Patents by Inventor Brett Finlay
Brett Finlay has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20180333440Abstract: The present invention relates to bacterial compositions and methods of use thereof. The bacterial compositions may include two or more bacteria of the genera Faecalibacterium, Lachnospira, Veillonella or Rothia. The bacterial compositions may be used in treating gut dysbiosis, asthma, allergy, or atopy, or altering the gut microbiota, or populating the gastrointestinal tract, in a subject in need thereof.Type: ApplicationFiled: August 1, 2018Publication date: November 22, 2018Inventors: Brett FINLAY, Marie-Claire ARRIETA, Shannon RUSSELL, Stuart TURVEY, Leah STIEMSMA
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Publication number: 20180050070Abstract: The present invention relates to bacterial compositions and methods of use thereof. The bacterial compositions may include two or more bacteria of the genera Faecalibacterium, Lachnospira, Veillonella or Rothia. The bacterial compositions may be used in treating gut dysbiosis, asthma, allergy, or atopy, or altering the gut microbiota, or populating the gastrointestinal tract, in a subject in need thereof.Type: ApplicationFiled: March 11, 2016Publication date: February 22, 2018Inventors: Brett FINLAY, Marie-Claire Arrieta, Shannon RUSSELL, Stuart TURVEY, Leah STIEMSMA
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Patent number: 8758771Abstract: The invention relates to, in part, secreted proteins of bacterial pathogens and methods for their use. More specifically, the invention provides in part several new common secreted proteins for A/E pathogens. In some embodiments of the invention, these polypeptides and nucleic acid molecules encoding these polypeptides, or portions thereof, are useful as vaccines, diagnostics, or drug screening tools for A/E pathogenic infections, or as reagents.Type: GrantFiled: October 29, 2004Date of Patent: June 24, 2014Assignees: The University of British Columbia, Universidad Nacional Autonoma de MexicoInventors: Brett Finlay, Samantha Gruenheid, Wanyin Deng, Bruce A. Vallance, Jose L. Puente
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Publication number: 20140065188Abstract: Compositions and methods for stimulating an immune response against a secreted enterohemorragic Escherichia coli (EHEC) antigen are disclosed. The compositions comprise EHEC cell culture supernatants.Type: ApplicationFiled: November 12, 2013Publication date: March 6, 2014Applicants: University of Saskatchewan, The University of British ColumbiaInventors: B. Brett Finlay, Andrew A. Potter
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Patent number: 8586057Abstract: Compositions and methods for stimulating an immune response against a secreted enterohemorragic Escherichia coli (EHEC) antigen are disclosed. The compositions comprise EHEC cell culture supernatants.Type: GrantFiled: October 22, 2007Date of Patent: November 19, 2013Assignees: The University of British Columbia, University of SaskatchewanInventors: B. Brett Finlay, Andrew A. Potter
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Patent number: 8507249Abstract: The invention relates to, in part, secreted proteins of bacterial pathogens and methods for their use. More specifically, the invention provides in part several new common secreted proteins for A/E pathogens. In some embodiments of the invention, these polypeptides and nucleic acid molecules encoding these polypeptides, or portions thereof, are useful as vaccines, diagnostics, or drug screening tools for A/E pathogenic infections, or as reagents.Type: GrantFiled: July 13, 2011Date of Patent: August 13, 2013Assignees: Universidad Nacional Autonoma de Mexico, The University of British ColumbiaInventors: Brett Finlay, Samantha Gruenheid, Wanyin Deng, Bruce A. Vallance, Jose L. Puente
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Publication number: 20120064572Abstract: The invention relates to, in part, secreted proteins of bacterial pathogens and methods for their use. More specifically, the invention provides in part several new common secreted proteins for A/E pathogens. In some embodiments of the invention, these polypeptides and nucleic acid molecules encoding these polypeptides, or portions thereof, are useful as vaccines, diagnostics, or drug screening tools for A/E pathogenic infections, or as reagents.Type: ApplicationFiled: July 13, 2011Publication date: March 15, 2012Inventors: Brett Finlay, Samantha Gruenheid, Wanyin Deng, Bruce A. Vallance, Jose L. Puente
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Patent number: 8021861Abstract: The present invention provides a polypeptide, called EspA, which is secreted by pathogenic E. coli, such as the enteropathogenic (SPEC) and enterohemorrhagic (EHEC) E. coli. The invention also provides isolated nucleic acid sequences encoding EspA polypeptide, EspA peptides, a recombinant method for producing recombinant EspA, antibodies which bind to EspA, and a kit for the detection of EspA-producing E. coli.Type: GrantFiled: March 29, 2007Date of Patent: September 20, 2011Assignee: University of British ColumbiaInventors: B. Brett Finlay, Brendan Kenny, Markus Stein, Michael S. Donnenberg, Li-Ching Lai
