Patents by Inventor Brett A. Tounge

Brett A. Tounge has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Substituted 3-dialkylaminomethyl-piperidin-4-yl-benzamides and methods of making and using same
    Patent number: 12162837
    Abstract: The invention relates to certain substituted 3-dialkylaminomethyl-piperidin-4-yl-benzamides, and compositions comprising the same, which in certain embodiments are useful for treating and/or preventing pain in a subject in need thereof.
    Type: Grant
    Filed: October 31, 2022
    Date of Patent: December 10, 2024
    Assignee: Mebias Discovery, Inc.
    Inventors: Brett A. Tounge, Shariff Bayoumy, Lawrence C. Kuo, Scott L Dax
  • SUBSTITUTED 3-DIALKYLAMINOMETHYL-PIPERIDIN-4-YL-BENZAMIDES AND METHODS OF MAKING AND USING SAME
    Publication number: 20240043387
    Abstract: The invention relates to certain substituted 3-dialkylaminomethyl-piperidin-4-yl-benzamides, and compositions comprising the same, which in certain embodiments are useful for treating and/or preventing pain in a subject in need thereof.
    Type: Application
    Filed: October 31, 2022
    Publication date: February 8, 2024
    Inventors: Brett A. Tounge, Shariff Bayoumy, Lawrence C. Kuo, Scott L. Dax
  • Substituted Ureas and Methods of Making and Using Same
    Publication number: 20220315567
    Abstract: The invention relates to substituted ureas, and compositions comprising the same, which in certain embodiments are useful for treating and/or preventing pain in a subject in need thereof.
    Type: Application
    Filed: November 5, 2021
    Publication date: October 6, 2022
    Inventors: Brett A. Tounge, Shariff Bayoumy, Lawrence C. Kuo, Scott Dax
  • Substituted 3-dialkylaminomethyl-piperidin-4-yl-benzamides and methods of making and using same
    Patent number: 11319290
    Abstract: The invention relates to certain substituted 3-dialkylaminomethyl-piperidin-4-yl-benzamides, and compositions comprising the same, which in certain embodiments are useful for treating and/or preventing pain in a subject in need thereof.
    Type: Grant
    Filed: September 18, 2020
    Date of Patent: May 3, 2022
    Assignee: Mebias Discovery, Inc.
    Inventors: Brett A. Tounge, Shariff Bayoumy, Lawrence C. Kuo, Scott L. Dax
  • Substituted ureas and methods of making and using same
    Patent number: 11198685
    Abstract: The invention relates to substituted ureas, and compositions comprising the same, which in certain embodiments are useful for treating and/or preventing pain in a subject in need thereof.
    Type: Grant
    Filed: May 18, 2020
    Date of Patent: December 14, 2021
    Assignee: Mebias Discovery, Inc.
    Inventors: Brett A. Tounge, Shariff Bayoumy, Lawrence C. Kuo, Scott Dax
  • Substituted 3-Dialkylaminomethyl-Piperidin-4-yl-Benzamides and Methods of Making and Using Same
    Publication number: 20210101868
    Abstract: The invention relates to certain substituted 3-dialkylaminomethyl-piperidin-4-yl-benzamides, and compositions comprising the same, which in certain embodiments are useful for treating and/or preventing pain in a subject in need thereof.
    Type: Application
    Filed: September 18, 2020
    Publication date: April 8, 2021
    Inventors: Brett A. Tounge, Shariff Bayoumy, Lawrence C. Kuo, Scott L. Dax
  • Substituted 3-dialkylaminomethyl-piperidin-4-yl-benzamides and methods of making and using same
    Patent number: 10836728
    Abstract: The invention relates to certain substituted 3-dialkylaminomethyl-piperidin-4-yl-benzamides, and compositions comprising the same, which in certain embodiments are useful for treating and/or preventing pain in a subject in need thereof.
    Type: Grant
    Filed: January 17, 2018
    Date of Patent: November 17, 2020
    Assignee: Mebias Discovery, Inc.
    Inventors: Brett A. Tounge, Shariff Bayoumy, Lawrence C. Kuo, Scott L. Dax
  • Substituted Ureas and Methods of Making and Using Same
    Publication number: 20200308155
    Abstract: The invention relates to substituted ureas, and compositions comprising the same, which in certain embodiments are useful for treating and/or preventing pain in a subject in need thereof.
    Type: Application
    Filed: May 18, 2020
    Publication date: October 1, 2020
    Inventors: Brett A. Tounge, Shariff Bayoumy, Lawrence C. Kuo, Scott Dax
  • Substituted ureas and methods of making and using same
    Patent number: 10683283
    Abstract: The invention relates to substituted ureas, and compositions comprising the same, which in certain embodiments are useful for treating and/or preventing pain in a subject in need thereof.
