Patents by Inventor Brett A. Trauthen
Brett A. Trauthen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230210693Abstract: A method of delivering a pharmaceutical composition to Schlemm’s canal of an eye is disclosed. The method may comprise inserting a drug delivery device in conjunction with a microstent into Schlemm’s canal. The drug delivery device may comprise a bioerodable polymer and a pharmaceutical composition, and the drug delivery device may be configured to erode over time and to elute the pharmaceutical composition into aqueous humor within Schlemm’s canal as it erodes.Type: ApplicationFiled: January 5, 2023Publication date: July 6, 2023Inventor: Brett A. TRAUTHEN
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Patent number: 9101501Abstract: Disclosed is a stent that is useful for treating a vascular bifurcation, the stent having a plurality of segments extending coaxially end to end along a longitudinal axis of the stent from a first end to a second end of the stent, each segment having a plurality of struts extending in a zig-zag pattern around the circumference of the stent, wherein the stent is expandable from reduced diameter to an expanded diameter, the second end of the stent having a larger diameter than the first end when expanded; and an eyelet integrally formed with the segment positioned adjacent the second end, and configured to receive a radiopaque marker therein. The stent provides an improvement over prior stents for treating a vascular bifurcation by allowing the stent to be deployed in the widened transitional zone of a bifurcation such that the second end of the stent is accurately positioned at the carina.Type: GrantFiled: March 30, 2010Date of Patent: August 11, 2015Assignee: Biosensors International Group, Ltd.Inventors: Jean-Claude Laborde, Robert John Elicker, Brett Trauthen, Jacques Seguin
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Publication number: 20100256744Abstract: A method of deploying a bifurcation stent at a vascular bifurcation of a main vessel into first and second branch vessels includes: positioning a bifurcation stent at a vascular bifurcation, the bifurcation stent expandable from a reduced diameter to an expanded diameter, the bifurcation stent comprising a first end, a second end, and a marker near the first end, wherein the first end diameter is larger than the second end diameter when the bifurcation stent is expanded, and wherein the bifurcation stent is positioned such that the marker is approximately aligned with a carinal plane at the vascular bifurcation; partially expanding the first end of the bifurcation stent; adjusting the position of the bifurcation stent such that the marker is positioned past the carinal plane and towards the first branch vessel; and deploying the bifurcation stent at the bifurcation. Devices are also disclosed.Type: ApplicationFiled: March 30, 2010Publication date: October 7, 2010Inventors: Jean-Claude Laborde, Robert John Elicker, Brett Trauthen, Jacques Seguin
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Patent number: 7686846Abstract: A method of deploying a bifurcation stent at a vascular bifurcation of a main vessel into first and second branch vessels includes: positioning a bifurcation stent at a vascular bifurcation, the bifurcation stent expandable from a reduced diameter to an expanded diameter, the bifurcation stent comprising a first end, a second end, and a marker near the first end, wherein the first end diameter is larger than the second end diameter when the bifurcation stent is expanded, and wherein the bifurcation stent is positioned such that the marker is approximately aligned with a carinal plane at the vascular bifurcation; partially expanding the first end of the bifurcation stent; adjusting the position of the bifurcation stent such that the marker is positioned past the carinal plane and towards the first branch vessel; and deploying the bifurcation stent at the bifurcation. Devices are also disclosed.Type: GrantFiled: April 19, 2007Date of Patent: March 30, 2010Assignee: Devax, Inc.Inventors: Jean-Claude Laborde, Robert John Elicker, Brett Trauthen, Jacques Seguin
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Publication number: 20080200974Abstract: A self-expanding stent providing a high compliance mismatch upon initial placement, to exert radially outward force over the course of several weeks or months until it reaches the limits of expansion as imposed by a limiting mechanism, and thereafter provide high resistance to inward radial forces exerted by the artery without exerting additional outward radial force on the artery. The stent is coated with a compound including an MMPI, in a formulation in which the MMPI is substantially exhausted over the course of several weeks or months, to be substantially coincident with expansion of the stent to its stop limited diameter.Type: ApplicationFiled: February 15, 2007Publication date: August 21, 2008Inventors: Brett A. Trauthen, Stefan Verheye
