Patents by Inventor Brett Chevalier

Brett Chevalier has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • WNT PATHWAY STIMULATION IN REPROGRAMMING SOMATIC CELLS WITH NUCLEAR REPROGRAMMING FACTORS
    Publication number: 20230279359
    Abstract: The invention provides compositions and methods of use in reprogramming somatic cells. Compositions and methods of the invention are of use, e.g., for generating or modulating (e.g., enhancing) generation of induced pluripotent stem cells by reprogramming somatic cells. The reprogrammed somatic cells are useful for a number of purposes, including treating or preventing a medical condition in an individual. The invention further provides methods for identifying an agent that reprograms somatic cells to a pluripotent state and/or enhances the speed and/or efficiency of reprogramming. Certain of the compositions and methods relate to modulating the Wnt pathway.
    Type: Application
    Filed: December 30, 2022
    Publication date: September 7, 2023
    Inventors: Brett Chevalier, Alexander Marson, Richard A. Young, Ruth Foreman, Rudolf Jaenisch
  • COMPOSITIONS FOR INCREASING HALF-LIFE OF A THERAPEUTIC AGENT IN CANINES AND METHODS OF USE
    Publication number: 20230279118
    Abstract: Provided are compositions for increasing the half-life of a polypeptide or polypeptides in a canine and methods of their use. The compositions involve variant canine IgG Fc regions.
    Type: Application
    Filed: December 5, 2022
    Publication date: September 7, 2023
    Inventors: William BRONDYK, Brett CHEVALIER, Juergen HORN, Madhusudan NATARAJAN
  • Compositions for increasing half-life of a therapeutic agent in felines and methods of use
    Patent number: 11739135
    Abstract: Provided are compositions for increasing the half-life of a polypeptide or polypeptides in a feline and methods of their use. The compositions involve variant feline IgG Fc regions.
    Type: Grant
    Filed: April 29, 2022
    Date of Patent: August 29, 2023
    Assignee: Invetx, Inc.
    Inventors: William Brondyk, Brett Chevalier, Juergen Horn, Madhusudan Natarajan
  • COMPOSITIONS FOR INCREASING HALF-LIFE OF A THERAPEUTIC AGENT IN CANINES AND METHODS OF USE
    Publication number: 20230127241
    Abstract: Provided are compositions for increasing the half-life of a polypeptide or polypeptides in a canine and methods of their use. The compositions involve variant canine IgG Fc regions.
    Type: Application
    Filed: July 28, 2022
    Publication date: April 27, 2023
    Inventors: William BRONDYK, Brett CHEVALIER, Juergen HORN, Madhusudan NATARAJAN
  • COMPOSITIONS FOR INCREASING HALF-LIFE OF A THERAPEUTIC AGENT IN FELINES AND METHODS OF USE
    Publication number: 20230090405
    Abstract: Provided are compositions for increasing the half-life of a polypeptide or polypeptides in a feline and methods of their use. The compositions involve variant feline IgG Fc regions.
    Type: Application
    Filed: October 12, 2022
    Publication date: March 23, 2023
    Inventors: William BRONDYK, Brett CHEVALIER, Juergen HORN, Madhusudan NATARAJAN
  • Compositions for increasing half-life of a therapeutic agent in canines and methods of use
    Patent number: 11548949
    Abstract: Provided are compositions for increasing the half-life of a polypeptide or polypeptides in a canine and methods of their use. The compositions involve variant canine IgG Fc regions.
    Type: Grant
    Filed: April 28, 2020
    Date of Patent: January 10, 2023
    Assignee: Invetx, Inc.
    Inventors: William Brondyk, Brett Chevalier, Juergen Horn, Madhusudan Natarajan
  • Compositions for increasing half-life of a therapeutic agent in canines and methods of use
    Patent number: 11542333
    Abstract: Provided are compositions for increasing the half-life of a polypeptide or polypeptides in a canine and methods of their use. The compositions involve variant canine IgG Fc regions.
    Type: Grant
    Filed: January 2, 2020
    Date of Patent: January 3, 2023
    Assignee: Invetx, Inc.
    Inventors: William Brondyk, Brett Chevalier, Juergen Horn, Madhusudan Natarajan
  • Compositions for increasing half-life of a therapeutic agent in felines and methods of use
    Patent number: 11498953
    Abstract: Provided are compositions for increasing the half-life of a polypeptide or polypeptides in a feline and methods of their use. The compositions involve variant feline IgG Fc regions.
