-acoustic transducer, and the second imaging element is an optical-to-acoustic transducer. The second member also defines a lumen. The second member is configured to receive at least a portion of the first elongate member within the lumen and is configured to move along a path of the first elongate member to obtain real-time images within the lumen and of the luminal surface.

Abstract: The invention provides an intravascular catheter with an expandable member such as a balloon with an imaging device on a surface of the expandable member. The imaging device can use an optical fiber on a surface of the expandable member to image a treatment site. Since an image can be captured directly from the surface of the expandable member, an operator can examine the treatment site while positioning the expandable member. With the treatment site in view, the operator can deliver the treatment (e.g., inflate the balloon or deploy the stent) with confidence that it will be located properly.

Abstract: The invention generally relates to guidewires for intravascular procedures that include an electroactive polymer. An electroactive polymer can be at one or a number of locations on or within a guidewire. The polymer reacts to an applied electrical potential by changing a dimension (e.g., contracting or expanding). Electroactive polymers can be disposed along or within the guidewires in any pattern, such as wrapped helically within a surface, placed longitudinally parallel to an axis of the guidewire, dispose circumferentially around the guidewire, others, or a combination thereof. Depending on the designed geometry, a potential difference applied by an actuator will cause the guidewire to change a shape, a property, a surface characteristic, a dimension, or a combination thereof.

Abstract: The invention generally relates to devices and methods that allow an operator to obtain real-time images of a luminal surface prior to, during, and after an intraluminal procedure, including while a tool is engaged with the luminal surface. An imaging system of the invention may include a first elongate member that includes a first imaging element and a catheter that includes a second imaging element. The first imaging element is an optical-to-acoustic transducer, and the second imaging element is an optical-to-acoustic transducer. The catheter also defines a lumen and includes an implant delivery mechanism. The catheter is configured to receive at least a portion of the elongate member within the lumen and is configured to move along a path of the elongate member.

Abstract: The present invention generally relates to methods and devices for sensing the surface of a luminal wall. The invention can involve an elongated body configured to fit within the lumen of a vessel and at least one touch sensor located on the elongated body.

Abstract: The present invention generally relates to guidewire connectors. The invention can involve a housing that includes a channel. The invention can also involve at least one contact element configured to hold a guidewire inside the housing by pressing the guidewire against the channel.

Abstract: The invention generally relates to devices and methods that allow an operator to obtain real-time images of a luminal surface prior to, during, and after an intraluminal procedure, including while a tool is engaged with the luminal surface. An imaging system of the invention may include a first elongate member that includes a first imaging element and a catheter that includes a second imaging element. The first imaging element is an optical-to-acoustic transducer, and the second imaging element is an optical-to-acoustic transducer. The catheter also defines a lumen and includes an ablation element. The catheter is configured to receive at least a portion of the elongate member within the lumen and is configured to move along a path of the elongate member.

Abstract: The invention generally relates to devices and methods that allow an operator to obtain real-time images of a luminal surface prior to, during, and after an intraluminal procedure, including while a tool is engaged with the luminal surface. An imaging system of the invention may include a first elongate member that includes a first imaging element and a catheter that includes a second imaging element. The first imaging element is an optical-to-acoustic transducer, and the second imaging element is an optical-to-acoustic transducer. The catheter also defines a lumen and includes cutting element. The catheter is configured to receive at least a portion of the elongate member within the lumen and is configured to move along a path of the elongate member.