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Publication number: 20080046072Abstract: A method of deploying a bifurcation stent at a vascular bifurcation of a main vessel into first and second branch vessels includes: positioning a bifurcation stent at a vascular bifurcation, the bifurcation stent expandable from a reduced diameter to an expanded diameter, the bifurcation stent comprising a first end, a second end, and a marker near the first end, wherein the first end diameter is larger than the second end diameter when the bifurcation stent is expanded, and wherein the bifurcation stent is positioned such that the marker is approximately aligned with a carinal plane at the vascular bifurcation; partially expanding the first end of the bifurcation stent; adjusting the position of the bifurcation stent such that the marker is positioned past the carinal plane and towards the first branch vessel; and deploying the bifurcation stent at the bifurcation. Devices are also disclosed.Type: ApplicationFiled: April 19, 2007Publication date: February 21, 2008Inventors: Jean-Claude Laborde, Robert Elicker, Brett Trauthen, Jacques Seguin
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Publication number: 20060178734Abstract: A method for decreasing the level of restenosis following a stent placement medical intervention involves the continuous administration of a dose of an anti-restenotic agent, such as paclitaxel, from the stent to vascular tissue in need of treatment in a controlled, extended, and substantially linear drug release profile. The method of substantially linear extended release increases the therapeutic effectiveness of administration of a given dosage. In one example, a method of reducing restenosis includes delivering paclitaxel from a stent to an artery at a minimum release rate of 1 percent of the total dosage of paclitaxel on the stent per day throughout an entire administration period from the time of implantation of the stent until the time that substantially all the paclitaxel is released from the stent.Type: ApplicationFiled: January 4, 2006Publication date: August 10, 2006Applicant: Conor Medsystems, Inc.Inventors: Theodore Parker, John Shanley, Brett Trauthen, Frank Litvack, Stephen Diaz
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Publication number: 20040204756Abstract: A method for decreasing the level of restenosis following a stent placement medical intervention involves the continuous administration of a dose of an anti-restenotic agent , such as paclitaxel, from the stent to vascular tissue in need of treatment in a controlled, extended ,and substantially linear drug release profile. The method of substantially linear extended release increases the therapeutic effectiveness of administration of a given dosage. In one example, a method of reducing restenosis includes delivering paclitaxel from a stent to an artery at a minimum release rate of 1 percent of the total dosage of paclitaxel on the stent per day throughout an entire administration period from the time of implantation of the stent until the time that substantially all the paclitaxel is released from the stent.Type: ApplicationFiled: February 11, 2004Publication date: October 14, 2004Inventors: Stephen Hunter Diaz, Theodore L Parker, John F Shanley, Brett Trauthen, Frank Litvack
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Patent number: 6685618Abstract: Disclosed is a thin film radiation source, which may be used to deliver a radioactive dose to a site in a body lumen. The source comprises a thin flexible substrate, and a layer of radioisotope attached thereto. The source may further comprise additional layers such as one or more tie layers disposed between the substrate and the radioisotope layer and one or more outer coating layers. In one embodiment, the source is wrapped around an inflatable balloon. Inflation of the balloon at a treatment site positions the source directly adjacent to the vessel wall, and allows irradiation of the site following or simultaneously with a balloon angioplasty, stent implantation, or stent sizing procedure.Type: GrantFiled: August 31, 2001Date of Patent: February 3, 2004Assignee: Endologix, Inc.Inventors: Lisa A. Tam, Brett A. Trauthen
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Publication number: 20030208096Abstract: Disclosed is a thin film radiation source, which may be used to deliver a radioactive dose to a site in a body lumen. The source comprises a thin flexible substrate, and a layer of radioisotope attached thereto. The source may further comprise additional layers such as one or more tie layers disposed between the substrate and the radioisotope layer and one or more outer coating layers. In one embodiment, the source is wrapped around an inflatable balloon. Inflation of the balloon at a treatment site positions the source directly adjacent to the vessel wall, and allows irradiation of the site following or simultaneously with a balloon angioplasty, stent implantation, or stent sizing procedure.Type: ApplicationFiled: August 31, 2001Publication date: November 6, 2003Inventors: Lisa A. Tam, Brett A. Trauthen
