Patents by Inventor Brett Monia

Brett Monia has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antisense modulation of matrix metalloproteinase 1 expression
    Publication number: 20060074043
    Abstract: Antisense compounds, compositions and methods are provided for modulating the expression of matrix metalloproteinase 1. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding matrix metalloproteinase 1. Methods of using these compounds for modulation of matrix metalloproteinase 1 expression and for treatment of diseases associated with expression of matrix metalloproteinase 1 are provided.
    Type: Application
    Filed: October 13, 2005
    Publication date: April 6, 2006
    Inventors: Brett Monia, Susan Freier, Sanjay Bhanot, Madeline Butler, Andrew Watt, Jacqueline Wyatt, Brenda Baker, Lex Cowsert, Kenneth Dobie
  • Enhanced antisense oligonucleotides
    Publication number: 20060063730
    Abstract: Described herein are gap-widened antisense oligonucleotides having improved therapeutic index as compared to 5-10-5 MOE gapmer antisense oligonucleotides of the same sequence. Also described are methods of reducing a target RNA in an animal using the gap-widened antisense oligonucleotides of the present invention. Further, are methods for selecting a gap-widened antisense oligonucleotides.
    Type: Application
    Filed: September 19, 2005
    Publication date: March 23, 2006
    Inventors: Brett Monia, Andrew Siwkowski, Sanjay Bhanot
  • Antisense modulation of c/ebp beta expression
    Publication number: 20060030045
    Abstract: Antisense compounds, compositions and methods are provided for modulating the expression of C/EBP beta. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding C/EBP beta. Methods of using these compounds for modulation of C/EBP beta expression and for treatment of diseases associated with expression of C/EBP beta are provided.
    Type: Application
    Filed: June 11, 2001
    Publication date: February 9, 2006
    Inventors: Brett Monia, Madeline Butler, Jacqueline Wyatt
  • Antisense modulation of PTP1B expression
    Publication number: 20060025372
    Abstract: Compounds, compositions and methods are provided for modulating the expression of PTP1B. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding PTP1B. Methods of using these compounds for modulation of PTP1B expression and for treatment of diseases associated with expression of PTP1B are provided.
    Type: Application
    Filed: August 1, 2005
    Publication date: February 2, 2006
    Inventors: Sanjay Bhanot, Lex Cowsert, Jacqueline Wyatt, Brett Monia, Madelline Butler, Robert McKay, Susan Freier, Kenneth Dobie
  • Antisense modulation of MEKK4 expression
    Publication number: 20060019920
    Abstract: Antisense compounds, compositions and methods are provided for modulating the expression of MEKK4. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding MEKK4. Methods of using these compounds for modulation of MEKK4 expression and for treatment of diseases associated with expression of MEKK4 are provided.
    Type: Application
    Filed: July 11, 2005
    Publication date: January 26, 2006
    Inventors: C. Bennett, Susan Freier, Brett Monia, Nicholas Dean, Hong Zhang, Robert McKay, Donna Ward, William Gaarde, Jacqueline Wyatt, Andrew Watt, Rosanne Crooke, Mark Graham, Pamela Nero, Kenneth Dobie, Alexander Borchers, Eric Marcusson, Mark Roach
  • Compositions and their uses directed to bone growth modulators
    Publication number: 20060003953
    Abstract: Disclosed herein are compounds, compositions and methods for modulating the expression of a bone growth modulator in a cell, tissue or animal. Also provided are methods of target validation. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders.
    Type: Application
    Filed: December 3, 2004
    Publication date: January 5, 2006
    Inventors: C. Bennett, Madeline Butler, Nicholas Dean, Kenneth Dobie, Joshua Finger, Ravi Jain, Robert McKay, Brett Monia, Kathleen Myers
  • Modulation of diacylglycerol acyltransferase 2 expression
    Publication number: 20050272680
    Abstract: Compounds, compositions and methods are provided for modulating the expression of diacylglycerol acyltransferase 2. The compositions comprise oligonucleotides, targeted to nucleic acid encoding diacylglycerol acyltransferase 2. Methods of using these compounds for modulation of diacylglycerol acyltransferase 2 expression and for diagnosis and treatment of diseases and conditions associated with expression of diacylglycerol acyltransferase 2 are provided.