    Type: Grant
    Filed: June 23, 2021
    Date of Patent: November 15, 2022
    Assignee: Invetx, Inc.
    Inventors: William Brondyk, Brett Chevalier, Juergen Horn, Madhusudan Natarajan
  • Polypeptides with altered binding to neonatal Fc receptor (FcRn) and methods of use
    Patent number: 11434276
    Abstract: Provided are compositions for increasing the half-life of a polypeptide or polypeptides in a canine and methods of their use. The compositions involve variant canine IgG Fc regions.
    Type: Grant
    Filed: May 11, 2021
    Date of Patent: September 6, 2022
    Assignee: Invetx, Inc.
    Inventors: William Brondyk, Brett Chevalier, Juergen Horn, Madhusudan Natarajan
  • COMPOSITIONS FOR INCREASING HALF-LIFE OF A THERAPEUTIC AGENT IN FELINES AND METHODS OF USE
    Publication number: 20220259282
    Abstract: Provided are compositions for increasing the half-life of a polypeptide or polypeptides in a feline and methods of their use. The compositions involve variant feline IgG Fc regions.
    Type: Application
    Filed: April 29, 2022
    Publication date: August 18, 2022
    Inventors: William Brondyk, Brett Chevalier, Juergen Horn, Madhusudan Natarajan
  • COMPOSITIONS FOR INCREASING HALF-LIFE OF A THERAPEUTIC AGENT IN FELINES AND METHODS OF USE
    Publication number: 20220009994
    Abstract: Provided are compositions for increasing the half-life of a polypeptide or polypeptides in a feline and methods of their use. The compositions involve variant feline IgG Fc regions.
    Type: Application
    Filed: June 23, 2021
    Publication date: January 13, 2022
    Inventors: William Brondyk, Brett Chevalier, Juergen Horn, Madhusudan Natarajan
  • COMPOSITIONS FOR INCREASING HALF-LIFE OF A THERAPEUTIC AGENT IN CANINES AND METHODS OF USE
    Publication number: 20210347854
    Abstract: Provided are compositions for increasing the half-life of a polypeptide or polypeptides in a canine and methods of their use. The compositions involve variant canine IgG Fc regions.
    Type: Application
    Filed: May 11, 2021
    Publication date: November 11, 2021
    Inventors: William Brondyk, Brett Chevalier, Juergen Horn, Madhusudan Natarajan
  • IDENTIFICATION AND TARGETED MODULATION OF GENE SIGNALING NETWORKS
    Publication number: 20210254056
    Abstract: The present invention provides methods and compositions for the evaluation, alteration and/or optimization of gene signaling. Methods and systems are also provided which exploit the information generated in the identification of new targets and non-canonical signaling pathways.
    Type: Application
    Filed: May 4, 2018
    Publication date: August 19, 2021
    Inventors: Yuting LIU, Alla SIGOVA, Charles W. O'DONNELL, Cynthia SMITH, Gavin WHISSELL, Brett CHEVALIER, Jennifer F. BRYAN, Donna T. WARD
  • COMPOSITIONS FOR INCREASING HALF-LIFE OF A THERAPEUTIC AGENT IN CANINES AND METHODS OF USE
    Publication number: 20200362035
    Abstract: Provided are compositions for increasing the half-life of a polypeptide or polypeptides in a canine and methods of their use. The compositions involve variant canine IgG Fc regions.
    Type: Application
    Filed: April 28, 2020
    Publication date: November 19, 2020
    Inventors: William Brondyk, Brett Chevalier, Juergen Horn, Madhusudan Natarajan
  • COMPOSITIONS FOR INCREASING HALF-LIFE OF A THERAPEUTIC AGENT IN CANINES AND METHODS OF USE
    Publication number: 20200216536
    Abstract: Provided are compositions for increasing the half-life of a polypeptide or polypeptides in a canine and methods of their use. The compositions involve variant canine IgG Fc regions.
    Type: Application
    Filed: January 2, 2020
    Publication date: July 9, 2020
    Inventors: William Brondyk, Brett Chevalier, Juergen Horn, Madhusudan Natarajan
  • WNT PATHWAY STIMULATION IN REPROGRAMMING SOMATIC CELLS WITH NUCLEAR REPROGRAMMING FACTORS
    Publication number: 20190284537
    Abstract: The invention provides compositions and methods of use in reprogramming somatic cells. Compositions and methods of the invention are of use, e.g., for generating or modulating (e.g., enhancing) generation of induced pluripotent stem cells by reprogramming somatic cells. The reprogrammed somatic cells are useful for a number of purposes, including treating or preventing a medical condition in an individual. The invention further provides methods for identifying an agent that reprograms somatic cells to a pluripotent state and/or enhances the speed and/or efficiency of reprogramming. Certain of the compositions and methods relate to modulating the Wnt pathway.