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Publication number: 20030166990Abstract: Disclosed are sources and methods for delivering a radioactive dose to a site in a body lumen. The sources are preferably mounted on a balloon or other expandable or deployable mechanical structure. The source and methods enable delivery of a clinically significant dose of radiation into a vessel wall in a relatively short time while using a relatively low activity. The sources also enable delivery of a substantially uniform dose into the vessel wall, whether or not such delivery is through the wall of a stent.Type: ApplicationFiled: December 9, 2002Publication date: September 4, 2003Inventors: Brett Trauthen, Lisa Tam, Robert Fazio, Michael Crocker, Edward F. Smith, Gary Strathern
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Publication number: 20030163017Abstract: Disclosed is a sealed radiation source, which may be used to deliver a radioactive dose to a site in a body lumen. The source comprises a thin flexible substrate, and a layer of radioisotope attached thereto. The source may further comprise additional layers such as one or more tie layers disposed between the substrate and the radioisotope layer and one or more outer coating layers. In one embodiment, the source is wrapped around an inflatable balloon. Inflation of the balloon at a treatment site positions the source directly adjacent to the vessel wall, and allows irradiation of the site following or simultaneously with a balloon angioplasty, stent implantation, or stent sizing procedure.Type: ApplicationFiled: October 1, 2002Publication date: August 28, 2003Inventors: Lisa A. Tam, Brett A. Trauthen
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Patent number: 6491619Abstract: Disclosed are sources and methods for delivering a radioactive dose to a site in a body lumen. The sources are preferably mounted on a balloon or other expandable or deployable mechanical structure. The source and methods enable delivery of a clinically significant dose of radiation into a vessel wall in a relatively short time while using a relatively low activity. The sources also enable delivery of a substantially uniform dose into the vessel wall, whether or not such delivery is through the wall of a stent.Type: GrantFiled: August 25, 2000Date of Patent: December 10, 2002Assignee: Endologix, IncInventors: Brett Trauthen, Lisa Tam, Robert Fazio, Michael Crocker, Edward F. Smith, Gary Strathern
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Patent number: 6458069Abstract: A sealed radiation source, which may be used to deliver a radioactive dose to a site in a body lumen. The source comprises a thin flexible substrate, and a layer of radioisotope attached thereto. The source may further comprise additional layers such as one or more tie layers disposed between the substrate and the radioisotope layer and one or more outer coating layers. In one embodiment, the source is wrapped around an inflatable balloon. Inflation of the balloon at a treatment site positions the source directly adjacent to the vessel wall, and allows irradiation of the site following or simultaneously with a balloon angioplasty, stent implantation, or stent sizing procedure.Type: GrantFiled: August 24, 1999Date of Patent: October 1, 2002Assignee: Endology, INC.Inventors: Lisa A. Tam, Brett A. Trauthen
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Patent number: 6287249Abstract: Disclosed is a thin film radiation source, which may be used to deliver a radioactive dose to a site in a body lumen. The source comprises a thin flexible substrate, and a layer of radioisotope attached thereto. The source may further comprise additional layers such as one or more tie layers disposed between the substrate and the radioisotope layer and one or more outer coating layers. In one embodiment, the source is wrapped around an inflatable balloon. Inflation of the balloon at a treatment site positions the source directly adjacent to the vessel wall, and allows irradiation of the site following or simultaneously with a balloon angioplasty, stent implantation, or stent sizing procedure.Type: GrantFiled: February 19, 1999Date of Patent: September 11, 2001Assignee: Radiance Medical Systems, Inc.Inventors: Lisa A. Tam, Brett A. Trauthen
