Patents by Inventor Brett Buno

Brett Buno has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for purification of a virus produced in vitro and clearance assay for the virus
    Patent number: 10336988
    Abstract: A method of purification of non-enveloped or pseudo-enveloped virus produced in vitro uses a composition with at least one detergent. A method of purification can use multiple detergents, and a method of determining the presence and/or level of a non-enveloped or pseudo-enveloped virus in a sample includes treating with at least one detergent.
    Type: Grant
    Filed: July 19, 2016
    Date of Patent: July 2, 2019
    Assignee: GRIFOLS, S.A.
    Inventors: Brett Buno, Terri Journigan, Joann Hotta, Michael Burdick
  • Method for generating high-titer hepatitis E virus stocks and titration assay for hepatitis E virus
    Patent number: 10208291
    Abstract: Polybrene as an additive in cell culture medium is used in methods for the generation of high-titer hepatitis E virus stocks and assays for titration of hepatitis E virus. A cell culture medium containing polybrene is used for high-titer HEV generation, a method for determining the presence and/or the level of HEV in a sample, and an HEV titration assay using polybrene.
    Type: Grant
    Filed: July 19, 2016
    Date of Patent: February 19, 2019
    Assignee: GRIFOLS, S.A.
    Inventors: Brett Buno, Terri Journigan, Joann Hotta, Michael Burdick
  • Human erythrovirus
    Patent number: 9598739
    Abstract: Nucleic acid molecules derived from sequences of novel human parvovirus B19 variant genomes are provided. Also provided are assays and kits comprising the nucleic acid molecules.
    Type: Grant
    Filed: May 28, 2014
    Date of Patent: March 21, 2017
    Assignee: Grifols Therapeutics Inc.
    Inventors: Danuta Wronska, Brett Buno
  • METHODS FOR PURIFICATION OF A VIRUS PRODUCED IN VITRO AND CLEARANCE ASSAY FOR THE VIRUS
    Publication number: 20170022480
    Abstract: A method of purification of non-enveloped or pseudo-enveloped virus produced in vitro uses a composition with at least one detergent. A method of purification can use multiple detergents, and a method of determining the presence and/or level of a non-enveloped or pseudo-enveloped virus in a sample includes treating with at least one detergent.
    Type: Application
    Filed: July 19, 2016
    Publication date: January 26, 2017
    Inventors: BRETT BUNO, TERRI JOURNIGAN, JOANN HOTTA, MICHAEL BURDICK
  • METHOD FOR GENERATING HIGH-TITER HEPATITIS E VIRUS STOCKS AND TITRATION ASSAY FOR HEPATITIS E VIRUS
    Publication number: 20170022481
    Abstract: Polybrene as an additive in cell culture medium is used in methods for the generation of high-titer hepatitis E virus stocks and assays for titration of hepatitis E virus. A cell culture medium containing polybrene is used for high-titer HEV generation, a method for determining the presence and/or the level of HEV in a sample, and an HEV titration assay using polybrene.
    Type: Application
    Filed: July 19, 2016
    Publication date: January 26, 2017
    Inventors: BRETT BUNO, TERRI JOURNIGAN, JOANN HOTTA, MICHAEL BURDICK
  • Methods for detection of parvovirus B19
    Patent number: 9290820
    Abstract: Nucleic acid molecules derived from sequences of novel human parvovirus B19 variant genomes are provided. Also provided are assays and kits comprising the nucleic acid molecules.
    Type: Grant
    Filed: October 14, 2013
    Date of Patent: March 22, 2016
    Assignee: Grifols Therapeutics Inc.
    Inventors: Douglas C. Lee, Todd M. Gierman, Chris Glenn, Burton Beams, Brett Buno, Lori Rinckel
  • METHODS, COMPOSITIONS, AND KITS FOR DETERMINING HEPATITUS A VIRUS
    Publication number: 20140193803
    Abstract: The present invention relates to compositions, methods, and kits for determining the presence or absence of HAV in a sample.
    Type: Application
    Filed: August 1, 2012
    Publication date: July 10, 2014
    Applicant: GRIFOLS THERAPEUTICS INC.
    Inventors: Danuta Wronska, Brett Buno, Stefan Burde
  • METHODS, NUCLEIC ACIDS, AND KITS FOR DETECTION OF PARVOVIRUS B19
    Publication number: 20140106337
    Abstract: Nucleic acid molecules derived from sequences of novel human parvovirus B19 variant genomes are provided. Also provided are assays and kits comprising the nucleic acid molecules.
    Type: Application
    Filed: October 14, 2013
    Publication date: April 17, 2014
    Applicant: GRIFOLS THERAPEUTICS INC.
    Inventors: DOUGLAS C. LEE, TODD M. GIERMAN, CHRIS GLENN, BURTON BEAMS, BRETT BUNO, LORI RINCKEL
  • HUMAN ERYTHROVIRUS
    Publication number: 20100196875
    Abstract: Nucleic acid molecules derived from sequences of novel human parvovirus B19 variant genomes are provided. Also provided are assays and kits comprising the nucleic acid molecules.
    Type: Application
    Filed: January 15, 2008
    Publication date: August 5, 2010
    Applicant: Talecris Biotherapeutics, Inc.
    Inventors: Douglas C. Lee, Todd M. Gieman, Chris Glenn, Burton Beams, Brett Buno, Lori Rinckel