    Type: Grant
    Filed: August 31, 2017
    Date of Patent: June 16, 2020
    Assignee: MEBIAS DISCOVERY, INC.
    Inventors: Brett A. Tounge, Shariff Bayoumy, Lawrence C. Kuo, Scott Dax
  • Methods of treatment using allosteric processing inhibitors for matrix metalloproteinases
    Patent number: 8883473
    Abstract: The present invention includes a crystal comprising a complex of the pro form of a matrix metalloprotease (proMMP) and a small-molecule allosteric processing inhibitor that inhibits that activation of the proMMP, methods for identifying small-molecule allosteric processing inhibitors that inhibit the activation of a proMMP, and methods of treatment using small-molecule allosteric processing inhibitors that inhibit the activation of a proMMP. The present invention relates to the crystal structure of a complex of proMMP9 bound to a small-molecule allosteric processing inhibitor that inhibits activation of proMMP9. The invention further relates to the use of the methods and the crystal and related structural information for designing, selecting and/or optimizing small-molecule allosteric processing inhibitors that inhibit activation of proMMP9 and proMMP9 homologues.
    Type: Grant
    Filed: June 26, 2012
    Date of Patent: November 11, 2014
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Kristi A. Leonard, Richard Scott Alexander, Joseph Kent Barbay, Roger F. Bone, Carl Crysler, Ingrid Christa Deckman, Paul F. Jackson, Lawrence C. Kuo, Frank A. Lewandowski, Diane M. Maguire, Carl Manthey, Cynthia M. Milligan, Beverley Moore, Kenneth J. Rhodes, Robert H. Scannevin, Celine Schalk-Hihi, Barry Springer, John C. Spurlino, Matthew J. Todd, Brett A. Tounge, Aihua Wang
  • Methods for designing, selecting and/or optimizing allosteric processing inhibitors for matrix metalloproteinases
    Patent number: 8798939
    Abstract: The present invention includes a crystal comprising a complex of the pro form of a matrix metalloprotease (proMMP) and a small-molecule allosteric processing inhibitor that inhibits that activation of the proMMP, methods for identifying small-molecule allosteric processing inhibitors that inhibit the activation of a proMMP, and methods of treatment using small-molecule allosteric processing inhibitors that inhibit the activation of a proMMP. The present invention relates to the crystal structure of a complex of proMMP9 bound to a small-molecule allosteric processing inhibitor that inhibits activation of proMMP9. The invention further relates to the use of the methods and the crystal and related structural information for designing, selecting and/or optimizing small-molecule allosteric processing inhibitors that inhibit activation of proMMP9 and proMMP9 homologues.
    Type: Grant
    Filed: June 26, 2012
    Date of Patent: August 5, 2014
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Kristi A. Leonard, Richard Scott Alexander, Joseph Kent Barbay, Roger F. Bone, Ingrid Christa Deckman, Paul F. Jackson, Lawrence C. Kuo, Frank A. Lewandowski, Diane M. Maguire, Cynthia M. Milligan, Kenneth J. Rhodes, Robert H. Scannevin, Celine Schalk-Hihi, Barry Springer, John C. Spurlino, Matthew J. Todd, Brett A. Tounge, Aihua Wang
  • Crystal structure of the pro form of a matrix metalloproteinase and an allosteric processing inhibitor
    Patent number: 8753857
    Abstract: The present invention includes a crystal comprising a complex of the pro form of a matrix metalloprotease (proMMP) and a small-molecule allosteric processing inhibitor that inhibits that activation of the proMMP, methods for identifying small-molecule allosteric processing inhibitors that inhibit the activation of a proMMP, and methods of treatment using small-molecule allosteric processing inhibitors that inhibit the activation of a proMMP. The present invention relates to the crystal structure of a complex of proMMP9 bound to a small-molecule allosteric processing inhibitor that inhibits activation of proMMP9. The invention further relates to the use of the methods and the crystal and related structural information for designing, selecting and/or optimizing small-molecule allosteric processing inhibitors that inhibit activation of proMMP9 and proMMP9 homologues.
    Type: Grant
    Filed: June 26, 2012
    Date of Patent: June 17, 2014
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Kristi A. Leonard, Richard Scott Alexander, Joseph Kent Barbay, Roger F. Bone, Ingrid Christa Deckman, Paul F. Jackson, Lawrence C. Kuo, Frank A. Lewandowski, Diane M. Maguire, Cynthia M. Milligan, Kenneth J. Rhodes, Robert H. Scannevin, Celine Schalk-Hihi, Barry Springer, John C. Spurlino, Matthew J. Todd, Brett A. Tounge, Aihua Wang
  • Alkynyl derivatives useful as DPP-1 inhibitors
    Patent number: 8633322
    Abstract: The present invention is directed to novel alkynyl derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by DPP-1.