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Patent number: 6261320Abstract: Disclosed is a radioactive tubular prosthesis formed by rolling a flexible sheet around a longitudinal axis. Preferably, the prosthesis is self expandable under the radially outwardly directed spring bias of the rolled sheet. At least a portion of the sheet is provided with a coating comprising at least one radioisotope.Type: GrantFiled: February 19, 1999Date of Patent: July 17, 2001Assignee: Radiance Medical Systems, Inc.Inventors: Lisa A. Tam, Brett A. Trauthen
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Patent number: 6149574Abstract: Disclosed is a dual catheter radiation delivery system, for delivering a dose of radiation to a treatment site, typically in a body lumen. The system comprises an outer sheath catheter, having an inflatable balloon thereon. The system further comprises an inner radiation delivery catheter, having a radially expandable structure such as a balloon with a radiation source thereon. The sheath catheter is positioned such that the sheath balloon is at the treatment site, and the radiation delivery catheter is transluminally advanced through the sheath catheter such that the radiation source is positioned within the sheath balloon. The radiation delivery balloon is inflated within the sheath balloon, to position the radioactive source near the vessel wall. The source may comprise a thin film carried by the radiation delivery balloon, having a radioactive isotope implanted therein or chemically bonded thereto. Alternatively, the radioactive isotope may be implanted within or adhered to the radiation delivery balloon.Type: GrantFiled: March 17, 1998Date of Patent: November 21, 2000Assignee: Radiance Medical Systems, Inc.Inventors: Brett Trauthen, Paul McCormick, Maurice Buchbinder, Michael Henson
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Patent number: 6059748Abstract: An exchange catheter facilitates the replacement of an existing guiding catheter with a larger guiding catheter during catheterization procedures such as percutaneous transluminal coronary angioplasty without disturbing the position of a guidewire. The exchange catheter has a distal portion through which a guidewire is slidable. The outer diameter of the distal portion is slightly less than the inner diameter of the existing guiding catheter. A femoral sheath is slidable over the proximal portion of the exchange catheter so as to facilitate femoral sheath exchange.Type: GrantFiled: November 7, 1997Date of Patent: May 9, 2000Assignee: Advanced Cardiovascular Systems, Inc.Inventors: Paul Teirstein, Brett Trauthen, Mark Hall
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Patent number: 5954732Abstract: A suturing apparatus adapted to close an incision and an anterior tissue wall includes an elongate support structure having an axis extending between a proximal end and distal end. A receiver disposed at the distal end is insertable through the incision in a low-profile state and expanded to a high-profile state on the far side of the tissue wall. Needles carried by the support structure are operable to extend through the support wall on either side of the incision and into the expanded receiver. Sutures advanced through the needles are captured by the receiver after the needles are removed and the receiver is returned to its low-profile state. Removal of the suturing apparatus from the incision draws the captured suture ends outwardly through the incision. A novel suture knot can be tied in the four suture ends and moved into proximity with the tissue wall to close the incision.Type: GrantFiled: September 10, 1997Date of Patent: September 21, 1999Inventors: Charles C. Hart, Brett Trauthen, Nabil Hilal, Said Hilal, Bounsavanh Pravongviengkham
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Patent number: 5693015Abstract: A balloon catheter includes a flexible small-diameter guide wire provided with an enlarged-diameter distal end portion, and a flexible elongated tubular shaft with at least one dual-function fluid-conducting lumen adapted to both receive the guide wire extending therethrough, and to communicate pressurized inflation fluid to a distal balloon of the catheter. A distal orifice of the catheter communicates with the balloon and is provided with selective valving means for releasably engaging sealingly with the enlarged distal end portion of the guide wire. Apparatus is disclosed for axially moving the guide wire to effect engagement and disengagement of the enlarged distal end portion with the selective valving means of the catheter shaft. A torquer device is also provided by means of which the guide wire may be rotated relative to the catheter shaft for steering of the guide wire along a vascular pathway.Type: GrantFiled: June 6, 1995Date of Patent: December 2, 1997Assignee: Advanced Cardiovascular Systems, Inc.Inventors: Blair Walker, Manouchehr Miraki, William Rice, Kambiz Ghearzadeh, Brett Trauthen, Hye Lee, Greg Welsh, Henry Nita, Shawn O'Leary