    Type: Application
    Filed: February 19, 2019
    Publication date: September 19, 2019
    Inventors: Brett Chevalier, Alexander Marson, Richard A. Young, Ruth Foreman, Rudolf Jaenisch
  • WNT PATHWAY STIMULATION IN REPROGRAMMING SOMATIC CELLS WITH NUCLEAR REPROGRAMMING FACTORS
    Publication number: 20170218341
    Abstract: The invention provides compositions and methods of use in reprogramming somatic cells. Compositions and methods of the invention are of use, e.g., for generating or modulating (e.g., enhancing) generation of induced pluripotent stem cells by reprogramming somatic cells. The reprogrammed somatic cells are useful for a number of purposes, including treating or preventing a medical condition in an individual. The invention further provides methods for identifying an agent that reprograms somatic cells to a pluripotent state and/or enhances the speed and/or efficiency of reprogramming. Certain of the compositions and methods relate to modulating the Wnt pathway.
    Type: Application
    Filed: February 9, 2017
    Publication date: August 3, 2017
    Inventors: Brett Chevalier, Alexander Marson, Richard A. Young, Ruth Foreman, Rudolf Jaenisch
  • Wnt pathway stimulation in reprogramming somatic cells with nuclear reprogramming factors
    Patent number: 9593311
    Abstract: The invention provides compositions and methods of use in reprogramming somatic cells. Compositions and methods of the invention are of use, e.g., for generating or modulating (e.g., enhancing) generation of induced pluripotent stem cells by reprogramming somatic cells. The reprogrammed somatic cells are useful for a number of purposes, including treating or preventing a medical condition in an individual. The invention further provides methods for identifying an agent that reprograms somatic cells to a pluripotent state and/or enhances the speed and/or efficiency of reprogramming. Certain of the compositions and methods relate to modulating the Wnt pathway.
    Type: Grant
    Filed: August 10, 2015
    Date of Patent: March 14, 2017
    Assignee: Whitehead Institute for Biomedical Research
    Inventors: Brett Chevalier, Alexander Marson, Richard A. Young, Ruth Foreman, Rudolf Jaenisch
  • WNT PATHWAY STIMULATION IN REPROGRAMMING SOMATIC CELLS WITH NUCLEAR REPROGRAMMING FACTORS
    Publication number: 20160068819
    Abstract: The invention provides compositions and methods of use in reprogramming somatic cells. Compositions and methods of the invention are of use, e.g., for generating or modulating (e.g., enhancing) generation of induced pluripotent stem cells by reprogramming somatic cells. The reprogrammed somatic cells are useful for a number of purposes, including treating or preventing a medical condition in an individual. The invention further provides methods for identifying an agent that reprograms somatic cells to a pluripotent state and/or enhances the speed and/or efficiency of reprogramming. Certain of the compositions and methods relate to modulating the Wnt pathway.
    Type: Application
    Filed: August 10, 2015
    Publication date: March 10, 2016
    Inventors: Brett Chevalier, Alexander Marson, Richard A. Young, Ruth Foreman, Rudolf Jaenisch
  • Wnt pathway stimulation in reprogramming somatic cells with nuclear reprogramming factors
    Patent number: RE49281
    Abstract: The invention provides compositions and methods of use in reprogramming somatic cells. Compositions and methods of the invention are of use, e.g., for generating or modulating (e.g., enhancing) generation of induced pluripotent stem cells by reprogramming somatic cells. The reprogrammed somatic cells are useful for a number of purposes, including treating or preventing a medical condition in an individual. The invention further provides methods for identifying an agent that reprograms somatic cells to a pluripotent state and/or enhances the speed and/or efficiency of reprogramming. Certain of the compositions and methods relate to modulating the Wnt pathway.
    Type: Grant
    Filed: December 13, 2019
    Date of Patent: November 8, 2022
    Assignee: Whitehead Institute for Biomedical Research
    Inventors: Brett Chevalier, Alexander Marson, Richard A. Young, Ruth Foreman, Rudolf Jaenisch