Patents by Inventor Brett D. Allison

Brett D. Allison has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • P2X7 modulators and methods of use
    Patent number: 10112937
    Abstract: The present invention is directed to compounds of Formulas (I, Ia, IIa and IIb). The invention also relates to pharmaceutical compositions comprising compounds of Formulas (I, Ia, IIa and IIb). Methods of making and using the compounds of Formulas (I, Ia, IIa and IIb) are also within the scope of the invention.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: October 30, 2018
    Assignee: Janssen Pharmaceutica NV
    Inventors: Manuel Jesus Alcazar Vaca, Brett D. Allison, Jose Ignacio Andres Gil, Christa C. Chrovian, Heather R. Coate, Meri De Angelis, Xiaohu Deng, Curt A. Dvorak, Christine F. Gelin, Michael A. Letavic, Jimmy T. Liang, Neelakandha S. Mani, Jason C. Rech, Brad M. Savall, Akinola Soyode-Johnson, Brice M. Stenne, Devin M. Swanson, Jessica L. Wall
  • Methods for preparation of quinazoline derivatives
    Patent number: 9988357
    Abstract: Methods for preparing compounds having the following structure (I): or a pharmaceutically acceptable salt, stereoisomer, or tautomer thereof, wherein R1, R2a, R2b, R3a, R3b, R4a, R4b and R4c, are as defined herein are provided. Related compounds and methods for making the same are also provided.
    Type: Grant
    Filed: December 9, 2016
    Date of Patent: June 5, 2018
    Assignee: Araxes Pharma LLC
    Inventors: Neelakandha S. Mani, Brett D. Allison, Zachary S. Sales, Jimmy T. Liang, Xiaohu Deng, Liansheng Li, Yun Oliver Long, Yuan Liu, Pingda Ren
  • Tetrahydro-pyrimidoazepines as modulators of TRPV1
    Patent number: 9738649
    Abstract: Certain tetrahydro-pyrimidoazepine compounds are described, which are useful as TRPV1 modulators. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by TRPV1. Thus, the compounds may be administered to treat, e.g., pain, itch, cough, asthma, or inflammatory bowel disease.
    Type: Grant
    Filed: July 12, 2016
    Date of Patent: August 22, 2017
    Assignee: JANSSEN PHARMACEUTICA N.V.
    Inventors: Brett D. Allison, Bryan James Branstetter, J. Guy Breitenbucher, Michael D. Hack, Natalie A. Hawryluk, Alec D. Lebsack, Kelly J. McClure, Jeffrey E. Merit
  • METHODS FOR PREPARATION OF QUINAZOLINE DERIVATIVES
    Publication number: 20170190672
    Abstract: Methods for preparing compounds having the following structure (I): or a pharmaceutically acceptable salt, stereoisomer, or tautomer thereof, wherein R1, R2a, R2b, R3a, R3b, R4a, R4b and R4c, are as defined herein are provided. Related compounds and methods for making the same are also provided.
    Type: Application
    Filed: December 9, 2016
    Publication date: July 6, 2017
    Inventors: Neelakandha S. Mani, Brett D. Allison, Zachary S. Sales, Jimmy T. Liang, Xiaohu Deng, Liansheng Li, Yun Oliver Long, Yuan Liu, Pingda Ren
  • TETRAHYDRO-PYRIMIDOAZEPINES AS MODULATORS OF TRPV1
    Publication number: 20160318942
    Abstract: Certain tetrahydro-pyrimidoazepine compounds are described, which are useful as TRPV1 modulators. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by TRPV1. Thus, the compounds may be administered to treat, e.g., pain, itch, cough, asthma, or inflammatory bowel disease.
    Type: Application
    Filed: July 12, 2016
    Publication date: November 3, 2016
    Inventors: Brett D. Allison, Bryan James Branstetter, J. Guy Breitenbucher, Michael D. Hack, Natalie A. Hawryluk, Alec D. Lebsack, Kelly J. McClure, Jeffrey E. Merit
  • Tetrahydro-pyrimidoazepines as modulators of TRPV1
    Patent number: 9422293
    Abstract: Certain tetrahydro-pyrimidoazepine compounds are described, which are useful as TRPV1 modulators. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by TRPV1. Thus, the compounds may be administered to treat, e.g., pain, itch, cough, asthma, or inflammatory bowel disease.