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Publication number: 20110003339Abstract: The present invention provides a polypeptide, called EspA, which is secreted by pathogenic E. coli, such as the enteropathogenic (SPEC) and enterohemorrhagic (EHEC) E. coli. The invention also provides isolated nucleic acid sequences encoding EspA polypeptide, EspA peptides, a recombinant method for producing recombinant EspA, antibodies which bind to EspA, and a kit for the detection of EspA-producing E. coli.Type: ApplicationFiled: March 29, 2007Publication date: January 6, 2011Applicant: The University of British ColumbiaInventors: B. Brett Finlay, Brendan Kenny, Markus Stein, Michael S. Donnenberg, Li-Ching Lai
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Patent number: 7687454Abstract: A method of identifying a polynucleotide or pattern of polynucleotides regulated by one or more sepsis or inflammatory inducing agents and inhibited by a peptide is described. A method of identifying a pattern of polynucleotide expression for inhibition of an inflammatory or septic response. The method includes contacting cells with LPS, LTA, CpG DNA and/or intact microbe or microbial components in the presence or absence of a cationic peptide; detecting a pattern of polynucleotide expression for the cells in the presence and absence of the peptide, wherein the pattern in the presence of the peptide represents inhibition of an inflammatory or septic response. Also included are compounds and agents identified by the methods of the invention. In another aspect, the invention provides methods and compounds for enhancing innate immunity in a subject.Type: GrantFiled: September 12, 2003Date of Patent: March 30, 2010Assignee: The University of British ColumbiaInventors: Robert E. W. Hancock, B. Brett Finlay, Monisha Gough Scott, Dawn Bowdish, Carrie Melissa Rosenberger, Jon-Paul Steven Powers
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Patent number: 7507787Abstract: A method of identifying a polynucleotide or pattern of polynucleotides regulated by one or more sepsis or inflammatory inducing agents and inhibited by a peptide is described. A method of identifying a pattern of polynucleotide expression for inhibition of an inflammatory or septic response. The method includes contacting cells with LPS, LTA, CpG DNA and/or intact microbe or microbial components in the presence or absence of a cationic peptide; detecting a pattern of polynucleotide expression for the cells in the presence and absence of the peptide, wherein the pattern in the presence of the peptide represents inhibition of an inflammatory or septic response. Also included are compounds and agents identified by the methods of the invention. In another aspect, the invention provides methods and compounds for enhancing innate immunity in a subject.Type: GrantFiled: December 2, 2002Date of Patent: March 24, 2009Assignee: The University of British ColumbiaInventors: Robert E. W. Hancock, B. Brett Finlay, Monisha Gough Scott, Dawn Bowdish, Carrie Melissa Rosenberger, Jon-Paul Steven Powers
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Publication number: 20090068230Abstract: Compositions and methods for stimulating an immune response against a secreted enterohemorragic Escherichia coli (EHEC) antigen are disclosed. The compositions comprise EHEC cell culture supernatants.Type: ApplicationFiled: October 22, 2007Publication date: March 12, 2009Inventors: B. Brett Finlay, Andrew A. Potter
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Publication number: 20080145384Abstract: Compositions and methods for stimulating an immune response against a secreted enterohemorragic Escherichia coli (EHEC) antigen are disclosed. The compositions comprise EHEC cell culture supernatants.Type: ApplicationFiled: October 22, 2007Publication date: June 19, 2008Inventors: B. Brett Finlay, Andrew A. Potter
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Patent number: 7300659Abstract: Compositions and methods for stimulating an immune response against a secreted enterohemorragic Escherichia coli (EHEC) antigen are disclosed. The compositions comprise EHEC cell culture supernatants.Type: GrantFiled: January 3, 2002Date of Patent: November 27, 2007Assignees: University of Saskatchewan, University of British ColumbiaInventors: B. Brett Finlay, Andrew A. Potter
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Publication number: 20070218518Abstract: A polypeptide, called Tir (for translocated intimin receptor, which is secreted by attaching and effacing pathogens, such as the enteropathogenic (EPEC) and enterohemorrhagic (EHEC) E. coli. These bacterial pathogens inserts their own receptors into mammalian cell surfaces, to which the bacterial pathogen then adheres to trigger additional host signaling events and actin nucleation. Diagnosis of disease caused by pathogenic E. coli can be performed by the use of antibodies which bind to Tir to detect the protein or the use of nucleic acid probes for detection of nucleic acids encoding Tir polypeptide. Isolated nucleic acid sequences encoding Tir polypeptide, Tir peptides, a recombinant method for producing recombinant Tir, antibodies which bind to Tir, and a kit for the detection of Tir-producing E. coli are provided. A method of immunizing a host with Tir to induce a protective immune response to Tir or a second polypeptide of interest is also provided.Type: ApplicationFiled: November 9, 2006Publication date: September 20, 2007Applicant: The University of British ColumbiaInventors: Brett Finlay, Brendan Kenny, Rebekah DeVinney, Markus Stein
