Abstract: The present disclosure provides a class of compounds including a ligand moiety that specifically binds to a cell surface asialoglycoprotein receptor (ASGPR). The cell surface ASGPR binding compounds can trigger the receptor to internalize into the cell a bound compound. The ligand moieties of this disclosure can be linked to a variety of moieties of interest without impacting the specific binding to, and function of, the cell surface receptor ASGPR. Also provided are compounds that are conjugates of the ligand moieties linked to a biomolecule, such as an antibody, which conjugates can harness cellular pathways to remove specific proteins of interest from the cell surface or from the extracellular milieu. Also provided herein methods of using the conjugates to target a polypeptide of interest for sequestration and/or lysosomal degradation.

Abstract: The parameters of an optical code are optimized to achieve improved signal robustness, reliability, capacity and/or visual quality. An optimization program can determine spatial density, dot distance, dot size and signal component priority to optimize robustness. An optical code generator employs these parameters to produce an optical code at the desired spatial density and robustness. The optical code is merged into a host image, such as imagery, text and graphics of a package or label, or it may be printed by itself, e.g., on an otherwise blank label or carton. A great number of other features and arrangements are also detailed.

Abstract: The present disclosure provides a class of compounds including a ligand moiety that specifically binds to a cell surface asialoglycoprotein receptor (ASGPR). The cell surface ASGPR binding compounds can trigger the receptor to internalize into the cell a bound compound. The ligand moieties of this disclosure can be linked to a variety of moieties of interest without impacting the specific binding to, and function of, the cell surface receptor ASGPR. Also provided are compounds that are conjugates of the ligand moieties linked to a biomolecule, such as an antibody, which conjugates can harness cellular pathways to remove specific proteins of interest from the cell surface or from the extracellular milieu. Also provided herein methods of using the conjugates to target a polypeptide of interest for sequestration and/or lysosomal degradation.

Abstract: The present disclosure provides a class of compounds including a ligand moiety that specifically binds to a cell surface mannose-6-phosphate receptor (M6PR). The M6PR binding compounds can trigger the receptor to internalize into the cell a bound compound. The ligand moieties of this disclosure can be linked to a variety of moieties of interest without impacting the specific binding to, and function of, the M6PR. Also provided are compound that are conjugates of the ligand moieties linked to a biomolecule, such as an antibody, which conjugates can harness cellular pathways to remove specific target proteins from the cell surface or the extracellular milieu. For example, the conjugates described herein may sequester and/or degrade a target molecule of interest in a cell's lysosome. Also provided are methods of using the conjugates to target a protein for sequestration and/or lysosomal degradation.

Abstract: The parameters of an optical code are optimized to achieve improved signal robustness, reliability, capacity and/or visual quality. An optimization program can determine spatial density, dot distance, dot size and signal component priority to optimize robustness. An optical code generator employs these parameters to produce an optical code at the desired spatial density and robustness. The optical code is merged into a host image, such as imagery, text and graphics of a package or label, or it may be printed by itself, e.g., on an otherwise blank label or carton. A great number of other features and arrangements are also detailed.

Abstract: A duplex visual tester for testing multiple fiber optic cable runs includes a housing having a first LED and a second LED in a duplex fiber connection. The first LED and the second LED are in electronic communication with a power source, a battery, an on/off switch, and a timer configured to pulse the first LED and the second LED. The first LED and the second LED are installed in the duplex fiber connection. The first LED has a first color, and the second LED has a second, different color, wherein the first color and the second color have the same luminosity. Preferably, the timer pulses the first LED and the second LED at between eight and ten Hz, such that the first color and second color can be seen in the fiber optic cable run.

Abstract: The present disclosure provides a class of compounds including a ligand moiety that specifically binds to a cell surface receptor, such as a folate receptor. The cell surface folate binding compound can trigger the receptor to internalize into the cell a bound compound. The ligand moieties of this disclosure can be linked to a variety of moieties of interest without impacting the specific binding to, and function of, the cell surface receptor, e.g., folate receptor. Also provided are compounds that are conjugates of the ligand moieties linked to a biomolecule, such as an antibody, which conjugates can harness cellular pathways to remove specific proteins of interest from the cell surface or from the extracellular milieu. Also provided herein are methods of using the conjugates to target a polypeptide of interest for sequestration and/or lysosomal degradation.

