Abstract: Provided herein are methods and compositions for preparing nucleic acid templates wherein spatial-proximal and molecular contiguity of target nucleic acids is preserved, and the sequencing data obtained therefrom is used, but not limited to, identification of genomic variants, determination of contiguity information to inform assemblies of target nucleic acids de novo including deconvolution of haplotype phase information, and analyses of conformation and topology of target nucleic acids.

Abstract: Provided herein are methods and compositions for preparing sequencing templates that provide uniform genome coverage and preserve spatial-proximal contiguity information.

Abstract: Provided herein are methods and compositions for preparing nucleic acid templates wherein spatial-proximal and molecular contiguity of target nucleic acids is preserved, and the sequencing data obtained therefrom is used, but not limited to, identification of genomic variants, determination of contiguity information to inform assemblies of target nucleic acids de novo including deconvolution of haplotype phase information, and analyses of conformation and topology of target nucleic acids.

Abstract: An infusion device has a body, flexible wings and a needle projecting generally at right angles from one end of the body. A guard is pivoted to the one end of the body. On one side, the guard has a channel so that the guard overlies the body in a first position thereof during application of the needle to the patient. The guard is pivotable through about 180° to a position generally parallel to the body and on a side of the needle remote from the body. As the needle is withdrawn from the patient, the guard is pivoted about 90° further to receive the needle between one or more flexible contoured members along the opposite side of the guard. The needle is thus captured and encapsulated within the guard, with audible confirmation, the members precluding the guard from pivoting away from the needle.

Abstract: An infusion device has a body, flexible wings and a needle projecting generally at right angles from one end of the body. A guard is pivoted to the one end of the body. On one side, the guard has a channel so that the guard overlies the body in a first position thereof during application of the needle to the patient. The guard is pivotable through about 180° to a position generally parallel to the body and on a side of the needle remote from the body. As the needle is withdrawn from the patient, the guard is pivoted about 90° further to receive the needle between one or more flexible contoured members along the opposite side of the guard. The needle is thus captured and encapsulated within the guard, with audible confirmation, the members precluding the guard from pivoting away from the needle.