    Type: Application
    Filed: February 24, 2005
    Publication date: December 8, 2005
    Inventors: Sanjay Bhanot, Kenneth Dobie, Xing-Xian Yu, Brett Monia
  • Antisense modulation of p70 S6 kinase expression
    Publication number: 20050267063
    Abstract: Antisense compounds, compositions and methods are provided for modulating the expression of p70 S6 kinase. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding p70 S6 kinase. Methods of using these compounds for modulation of p70 S6 kinase expression and for treatment of diseases associated with expression of p70 S6 kinase are provided.
    Type: Application
    Filed: April 27, 2005
    Publication date: December 1, 2005
    Inventors: C. Bennett, Brett Monia, Susan Freier, Brenda Baker, William Gaarde, Erich Koller, Susan Murray, Andrew Watt, Jacqueline Wyatt, Pamela Nero, Mark Roach, Lex Cowsert, Kenneth Dobie
  • Antisense modulation of TFAP2C expression
    Publication number: 20050227938
    Abstract: Antisense compounds, compositions and methods are provided for modulating the expression of TFAP2C. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding TFAP2C. Methods of using these compounds for modulation of TFAP2C expression and for treatment of diseases associated with expression of TFAP2C are provided.
    Type: Application
    Filed: December 17, 2004
    Publication date: October 13, 2005
    Inventors: C. Bennett, Brenda Baker, Nicholas Dean, Brett Monia, Susan Freier, James Karras, Hong Zhang, Susan Murray, Madeline Butler, Erich Koller, Thomas Condon, William Gaarde, Andrew Watt, Mark Graham, Jacqueline Wyatt, Lex Cowsert, Kenneth Dobie, Mark Roach
  • Modulation of kallikrein 6 expression
    Publication number: 20050227939
    Abstract: Compounds, compositions and methods are provided for modulating the expression of kallikrein 6. The compositions comprise oligonucleotides, targeted to nucleic acid encoding kallikrein 6. Methods of using these compounds for modulation of kallikrein 6 expression and for diagnosis and treatment of disease associated with expression of kallikrein 6 are provided.
    Type: Application
    Filed: January 14, 2005
    Publication date: October 13, 2005
    Inventors: C. Bennett, Brett Monia, Nicholas Dean, Sanjay Bhanot, Donna Ward, Lex Cowsert, Kenneth Dobie
  • Hepatocyte free uptake assays
    Publication number: 20050221275
    Abstract: The present invention provides methods of identifying oligomeric compounds, such as siRNA and double-stranded RNA compounds, having bioactivity in vivo, and kits.
    Type: Application
    Filed: April 14, 2004
    Publication date: October 6, 2005
    Inventors: C. Bennett, Robert McKay, Brett Monia, Brenda Baker, Namir Sioufi
  • Antisense modulation of thyroid hormone receptor interactor 6 expression
    Publication number: 20050222073
    Abstract: Antisense compounds, compositions and methods are provided for modulating the expression of thyroid hormone receptor interactor 6. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding thyroid hormone receptor interactor 6. Methods of using these compounds for modulation of thyroid hormone receptor interactor 6 expression and for treatment of diseases associated with expression of thyroid hormone receptor interactor 6 are provided.
    Type: Application
    Filed: March 2, 2005
    Publication date: October 6, 2005
    Inventors: C. Bennett, Brett Monia, Rosanne Crooke, Mark Graham, Susan Freier, Pamela Nero, Edward Wancewicz, Nicholas Dean, Lex Cowsert, Kenneth Dobie
  • Antisense modulation of sterol regulatory element-binding protein-1 expression
    Publication number: 20050215504
    Abstract: Antisense compounds, compositions and methods are provided for modulating the expression of sterol regulatory element-binding protein-1. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding sterol regulatory element-binding protein-1. Methods of using these compounds for modulation of sterol regulatory element-binding protein-1 expression and for treatment of diseases associated with expression of sterol regulatory element-binding protein-1 are provided.
    Type: Application
    Filed: December 16, 2004
    Publication date: September 29, 2005
    Inventors: C. Bennett, Susan Freier, Nicholas Dean, Brett Monia, William Gaarde, James Karras, Hong Zhang, Robert McKay, Donna Ward, Lex Cowsert, Erich Koller, Jacqueline Wyatt, Mark Roach, Andrew Watt, Brenda Baker, Kenneth Dobie
  • Antisense modulation of dual specific phosphatase 5 expression
    Publication number: 20050197309
    Abstract: Antisense compounds, compositions and methods are provided for modulating the expression of dual specific phosphatase 5. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding dual specific phosphatase 5. Methods of using these compounds for modulation of dual specific phosphatase 5 expression and for treatment of diseases associated with expression of dual specific phosphatase 5 are provided.