Abstract: Audio signal processing enhances audio watermark embedding and detecting processes. Audio signal processes include audio classification and adapting watermark embedding and detecting based on classification. Advances in audio watermark design include adaptive watermark signal structure data protocols, perceptual models, and insertion methods. Perceptual and robustness evaluation is integrated into audio watermark embedding to optimize audio quality relative the original signal, and to optimize robustness or data capacity. These methods are applied to audio segments in audio embedder and detector configurations to support real time operation. Feature extraction and matching are also used to adapt audio watermark embedding and detecting.

Abstract: The present disclosure relates to advanced image signal processing technology including: i) rapid localization for machine-readable indicia including, e.g., 1-D and 2-D barcodes; and ii) barcode reading and decoders. One claim recites: an image processing method comprising: obtaining 2-dimensional (2D) image data representing a 1-dimensional (1D) barcode within a first image area; generating a plurality of scanlines across the first image area; for each of the plurality of scanlines, synchronizing the scanline, including decoding an initial set of numerical digits represented by the scanline, in which said synchronizing provides a scale estimate for the scanline; using a path decoder to decode remaining numerical digits within the scanline, the path decoder decoding multiple numerical digits in groups, in which the scale estimate is adapted as the remaining numerical digits are decoded; and providing decoded numerical digits as an identifier represented by the scanline.

Abstract: A duplex visual tester for testing multiple fiber optic cable runs includes a housing having a first LED and a second LED in a duplex fiber connection. The first LED and the second LED are in electronic communication with a power source, a battery, an on/off switch, and a timer configured to pulse the first LED and the second LED. The first LED and the second LED are installed in the duplex fiber connection. The first LED has a first color, and the second LED has a second, different color, wherein the first color and the second color have the same luminosity. Preferably, the timer pulses the first LED and the second LED at between eight and ten Hz, such that the first color and second color can be seen in the fiber optic cable run.

Abstract: The present disclosure provides a class of compounds including a ligand moiety that specifically binds to a cell surface asialoglycoprotein receptor (ASGPR). The cell surface ASGPR binding compounds can trigger the receptor to internalize into the cell a bound compound. The ligand moieties of this disclosure can be linked to a variety of moieties of interest without impacting the specific binding to, and function of, the cell surface receptor ASGPR. Also provided are compounds that are conjugates of the ligand moieties linked to a biomolecule, such as an antibody, which conjugates can harness cellular pathways to remove specific proteins of interest from the cell surface or from the extracellular milieu. Also provided herein methods of using the conjugates to target a polypeptide of interest for sequestration and/or lysosomal degradation.

Abstract: The present disclosure provides a class of compounds including a ligand moiety that specifically binds to a cell surface receptor, such as a mannose-6-phosphate receptor (M6PR) or a cell surface asialoglycoprotein receptor (ASGPR). The cell surface M6PR or ASGPR binding compounds can trigger the receptor to internalize into the cell abound compound. The ligand moieties of this disclosure can be linked to a variety of moieties of interest without impacting the specific binding to, and function of, the cell surface receptor, e.g., M6PR or ASGPR. Also provided are compounds that are conjugates of the ligand moieties linked to a biomolecule, such as an antibody, which conjugates can harness cellular pathways to remove specific proteins of interest from the cell surface or from the extracellular milieu. Also provided are methods of using the conjugates to target a polypeptide of interest for sequestration and/or lysosomal degradation.

