Abstract: Provided herein are oral dosage forms comprising a) a core tablet comprising (i) a drug layer comprising apremilast and hypromellose acetate succinate (HPMCAS) in an amorphous solid dispersion; and (ii) a swellable layer comprising one or more swellable polymers; and b) a coating layer disposed on the core tablet, wherein the oral dosage form surface comprises at least one drug release orifice. The disclosed oral dosage forms provide once-a-day dosing of apremilast and are suitable for treating diseases or disorders ameliorated by inhibiting phosphodiesterase subtype IV (PDE4).

Abstract: Provided herein are oral dosage forms comprising a) a core tablet comprising (i) a drug layer comprising apremilast and hypromellose acetate succinate (HPMCAS) in an amorphous solid dispersion; and (ii) a swellable layer comprising one or more swellable polymers; and b) a coating layer disposed on the core tablet, wherein the oral dosage form surface comprises at least one drug release orifice. The disclosed oral dosage forms provide once-a-day dosing of apremilast and are suitable for treating diseases or disorders ameliorated by inhibiting phosphodiesterase subtype IV (PDE4).

Abstract: Provided herein are oral dosage forms comprising a) a core tablet comprising (i) a drug layer comprising apremilast and hypromellose acetate succinate (HPMCAS) in an amorphous solid dispersion; and (ii) a swellable layer comprising one or more swellable polymers; and b) a coating layer disposed on the core tablet, wherein the oral dosage form surface comprises at least one drug release orifice. The disclosed oral dosage forms provide once-a-day dosing of apremilast and are suitable for treating diseases or disorders ameliorated by inhibiting phosphodiesterase subtype IV (PDE4).

Abstract: Provided herein are oral dosage forms comprising a) a core tablet comprising (i) a drug layer comprising apremilast and hypromellose acetate succinate (HPMCAS) in an amorphous solid dispersion; and (ii) a swellable layer comprising one or more swellable polymers; and b) a coating layer disposed on the core tablet, wherein the oral dosage form surface comprises at least one drug release orifice. The disclosed oral dosage forms provide once-a-day dosing of apremilast and are suitable for treating diseases or disorders ameliorated by inhibiting phosphodiesterase subtype IV (PDE4).

Abstract: A node configured to emulate a hardware UP Maintenance End Point (MEP) using one or more DOWN MEPs includes a plurality of ports; a switching fabric configured to switch data between the plurality of ports; and processing circuitry communicatively coupled to the plurality of ports and configured to emulate an UP MEP on a first port of the plurality of ports using at least a first DOWN MEP on a second port of the plurality of ports. The DOWN MEP can be implemented in hardware on the second port and the processing circuitry can be configured to execute application software configured to emulate the UP MEP.

Abstract: Provided are certain pharmaceutical formulations of omecamtiv mecarbil and methods for their preparation and use.

Abstract: A method and system are provided for controlling the operating temperature of a torque converter during torque converter stall conditions. The torque converter has a pump rotatably driven by an internal combustion engine and a rotatable turbine fluidly coupled to the pump. The system first determines whether the torque converter is currently in a torque converter stall condition, and, if so, determines a slip speed as a difference in rotational speeds between the pump and the turbine, determines an engine output torque limit as a function of the slip speed and a desired slip speed, and controls the operating temperature of the torque converter by limiting output torque produced by the engine based on the engine output torque limit.

Abstract: A node configured to emulate a hardware UP Maintenance End Point (MEP) using one or more DOWN MEPs includes a plurality of ports; a switching fabric configured to switch data between the plurality of ports; and processing circuitry communicatively coupled to the plurality of ports and configured to emulate an UP MEP on a first port of the plurality of ports using at least a first DOWN MEP on a second port of the plurality of ports. The DOWN MEP can be implemented in hardware on the second port and the processing circuitry can be configured to execute application software configured to emulate the UP MEP.

Abstract: A method and system are provided for controlling overspeeding of a vehicle carrying an internal combustion engine having one or more exhaust brake devices controllable to apply braking torque to the engine. The system may be operable determine a desired speed of the vehicle, to determine a road speed of the vehicle, and if the road speed of the vehicle exceeds the desired speed of the vehicle by more than a threshold speed, to determine a target brake torque required to reduce the road speed of the vehicle speed to the desired speed of the vehicle, and to then control the one or more exhaust brake devices to apply the target brake torque to the engine to thereby control the road speed of the vehicle to the desired speed of the vehicle.

Abstract: Provided are certain pharmaceutical formulations of omecamtiv mecarbil and methods for their preparation and use.

Abstract: A method and system are provided for controlling the operating temperature of a torque converter during torque converter stall conditions. The torque converter has a pump rotatably driven by an internal combustion engine and a rotatable turbine fluidly coupled to the pump. The system first determines whether the torque converter is currently in a torque converter stall condition, and, if so, determines a slip speed as a difference in rotational speeds between the pump and the turbine, determines an engine output torque limit as a function of the slip speed and a desired slip speed, and controls the operating temperature of the torque converter by limiting output torque produced by the engine based on the engine output torque limit.