    Type: Grant
    Filed: January 17, 2014
    Date of Patent: August 23, 2016
    Assignee: Janssen Pharmaceutica NV
    Inventors: Brett D. Allison, Bryan James Branstetter, J. Guy Breitenbucher, Michael D. Hack, Natalie A. Hawryluk, Alec D. Lebsack, Kelly J. McClure, Jeffrey E. Merit
  • P2X7 MODULATORS
    Publication number: 20160039809
    Abstract: The present invention is directed to compounds of Formulas (I, Ia, IIa and IIb). The invention also relates to pharmaceutical compositions comprising compounds of Formulas (I, Ia, IIa and IIb). Methods of making and using the compounds of Formulas (I, Ia, IIa and IIb) are also within the scope of the invention.
    Type: Application
    Filed: March 14, 2014
    Publication date: February 11, 2016
    Inventors: Manuel Jesus ALCAZAR VACA, Brett D. ALLISON, Jose Ignacio ANDRES GIL, Christa C. CHROVIAN, Heather R. COATE, Meri DE ANGELIS, Xiaohu DENG, Curt A. DVORAK, Christine F. GELIN, Michael A. LETAVIC, Jimmy T. LIANG, Neelakandha S. MANI, Jason C. RECH, Brad M. SAVALL, Akinola SOYODE-JOHNSON, Brice M. STENNE, Devin M. SWANSON, Jessica L. WALL
  • TETRAHYDRO-PYRIMIDOAZEPINES AS MODULATORS OF TRPV1
    Publication number: 20140135311
    Abstract: Certain tetrahydro-pyrimidoazepine compounds are described, which are useful as TRPV1 modulators. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by TRPV1. Thus, the compounds may be administered to treat, e.g., pain, itch, cough, asthma, or inflammatory bowel disease.
    Type: Application
    Filed: January 17, 2014
    Publication date: May 15, 2014
    Applicant: Janssen Pharmaceutica NV
    Inventors: Brett D. Allison, Bryan James Branstetter, J. Guy Breitenbucher, Michael D. Hack, Natalie A. Hawryluk, Alec D. Lebsack, Kelly J. McClure, Jeffrey E. Merit
  • Bicyclic pyrazole compounds as antibacterial agents
    Patent number: 8242275
    Abstract: Antibacterial compounds, compositions containing them, and methods of use for the inhibition of bacterial activity and the treatment, prevention or inhibition of bacterial infection.
    Type: Grant
    Filed: July 9, 2010
    Date of Patent: August 14, 2012
    Assignee: Janssen Pharmaceutica NV
    Inventors: Brett D. Allison, Laurent Gomez, Cheryl A. Grice, Michael D. Hack, Brian J. Morrow, S. Timothy Motley, Alejandro Santillan, Jr., Karen J. Shaw, Kimberly L. Schwarz, Liu Y. Tang, Hariharan Venkatesan, John J. M. Wiener
  • Bicyclic pyrazole compounds as antibacterial agents
    Patent number: 8232391
    Abstract: Antibacterial compounds, compositions containing them, and methods of use for the inhibition of bacterial activity and the treatment, prevention or inhibition of bacterial infection.
    Type: Grant
    Filed: July 9, 2010
    Date of Patent: July 31, 2012
    Assignee: Janssen Pharmaceutica NV
    Inventors: Brett D. Allison, Laurent Gomez, Cheryl A. Grice, Michael D. Hack, Brian J. Morrow, S. Timothy Motley, Alejandro Santillan, Jr., Karen J. Shaw, Kimberly L. Schwarz, Liu Y. Tang, Hariharan Venkatesan, John J. M. Wiener
  • INDOLE AND BENZOTHIOPHENE COMPOUNDS AS MODULATORS OF THE HISTAMINE H3 RECEPTOR
    Publication number: 20110178062
    Abstract: Certain substituted indole and benzothiophene compounds are histamine H3 receptor modulators useful in the treatment of histamine H3 receptor-mediated diseases.
    Type: Application
    Filed: February 28, 2008
    Publication date: July 21, 2011
    Inventors: Brett D. Allison, Cheryl A. Grice, Kelly J. McClure, Alejandro Santillan, JR.
  • Cyclopropyl amines as modulators of the histamine Hreceptor
    Patent number: 7910582
    Abstract: Certain cyclopropyl amines are histamine H3 modulators useful in the treatment of histamine H3 receptor mediated diseases.
    Type: Grant
    Filed: January 28, 2010
    Date of Patent: March 22, 2011
    Assignee: Janssen Pharmaceutica NV
    Inventors: Brett D. Allison, Cheryl A. Grice
  • Bicyclic pyrazole compounds as antibacterial agents
    Patent number: 7842810
    Abstract: Antibacterial compounds, compositions containing them, and methods of use for the inhibition of bacterial activity and the treatment, prevention or inhibition of bacterial infection.