    Type: Application
    Filed: January 14, 2005
    Publication date: September 8, 2005
    Inventors: C. Bennett, Brett Monia, Susan Freier, Christopher Mirabelli, Ian Popoff, Jacqueline Wyatt, Andrew Watt, Kenneth Dobie
  • Modulation of SGLT2 expression
    Publication number: 20050191653
    Abstract: Compounds, compositions and methods are provided for modulating the expression of SGLT2. The compositions comprise oligonucleotides, targeted to nucleic acid encoding SGLT2. Methods of using these compounds for modulation of SGLT2 expression and for diagnosis and treatment of diseases and conditions associated with expression of SGLT2 are provided.
    Type: Application
    Filed: November 2, 2004
    Publication date: September 1, 2005
    Inventors: Susan Freier, Edward Wancewicz, Brett Monia, Andrew Siwkowski, Lynnetta Watts, Thomas Leedom
  • Compositions and their uses directed to cell growth and maintenance proteins
    Publication number: 20050186594
    Abstract: Antisense compounds, compositions and methods are provided for modulating the expression of G protein-coupled receptor kinase 6. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding G protein-coupled receptor kinase 6. Methods of using these compounds for modulation of G protein-coupled receptor kinase 6 expression and for treatment of diseases associated with expression of G protein-coupled receptor kinase 6 are provided.
    Type: Application
    Filed: December 17, 2004
    Publication date: August 25, 2005
    Inventors: C. Bennett, Susan Freier, Nicholas Dean, Ian Popoff, Brett Monia, Donna Ward, Ming-Yi Chiang, Ravi Jain, Kenneth Dobie
  • Modulation of eIF4E-BP1 expression
    Publication number: 20050181400
    Abstract: Compounds, compositions and methods are provided for modulating the expression of eIF4E-BP1. The compositions comprise oligonucleotides, targeted to nucleic acid encoding eIF4E-BP1. Methods of using these compounds for modulation of eIF4E-BP1 expression and for diagnosis and treatment of diseases and conditions associated with expression of eIF4E-BP1 are provided.
    Type: Application
    Filed: January 24, 2005
    Publication date: August 18, 2005
    Inventors: Brett Monia, Sanjay Bhanot, Kenneth Dobie, Ravi Jain
  • Compositions and their uses directed to binding proteins
    Publication number: 20050171042
    Abstract: Compounds, compositions and methods are provided for modulating the expression of Histone deacetylase 1. The compositions comprise oligonucleotides, targeted to nucleic acid encoding Histone deacetylase 1. Methods of using these compounds for modulation of Histone deacetylase 1 expression and for diagnosis and treatment of diseases and conditions associated with expression of Histone deacetylase 1 are provided.
    Type: Application
    Filed: October 29, 2004
    Publication date: August 4, 2005
    Inventors: Brett Monia, Jacqueline Wyatt
  • Compositions and their uses directed to metabolic proteins
    Publication number: 20050164254
    Abstract: Compounds, compositions and methods are provided for modulating the expression of adipophilin. The compositions comprise oligonucleotides, targeted to nucleic acid encoding adipophilin. Methods of using these compounds for modulation of adipophilin expression and for diagnosis and treatment of diseases and conditions associated with expression of adipophilin are provided.
    Type: Application
    Filed: December 9, 2004
    Publication date: July 28, 2005
    Inventors: C. Bennett, Brett Monia, Nicholas Dean, Susan Freier, Sanjay Bhanot, Donna Ward, Alexander Borchers, Tamara Sipes, Kenneth Dobie, Ravi Jain
  • Hepatocyte free uptake assays
    Publication number: 20050164209
    Abstract: The present invention provides methods of identifying an oligomeric compound having bioactivity in vivo, methods of identifying a small interfering RNA having bioactivity in vivo, and kits.
    Type: Application
    Filed: January 23, 2004
    Publication date: July 28, 2005
    Inventors: C. Bennett, Robert McKay, Brett Monia, Brenda Baker