Abstract: The present disclosure describes an apparatus, method, system, and computer program product of detecting bubbles in images of a sample in wells of a well plate. In an exemplary embodiment, In an exemplary embodiment, the computer implemented method, the system, and the computer program product include receiving, by a computer system, at least one image of at least one well of a well plate containing a liquid sample, executing, by the computer system, a set of logical operations cropping the image to include a well of interest, and executing, by the computer system, a set of logical operations processing, by a trained convolutional neural network, the cropped image, resulting in a probability that the image depicts at least one bubble.

Abstract: The present disclosure describes a method, system, and computer program product of calculating electrophoretic mobility of a sample by extracting frequency shift. In an embodiment, the method, system, and computer program product include receiving at least one frequency domain spectrum relating to light intensity detector data corresponding to a sample, truncating the spectrum to a region of interest, establishing a minimum fitter amplitude for what constitutes a peak, identifying possible distinct peaks in the region of interest, finding initial parameters for fitting at least one distinct peak among the possible distinct peaks, selecting a selected fitting model from among a plurality of fitting models with respect to the possible distinct peaks, and fitting the at least one distinct peak to the selected fitting model resulting in at least one fitted signal peak corresponding to the light intensity detector data, allowing for calculating electrophoretic mobility of particles in the sample.

Abstract: The present disclosure describes an apparatus, method, system, and computer program product of detecting bubbles in images of a sample in wells of a well plate. In an exemplary embodiment, In an exemplary embodiment, the computer implemented method, the system, and the computer program product include receiving, by a computer system, at least one image of at least one well of a well plate containing a liquid sample, executing, by the computer system, a set of logical operations cropping the image to include a well of interest, and executing, by the computer system, a set of logical operations processing, by a trained convolutional neural network, the cropped image, resulting in a probability that the image depicts at least one bubble.

Abstract: Combinations of Bruton's tyrosine kinase (Btk) inhibitors, e.g., 1-((R)-3-(4-amino-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one, with a second anticancer agent are provided. Also provided are methods of treating cancers, and autoimmune disorders by administering combinations of Bruton's tyrosine kinase (Btk) inhibitors, e.g., 1-((R)-3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one, and second anticancer agents.

Abstract: Combinations of Bruton's tyrosine kinase (Btk) inhibitors, e.g., 1-((R)-3-(4-amino-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one, with a second anticancer agent are provided. Also provided are methods of treating cancers, and autoimmune disorders by administering combinations of Bruton's tyrosine kinase (Btk) inhibitors, e.g., 1-((R)-3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one, and second anticancer agents.