    Type: Grant
    Filed: October 28, 2010
    Date of Patent: January 21, 2014
    Assignee: Janssen Pharmaceutica NV
    Inventors: Michael H. Parker, Dennis J. Hlasta, Yifang Huang, Allen B. Reitz, Edward C. Lawson, Carsten Schubert, Eric Strobel, Brett A. Tounge, Kimberly White, Michael P. Winters, Shyamali Ghosh
  • 2-amino-quinazoline derivatives useful as inhibitors of ?-secretase (BACE)
    Patent number: 8383637
    Abstract: The present invention is directed to novel 2-amino-3,4-dihydro-quinazoline derivatives, pharmaceutical compositions containing them and their use in the treatment of Alzheimer's disease (AD) and related disorders. The compounds of the invention are inhibitors of ?-secretase, also known as ?-site cleaving enzyme and BACE.
    Type: Grant
    Filed: August 4, 2005
    Date of Patent: February 26, 2013
    Assignee: Jansssen Pharmaceutica N.V.
    Inventors: Ellen Baxter, Francois Paul Bischoff, Robert E. Boyd, Mirielle Braeken, Steve Coats, Yifang Huang, Alfonzo D. Jordan, Chi Luo, Marc Hubert Mercken, Serge Maria Aloysius Pieters, Allen B. Reitz, Charles H. Reynolds, Tina Morgan Ross, Brett A. Tounge, Mark J. Schulz, Hans Louis Jos De Winter
  • ALKYNYL DERIVATIVES USEFUL AS DPP-1 INHIBITORS
    Publication number: 20110105562
    Abstract: The present invention is directed to novel alkynyl derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by DPP-1.
    Type: Application
    Filed: October 28, 2010
    Publication date: May 5, 2011
    Inventors: Michael H. Parker, Dennis J. Hlasta, Yifang Huang, Allen B. Reitz, Edward C. Lawson, Carsten Schubert, Eric Strobel, Brett A. Tounge, Kimberly White, Michael P. Winters, Shyamali Ghosh
  • 2-amino-quinoline derivatives useful as inhibitors of ?-secretase (BACE)
    Patent number: 7868022
    Abstract: The present invention is directed to 2-amino-quinoline derivatives, pharmaceutical compositions containing them and their use in the treatment of Alzheimer's disease (AD) and related disorders. The compounds of the invention are inhibitors of ?-secretase, also known as ?-site cleaving enzyme and BACE, BACE1, Asp2 and memapsin2.
    Type: Grant
    Filed: February 6, 2007
    Date of Patent: January 11, 2011
    Assignee: Janssen Pharmaceutica NV
    Inventors: Ellen Baxter, Allen B. Reitz, Umar Saibu Mohomed Maharoof, Yifang Huang, Christopher John Creighton, Charles H. Reynolds, Chi Luo, Brett A. Tounge, Tina Morgan Ross, Tianbao Lu
  • 2-amino-3,4-dihydro-pyrido[3,4-d]pyrimidine derivatives useful as inhibitors of ?-secretase (BACE)
    Patent number: 7531545
    Abstract: The present invention is directed to novel 2-amino-3,4-dihydro-pyrido[3,4-d]pyrimidine derivatives, pharmaceutical compositions containing them and their use in the treatment of Alzheimer's disease (AD) and related disorders. The compounds of the invention are inhibitors of ?-secretase, also known as ?-site cleaving enzyme and BACE, BACE1, Asp2 and memapsin2.
    Type: Grant
    Filed: October 25, 2006
    Date of Patent: May 12, 2009
    Assignee: Janssen Pharmaceutica, N.V.
    Inventors: Ellen E. Baxter, Christopher John Creighton, Yifang Huang, Chi Luo, Michael H. Parker, Allen B. Reitz, Charles H. Reynolds, Tina Morgan Ross, Eric D. Strobel, Brett A. Tounge
  • 2-AMINO-QUINOLINE DERIVATIVES USEFUL AS INHIBITORS OF BETA-SECRETASE (BACE)
    Publication number: 20080194624
    Abstract: The present invention is directed to 2-amino-quinoline derivatives, pharmaceutical compositions containing them and their use in the treatment of Alzheimer's disease (AD) and related disorders. The compounds of the invention are inhibitors of ?-secretase, also known as ?-site cleaving enzyme and BACE, BACE1, Asp2 and memapsin2.
    Type: Application
    Filed: February 6, 2007
    Publication date: August 14, 2008
    Inventors: Ellen Baxter, Allen B. Reitz, Umar Saibu Mohomed Maharoof, Yifang Huang, Christopher John Creighton, Charles H. Reynolds, Chi Luo, Brett A. Tounge, Tina Morgan Ross, Tianbao Lu