Abstract: In a magnetic resonance method and apparatus for determining a characteristic of an organ, a magnetic resonance sequence is executed in order to acquire temporally resolved magnetic resonance data pertaining to the organ. The magnetic resonance sequence includes at least one tagging module, which generates a sub-visual tag of the magnetic resonance data. The characteristic of the organ is determined in a processor using the sub-visual tag.

Abstract: The present invention relates to compounds of the Formula (I), or a pharmaceutically acceptable salt, pharmaceutical preparation, or pharmaceutical composition thereof, and their use for the treatment of pain, inflammatory disease, neuropathy, dermatological disorders, pulmonary conditions, and cough, as well as inhibiting the Transient Receptor Potential A1 ion channel (TRPA1).

Abstract: The present invention relates to compounds of the Formula (I), or a pharmaceutically acceptable salt, pharmaceutical preparation, or pharmaceutical composition thereof, and their use for the treatment of pain, inflammatory disease, neuropathy, dermatological disorders, pulmonary conditions, and cough, as well as inhibiting the Transient Receptor Potential A1 ion channel (TRPA1).

Abstract: In a magnetic resonance method and apparatus for determining a characteristic of an organ, a magnetic resonance sequence is executed in order to acquire temporally resolved magnetic resonance data pertaining to the organ. The magnetic resonance sequence includes at least one tagging module, which generates a sub-visual tag of the magnetic resonance data. The characteristic of the organ is determined in a processor using the sub-visual tag.

Abstract: The present invention relates to compounds of the Formula (I), or a pharmaceutically acceptable salt, pharmaceutical preparation, or pharmaceutical composition thereof, and their use for the treatment of pain, inflammatory disease, neuropathy, dermatological disorders, pulmonary conditions, and cough, as well as inhibiting the Transient Receptor Potential A1 ion channel (TRPA1).

Abstract: In a method and a magnetic resonance tomography system, at least two temporally separate original data sets are acquired with one phase measurement value being acquired for each pixel in each original image data set. An optimization technique for the shared calculation of corrected phase values for the pixels in the data sets is implemented in a computer, wherein the corrected phase values of the pixels in a first of the data sets is in each case dependent at least on the phase measured value of the pixel at the same location in a second of the data sets which is recorded beforehand or afterwards, and the corrected phase values of the pixels in the second data set are in each case dependent at least on the phase measured value of the pixel at the same place in the first data set. Corrected image data sets are generated from the corrected phase values.

Abstract: In a method for ascertaining a gradient correction value for magnetic resonance (MR) examinations with an MR apparatus, a measurement slice is selected, with the center of the measurement slice being located outside of the isocenter of the MR scanner of the MR apparatus. A radio-frequency pulse is applied simultaneously with a slice gradient. The radio-frequency pulse is switched off and a reslice gradient is applied. A measurement signal is acquired. A phase shift is determined from the measurement signal, and a gradient correction time or a gradient correction amplitude is calculated using the phase shift.

Abstract: In a method and a magnetic resonance tomography system, at least two temporally separate original data sets are acquired with one phase measurement value being acquired for each pixel in each original image data set. An optimization technique for the shared calculation of corrected phase values for the pixels in the data sets is implemented in a computer, wherein the corrected phase values of the pixels in a first of the data sets is in each case dependent at least on the phase measured value of the pixel at the same location in a second of the data sets which is recorded beforehand or afterwards, and the corrected phase values of the pixels in the second data set are in each case dependent at least on the phase measured value of the pixel at the same place in the first data set. Corrected image data sets are generated from the corrected phase values.

Abstract: This invention relates to solid forms of 2-(2,4-difluorophenyl)-6-(1-(2,6-difluorophenyl)ureido)nicotinamide and pharmaceutical compositions thereof, and methods and uses therewith.

Abstract: A method, system, and apparatus of determining optimal viewing planes for cardiac image acquisition, wherein the method includes acquiring a set of sagittal, axial, and coronal images of a heart, where the axial and coronal images intersect with the sagittal image orthogonally, and where the heart has a natural axis and a left ventricle (“LV”) with a bloodpool, a bloodpool border, and an apex. The method also includes making a map of the bloodpool border, and using the map to create a full coordinate frame oriented along the natural axis.

Abstract: The present invention relates to novel salts and methods useful as inhibitors of the nitric oxide synthase.

Abstract: A method and system for spatio-temporal (4D) modeling of an object includes sampling the 4-D model at one point in time to create a 3-D model. This 3-D model is then fit based on user-supplied guide points, image forces (e.g., image edges) and prior shape models. Once the 3-D model fit is completed the full 4-D shape model is updated. Cardiac images can be spatio-temporally modeled to determine LV conditions.

Abstract: The invention provides a method of measuring characteristics of an organ or part thereof from multiple images of the organ or part thereof, the method comprising the steps of defining the spatial position of at least two of the images; defining a reference model of the organ or part thereof scaled according to the distance between reference markers on the images; defining one or more boundary guide points associated with one or more images for which the spatial positions have been defined; converting the guide points to three-dimensional coordinates; defining an estimate model by fitting the reference model to the guide points; and calculating the characteristics from the estimate model. The invention also provides a system and a computer program for measuring characteristics of an organ or part thereof of a subject from multiple images of the subject's organ or part thereof.

Abstract: This invention relates to novel crystalline polymorphic forms of zaleplon (N-[3-(3-cyanopyrazolo[1,5a]pyrimidin-7-yl)phenyl]-N-ethylacetamide), methods for the preparation thereof; and their use as anxiolytic. antiepileptic. and sedative-hypnotic agents and skeletal muscle relaxants.

Abstract: A method and system for spatio-temporal (4D) modeling of an object includes sampling the 4-D model at one point in time to create a 3-D model. This 3-D model is then fit based on user-supplied guide points, image forces (e.g., image edges) and prior shape models. Once the 3-D model fit is completed the full 4-D shape model is updated. Cardiac images can be spatio-temporally modeled to determine LV conditions.

Abstract: A method, system, and apparatus of determining optimal viewing planes for cardiac image acquisition, wherein the method includes acquiring a set of sagittal, axial, and coronal images of a heart, where the axial and coronal images intersect with the sagittal image orthogonally, and where the heart has a natural axis and a left ventricle (“LV”) with a bloodpool, a bloodpool border, and an apex. The method also includes making a map of the bloodpool border, and using the map to create a full coordinate frame oriented along the natural axis.

Abstract: A system and method for acquisition-time modeling and automated post-processing are provided, where the system includes a processor, a user interface in signal communication with the processor for receiving preliminary scan data, a modeling unit in signal communication with the processor for fitting a model to the preliminary scan data, an imaging adapter in signal communication with the processor for receiving detailed scan data, and a detection unit in signal communication with the processor for detecting expected features in the detailed scan data; and the method includes receiving preliminary scan data, fitting a model to the preliminary scan data, receiving detailed scan data responsive to the model, and checking for expected features in the detailed scan data.

Abstract: A method and system for medical image acquisition are provided, where the method includes acquiring an image of the region of interest, acquiring a model for a region of interest, and fitting the model to the image; the system includes a modeling unit for modeling a region of interest; an acquisition unit in signal communication with the modeling unit for acquiring an image of the region of interest; and a fitting unit in signal communication with the acquisition unit for fitting the model to the image.

Abstract: This invention relates to novel crystalline polymorphic forms of zaleplon (N-[3-(3-cyanopyrazolo[1,5a]pyrimidin-7-yl)phenyl]-N-ethylacetamide), methods for the preparation thereof, and their use as anxiolytic, antiepileptic, and sedative-hypnotic agents and skeletal muscle relaxants.