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Publication number: 20070213509Abstract: A polypeptide, called Tir (for translocated intimin receptor, which is secreted by attaching and effacing pathogens, such as the enteropathogenic (EPEC) and enterohemorrhagic (EHEC) E. coli. These bacterial pathogens inserts their own receptors into mammalian cell surfaces, to which the bacterial pathogen then adheres to trigger additional host signaling events and actin nucleation. Diagnosis of disease caused by pathogenic E. coli can be performed by the use of antibodies which bind to Tir to detect the protein or the use of nucleic acid probes for detection of nucleic acids encoding Tir polypeptide. Isolated nucleic acid sequences encoding Tir polypeptide, Tir peptides, a recombinant method for producing recombinant Tir, antibodies which bind to Tir, and a kit for the detection of Tir-producing E. coli are provided. A method of immunizing a host with Tir to induce a protective immune response to Tir or a second polypeptide of interst is also provided.Type: ApplicationFiled: November 9, 2006Publication date: September 13, 2007Applicant: The University of British ColumbiaInventors: Brett Finlay, Brendan Kenny, Rebekah DeVinney, Markus Stein
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Publication number: 20070184500Abstract: A polypeptide, called Tir (for translocated intimin receptor, which is secreted by attaching and effacing pathogens, such as the enteropathogenic (EPEC) and enterohemorrhagic (EHEC) E. coli. These bacterial pathogens inserts their own receptors into mammalian cell surfaces, to which the bacterial pathogen then adheres to trigger additional host signaling events and actin nucleation. Diagnosis of disease caused by pathogenic E. coli can be performed by the use of antibodies which bind to Tir to detect the protein or the use of nucleic acid probes for detection of nucleic acids encoding Tir polypeptide. Isolated nucleic acid sequences encoding Tir polypeptide, Tir peptides, a recombinant method for producing recombinant Tir, antibodies which bind to Tir, and a kit for the detection of Tir-producing E. coli are provided. A method of immunizing a host with Tir to induce a protective immune response to Tir or a second polypeptide of interest is also provided.Type: ApplicationFiled: November 9, 2006Publication date: August 9, 2007Applicant: The University of British ColumbiaInventors: Brett Finlay, Brendan Kenny, Rebekah DeVinney, Markus Stein
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Patent number: 7214499Abstract: The present invention provides a polypeptide, called EspA, which is secreted by pathogenic E. coli, such as the enteropathogenic (SPEC) and enterohemorrhagic (EHEC) E. coli. The invention also provides isolated nucleic acid sequences encoding EspA polypeptide, EspA peptides, a recombinant method for producing recombinant EspA, antibodies which bind to EspA, and a kit for the detection of EspA-producing E. coli.Type: GrantFiled: April 25, 2006Date of Patent: May 8, 2007Assignee: University of British ColumbiaInventors: B. Brett Finlay, Brendan Kenny, Markus Stein, Michael S. Donnenberg, Li-Ching Lai
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Patent number: 7208574Abstract: A polypeptide, called Tir (for translocated intimin receptor, which is secreted by attaching and effacing pathogens, such as the enteropathogenic (EPEC) and enterohemorrhagic (EHEC) E. coli. These bacterial pathogens inserts their own receptors into mammalian cell surfaces, to which the bacterial pathogen then adheres to trigger additional host signaling events and actin nucleation. Diagnosis of disease caused by pathogenic E. coli can be performed by the use of antibodies which bind to Tir to detect the protein or the use of nucleic acid probes for detection of nucleic acids encoding Tir polypeptide. Isolated nucleic acid sequences encoding Tir polypeptide, Tir peptides, a recombinant method for producing recombinant Tir, antibodies which bind to Tir, and a kit for the detection of Tir-producing E. coli are provided. A method of immunizing a host with Tir to induce a protective immune response to Tir or a second polypeptide of interest is also provided.Type: GrantFiled: November 10, 1998Date of Patent: April 24, 2007Assignee: The University of British ColumbiaInventors: B. Brett Finlay, Brendan Kenny, Rebekah DeVinney, Markus Stein
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Publication number: 20070041997Abstract: The invention relates to, in part, secreted proteins of bacterial pathogens and methods for their use. More specifically, the invention provides in part several new common secreted proteins for A/E pathogens. In some embodiments of the invention, these polypeptides and nucleic acid molecules encoding these polypeptides, or portions thereof, are useful as vaccines, diagnostics, or drug screening tools for A/E pathogenic infections, or as reagents.Type: ApplicationFiled: October 29, 2004Publication date: February 22, 2007Inventors: Brett Finlay, Samantha Gruenheid, Wanyin Deng, Bruce Vallance, Jose Puente