    Type: Grant
    Filed: March 30, 2006
    Date of Patent: November 30, 2010
    Assignee: Janssen Pharmaceutica, NV
    Inventors: Brett D. Allison, Laurent Gomez, Cheryl A. Grice, Michael D. Hack, Alejandro Santillan, Jr., Kimberly L. Schwarz, Liu Y. Tang, Hariharan Venkatesan, John J. M. Wiener
  • BICYCLIC PYRAZOLE COMPOUNDS AS ANTIBACTERIAL AGENTS
    Publication number: 20100280240
    Abstract: Antibacterial compounds, compositions containing them, and methods of use for the inhibition of bacterial activity and the treatment, prevention or inhibition of bacterial infection.
    Type: Application
    Filed: July 9, 2010
    Publication date: November 4, 2010
    Inventors: Brett D. Allison, Laurent Gomez, Cheryl A. Grice, Michael D. Hack, Brain J. Morrow, S. Timothy Motley, Alejandro Santillan, JR., Karen J. Shaw, Kimberly L. Schwarz, Liu Y. Tang, Hariharan Venkatesan, John J.M. Wiener
  • BICYCLIC PIRAZOLE COMPOUNDS AS ANTIBACTERIAL AGENTS
    Publication number: 20100274004
    Abstract: Antibacterial compounds, compositions containing them, and methods of use for the inhibition of bacterial activity and the treatment, prevention or inhibition of bacterial infection.
    Type: Application
    Filed: July 9, 2010
    Publication date: October 28, 2010
    Inventors: Brett D. Allison, Laurent Gomez, Cheryl A. Grice, Michael D. Hack, Brian J. Morrow, S. Timothy Motley, Alejandro Santillan, JR., Karen J. Shaw, Kimberly L. Schwarz, Liu Y. Tang, Hariharan Venkatesan, John J.M. Wiener
  • BICYCLIC PYRAZOLE COMPOUNDS AS ANTIBACTERIAL AGENTS
    Publication number: 20100274005
    Abstract: Antibacterial compounds, compositions containing them, and methods of use for the inhibition of bacterial activity and the treatment, prevention or inhibition of bacterial infection.
    Type: Application
    Filed: July 9, 2010
    Publication date: October 28, 2010
    Inventors: Brett D. Allison, Laurent Gomez, Cheryl A. Grice, Michael D. Hack, Brian J. Morrow, S. Timothy Motley, Alejandro Santillan, JR., Karen J. Shaw, Kimberly L. Schwarz, Liu Y. Tang, Hariharan Venkatesan, John J. M. Wiener
  • Cyclopropyl Amines as Modulators of the Histamine H3 Receptor
    Publication number: 20100130485
    Abstract: Certain cyclopropyl amines are histamine H3 modulators useful in the treatment of histamine H3 receptor mediated diseases.
    Type: Application
    Filed: January 28, 2010
    Publication date: May 27, 2010
    Inventors: Brett D. Allison, Nicholas I. Carruthers, Cheryl A. Grice, Michael A. Letavic
  • Cyclopropyl amines as modulators of the histamine Hreceptor
    Patent number: 7687499
    Abstract: Certain cyclopropyl amines are histamine H3 modulators useful in the treatment of histamine H3 receptor mediated diseases.
    Type: Grant
    Filed: September 14, 2006
    Date of Patent: March 30, 2010
    Assignee: Janssen Pharmaceutica NV
    Inventors: Brett D. Allison, Nicholas I. Carruthers, Cheryl A. Grice, Michael A. Letavic
  • Quinoxaline compounds
    Patent number: 7563895
    Abstract: Certain amidophenyl-sulfonylamino-quinoxaline compounds are CCK2 modulators useful in the treatment of CCK2 mediated diseases.
    Type: Grant
    Filed: December 4, 2007
    Date of Patent: July 21, 2009
    Assignee: Janssen Pharmaceutica, N.V.
    Inventors: Brett D. Allison, Michael D. Hack, Victor K. Phuong, Michael H. Rabinowitz, Mark D. Rosen
  • SUBSTITUTED PYRAZINYL AMIDE COMPOUNDS AS MODULATORS OF THE HISTAMINE H3 RECEPTOR
    Publication number: 20090131416
    Abstract: Certain substituted pyrazinyl amide compounds are histamine H3 receptor modulators useful in the treatment of histamine H3 receptor-mediated diseases.
    Type: Application
    Filed: November 17, 2008
    Publication date: May 21, 2009
    Inventors: Brett D. Allison, Cheryl A. Grice, Michael A. Letavic