Abstract: Mobile device positioning employs various forms of audio signal structures and detection methodologies. In one method, detection of an audio signal from a first source enables construction of a signal to facilitate detection of an audio signal from another source. Signals detected from these sources enable positioning of the mobile device receiving those signals. Another method forms audio signals transmitted from audio sources so that they have parts that add constructively and parts that differentiate the sources to enable positioning. Another audio signal based positioning method adaptively switches among positioning methods so that positioning remains operative as a mobile device moves toward and away from the sources. Another method tracks positioning history, evaluates it for errors and performs error mitigation to improve accuracy. Various other positioning technologies are detailed as well.

Abstract: The present disclosure relates to advanced image signal processing technology including: i) rapid localization for machine-readable indicia including, e.g., 1-D and 2-D barcodes; and ii) barcode reading and decoders. One claim recites: an image processing method comprising: obtaining 2-dimensional (2D) image data representing a 1-dimensional (1D) barcode within a first image area; generating a plurality of scanlines across the first image area; for each of the plurality of scanlines, synchronizing the scanline, including decoding an initial set of numerical digits represented by the scanline, in which said synchronizing provides a scale estimate for the scanline; using a path decoder to decode remaining numerical digits within the scanline, the path decoder decoding multiple numerical digits in groups; and providing decoded numerical digits as an identifier represented by the scanline. Of course, other combinations and claims are described within the present disclosure.

Abstract: A waste stream is analyzed and sorted to segregate different items for recycling. Certain features of the technology improve the accuracy with which waste stream items are diverted to collection repositories. Other features concern adaptation of neural networks in accordance with context information sensed from the waste. Still other features serve to automate and simplify maintenance of machine vision systems used in waste sorting. Yet other aspects of the technology concern marking 2D machine readable code data on items having complex surfaces (e.g., food containers with integral ribbing for structural strength or juice pooling), to mitigate issues that such surfaces can introduce in code reading. Still other aspects of the technology concern prioritizing certain blocks of conveyor belt imagery for analysis. Yet other aspects of the technology concern joint use of near infrared spectroscopy, artificial intelligence, digital watermarking, and/or other techniques, for waste sorting.

Abstract: Audio signal processing enhances audio watermark embedding and detecting processes. Audio signal processes include audio classification and adapting watermark embedding and detecting based on classification. Advances in audio watermark design include adaptive watermark signal structure data protocols, perceptual models, and insertion methods. Perceptual and robustness evaluation is integrated into audio watermark embedding to optimize audio quality relative the original signal, and to optimize robustness or data capacity. These methods are applied to audio segments in audio embedder and detector configurations to support real time operation. Feature extraction and matching are also used to adapt audio watermark embedding and detecting.

Abstract: Compounds of Formula I: pharmaceutically acceptable salts thereof, deuterated derivatives of any of the foregoing, and metabolites of any of the foregoing are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed.

Abstract: Technology for constructing a symbol template for use by a 1D barcode decoder. One method includes obtaining a first symbol pattern representing a first symbol, the first symbol pattern comprising a plurality of elements, with each element corresponding to a 1D barcode space or bar, in which the first symbol represents one unique 1D bar (b) and space (s) pattern corresponding to a symbol or digit: 0, 1, 2, 3, 4, 5, 6, 7, 8 or 9; obtaining prefix elements, the prefix elements comprising a subset of second symbol elements from a second symbol pattern which precedes the first symbol from within a scanline of image data, the subset being less than a total number of elements within the second symbol elements; extending the first symbol pattern with the prefix elements to yield an overlapping symbol template for use in correlation-based barcode decoding. Other technology provided as well.

Abstract: The parameters of an optical code are optimized to achieve improved signal robustness, reliability, capacity and/or visual quality. An optimization program can determine spatial density, dot distance, dot size and signal component priority to optimize robustness. An optical code generator employs these parameters to produce an optical code at the desired spatial density and robustness. The optical code is merged into a host image, such as imagery, text and graphics of a package or label, or it may be printed by itself, e.g., on an otherwise blank label or carton. A great number of other features and arrangements are also detailed.

Abstract: Compounds of Formula I: pharmaceutically acceptable salts thereof, deuterated derivatives of any of the foregoing, and metabolites of any of the foregoing are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed.