Abstract: A wearable infusion device comprises a reservoir that holds a liquid medicament, an outlet port that delivers the liquid medicament to a patient, a pump that displaces a volume of the liquid medicament to the outlet port when actuated, and a control that actuates the pump. The control comprises a snap action actuator.

Abstract: An infusion system comprises a disposable wearable infusion device having a body arranged to be adhered to a patient's skin and a reservoir for holding a liquid medicament to be infused into the patient through a cannula extending from the device body to beneath the patient's skin. The system further includes a cannula driver arranged to be detachably joined with the infusion device and including a cannula. The cannula driver is arranged to drive the cannula into a deployed position extending from the device body to beneath the patient's skin. The cannula driver includes a release mechanism that separates the cannula driver from the infusion device after the cannula is in the deployed position.

Abstract: Tissue fasteners carried on a tissue piercing deployment wire fasten tissue layers of a mammalian body together include a first member, a second member, and a connecting member extending between the first and second members. One of the first and second members has an elongated slot permitting fastener deployment while avoiding excessive tissue compression.

Abstract: Tissue fasteners carried on a tissue piercing deployment wire fasten tissue layers of a mammalian body together. The fasteners include a first member, a second member, and a connecting member extending between the first and second members. The first and second members are substantially parallel to each other. The fasteners may be deployed in limited spaces and in various applications including the restoration of a gastroesophageal flap valve.

Abstract: A tissue fastener assembly delivers a fastener for deployment. The assembly includes a fastener including a first member, a second member, the first and second members having first and second ends, and a flexible connecting member fixed to each of the first and second members intermediate the first and second ends and extending between the first and second members. The first member has a longitudinal axis and a through channel along the axis. The assembly further includes a deployment wire slidingly received within the through channel of the first member that pierces into the tissue and guides the first member through the tissue, a guide structure defining a lumen that receives the fastener and deployment wire and guides the deployment wire and fastener to the tissue, and a fastener configuration structure that orientates the second member in a predetermined position relative to the first member within the lumen for dependable deployment.

Abstract: A disposable wearable infusion device comprises a reservoir that holds a liquid medicament and a cannula having a distal end that delivers the liquid medicament to a patient The device further comprises a pump that displaces a volume of the liquid medicament along a path to the cannula when actuated and a lock-out that precludes actuation of the pump when an occlusion occurs within the path to the distal end of the cannula.

Abstract: A disposable wearable infusion device comprises a body arranged to be adhered to a patient's skin and to receive a cannula to extend from the infusion device to beneath the patient's skin, a reservoir for holding a liquid medicament to be infused into the patient, and a pump that displaces a volume of the liquid medicament from the reservoir to the cannula for delivery to the patient. The body has a port aligned with the cannula that permits the cannula to assume a deployed position to extend from the infusion device to beneath the patient's skin. The device further comprises a cover that blocks the port to preclude direct access to the cannula through the port after deployment.

Abstract: A wearable infusion device comprises a reservoir that holds a liquid medicament, an outlet port that delivers the liquid medicament to a patient, a pump that holds a volume of the liquid medicament received from the reservoir and displaces substantially all of the volume of the liquid medicament when actuated, and at least a first valve, a second valve, and a third valve. The valves establish fluid connection between the reservoir and the pump when in a first valve configuration and establish fluid connection between the pump and the outlet when in a second valve configuration. At least two of the valves isolate the outlet from the reservoir when the valves are in the first valve configuration.

Abstract: An infusion system comprises a disposable wearable infusion device having a body arranged to be adhered to a patient's skin and a reservoir for holding a liquid medicament to be infused into the patient through a cannula extending from the device body to beneath the patient's skin. The system further includes a cannula driver arranged to be detachably joined with the infusion device and including a cannula. The cannula driver is arranged to drive the cannula into a deployed position extending from the device body to beneath the patient's skin. The cannula driver includes a release mechanism that separates the cannula driver from the infusion device after the cannula is in the deployed position.

Abstract: Tissue fasteners carried on a tissue piercing deployment wire fasten tissue layers of a mammalian body together include a first member, a second member, and a connecting member extending between the first and second members. One of the first and second members has an elongated slot permitting fastener deployment while avoiding excessive tissue compression.

Abstract: A low profile wearable infusion device comprises a generally cylindrical reservoir having a diameter greater than its height and a drive that causes a piston to move an incremental distance within the reservoir to cause the device to dispense a dose of medicament.

Abstract: An apparatus enables concurrent restoration of a gastroesophageal valve and tightening of the lower esophageal sphincter. The apparatus comprises a longitudinal member having a distal end arranged to be received within a stomach, a tissue shaper at the distal end of the longitudinal member that forms a gastroesophageal valve from stomach tissue, and a tissue gatherer that gathers fundus tissue at or aboral to the gastroesophageal junction to reduce an esophageal opening into the stomach and tighten the lower esophageal sphincter. A fastener deployer then deploys at least one fastener pair to maintain both the restored gastroesophageal valve and the tightened lower esophageal sphincter.

Abstract: An infusion assembly comprises a disposable wearable infusion device having a body arranged to be adhered to a patient's skin and a cannula arranged to be received by the device body to deploy the cannula for delivering a medicament to beneath the patient's skin. A lock locks the cannula within the device body when the cannula is deployed in the device.

Abstract: A wearable infusion device comprises a reservoir that holds a liquid medicament, an outlet port that delivers the liquid medicament to a patient, a pump that displaces a volume of the liquid medicament to the outlet port when actuated, and a control that actuates the pump. The control is arranged to provide a perceptible indication that the pump has been actuated.

Abstract: A wearable infusion device prevents reservoir refilling. The device includes a base adapted to be adhered to a patient's skin, a reservoir that holds a liquid medicament, and a cannula that delivers liquid medicament from the reservoir to the patient. The device further includes a fill port communicating with the reservoir to permit the reservoir to be provided with the liquid medicament, and a lock-out that prevents the reservoir from being refilled through the fill port after the reservoir has been provided with the liquid medicament.

Abstract: A transoral gastroesophageal flap valve restoration device has sufficient flexibility and dimension to be passed through the mouth, throat, and esophagus of a patient into the patient's stomach. The device includes a first member and a second member hingedly coupled to the first member. The first and second members are configured to flex in a direction to follow the esophageal path into the stomach and to be substantially rigid when forming the restored gastroesophageal flap valve.

Abstract: A wearable infusion device comprises a reservoir, an outlet port, and a pump. The device further comprises a medicament level indicator including a non-elastic, non-compressible, elongated web fixed at one end with respect to the reservoir. The web is arranged to move with linear movement as the reservoir is filled and emptied.

Abstract: A wearable infusion device comprises a component that causes a piston to move an incremental distance to cause the device to dispense a dose of medicament from a reservoir.

Abstract: A wearable infusion device comprises a first control movable between a first position and a second position that when in the first position, establishes a first fluid path between a reservoir and a pump and when in the second position, establishes a second fluid path between the pump and an outlet. A second control actuates the pump only when the second fluid path has been established by the first control.

Abstract: A wearable infusion device comprises a reservoir that holds a liquid medicament, an outlet port that delivers the liquid medicament to a patient, a pump that delivers a volume of the liquid medicament from the reservoir to the outlet when actuated, and a tactile indicator representing the volume of the liquid medicament delivered to the outlet with each actuation of the pump.