Abstract: The present disclosure provides protection systems and methods that provide a mechanism to identify/determine when an interconnection node has been isolated (i.e. when there is no connectivity between a pair of interconnection nodes), from a data path perspective. If/when this condition exists, actions are triggered on the subtending sub-ring that essentially perform a protection switch (which causes the subtending sub-ring nodes to cleanse their forwarding tables), and, more importantly, that remove any channel blocks on the subtending sub-ring. Extensions to the ITU-T G.8032 state machine are also provided that include support for operator command interactions (e.g. DNR, force switch, manual switch, etc.). The protection systems and methods of the present disclosure enable the reliable application of ITU-T G.8032 and the like to more complex (i.e. meshed) deployment environments, among other significant advantages.

Abstract: A method and system are provided for controlling overspeeding of a vehicle carrying an internal combustion engine having one or more exhaust brake devices controllable to apply braking torque to the engine. The system may be operable determine a desired speed of the vehicle, to determine a road speed of the vehicle, and if the road speed of the vehicle exceeds the desired speed of the vehicle by more than a threshold speed, to determine a target brake torque required to reduce the road speed of the vehicle speed to the desired speed of the vehicle, and to then control the one or more exhaust brake devices to apply the target brake torque to the engine to thereby control the road speed of the vehicle to the desired speed of the vehicle.

Abstract: A method and system are provided for controlling overspeeding of a vehicle carrying an internal combustion engine having one or more exhaust brake devices controllable to apply braking torque to the engine. The system may be operable determine a desired speed of the vehicle, to determine a road speed of the vehicle, and if the road speed of the vehicle exceeds the desired speed of the vehicle by more than a threshold speed, to determine a target brake torque required to reduce the road speed of the vehicle speed to the desired speed of the vehicle, and to then control the one or more exhaust brake devices to apply the target brake torque to the engine to thereby control the road speed of the vehicle to the desired speed of the vehicle.

Abstract: A method and system are provided for controlling the operating temperature of a torque converter during torque converter stall conditions. The torque converter has a pump rotatably driven by an internal combustion engine and a rotatable turbine fluidly coupled to the pump. The system first determines whether the torque converter is currently in a torque converter stall condition, and, if so, determines a slip speed as a difference in rotational speeds between the pump and the turbine, determines an engine output torque limit as a function of the slip speed and a desired slip speed, and controls the operating temperature of the torque converter by limiting output torque produced by the engine based on the engine output torque limit.

Abstract: The present disclosure provides protection systems and methods that provide a mechanism to identify/determine when an interconnection node has been isolated (i.e. when there is no connectivity between a pair of interconnection nodes), from a data path perspective. If/when this condition exists, actions are triggered on the subtending sub-ring that essentially perform a protection switch (which causes the subtending sub-ring nodes to cleanse their forwarding tables), and, more importantly, that remove any channel blocks on the subtending sub-ring. Extensions to the ITU-T G.8032 state machine are also provided that include support for operator command interactions (e.g. DNR, force switch, manual switch, etc.). The protection systems and methods of the present disclosure enable the reliable application of ITU-T G.8032 and the like to more complex (i.e. meshed) deployment environments, among other significant advantages.

Abstract: A method and system are provided for controlling the operating temperature of a torque converter during torque converter stall conditions. The torque converter has a pump rotatably driven by an internal combustion engine and a rotatable turbine fluidly coupled to the pump. The system first determines whether the torque converter is currently in a torque converter stall condition, and, if so, determines a slip speed as a difference in rotational speeds between the pump and the turbine, determines an engine output torque limit as a function of the slip speed and a desired slip speed, and controls the operating temperature of the torque converter by limiting output torque produced by the engine based on the engine output torque limit.

Abstract: A method and system are provided for controlling the operating temperature of a torque converter during torque converter stall conditions. The torque converter has a pump rotatably driven by an internal combustion engine and a rotatable turbine fluidly coupled to the pump. The system first determines whether the torque converter is currently in a torque converter stall condition, and, if so, determines a slip speed as a difference in rotational speeds between the pump and the turbine, determines an engine output torque limit as a function of the slip speed and a desired slip speed, and controls the operating temperature of the torque converter by limiting output torque produced by the engine based on the engine output torque limit.

Abstract: A method and system are provided for controlling the operating temperature of a torque converter during torque converter stall conditions. The torque converter has a pump rotatably driven by an internal combustion engine and a rotatable turbine fluidly coupled to the pump. The system first determines whether the torque converter is currently in a torque converter stall condition, and, if so, determines a slip speed as a difference in rotational speeds between the pump and the turbine, determines an engine output torque limit as a function of the slip speed and a desired slip speed, and controls the operating temperature of the torque converter by limiting output torque produced by the engine based on the engine output torque limit.

Abstract: A method and system are provided for controlling the operating temperature of a torque converter during torque converter stall conditions. The torque converter has a pump rotatably driven by an internal combustion engine and a rotatable turbine fluidly coupled to the pump. The system first determines whether the torque converter is currently in a torque converter stall condition, and, if so, determines a slip speed as a difference in rotational speeds between the pump and the turbine, determines an engine output torque limit as a function of the slip speed and a desired slip speed, and controls the operating temperature of the torque converter by limiting output torque produced by the engine based on the engine output torque limit.