Patents by Inventor Brett Neilan
Brett Neilan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11566271Abstract: The present invention relates to processes to make neosaxitoxin, and analogues and variants thereof, and intermediates in the production of neosaxitoxin in recombinant host cells. Neosaxitoxin and the analogues and variants thereof may be used in the production of pharmaceutical compositions.Type: GrantFiled: October 19, 2020Date of Patent: January 31, 2023Assignees: Vestlandets Innovasjonsseiskap AS, Newsouth Innovations Pty LimitedInventors: Ralf Kellmann, Brett Neilan
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Patent number: 11130784Abstract: The present invention relates generally to methods for producing microcystin and recombinant cells capable of producing microcystin. The recombinant cells express exogenous microcystin synthase polypeptides under the control of an exogenous promoter, and further express an exogenous phosphopantethienyl transferase (PPTase). The present invention further relates to microcystin as produced in recombinant cells by the methods described herein.Type: GrantFiled: October 17, 2017Date of Patent: September 28, 2021Assignee: NewSouth Innovations Pty LtdInventors: Brett Neilan, Tianzhe Liu, Rabia Mazmouz, Sarah Ongley
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Publication number: 20210108239Abstract: The present invention relates to processes to make neosaxitoxin, and analogues and variants thereof, and intermediates in the production of neosaxitoxin in recombinant host cells. Neosaxitoxin and the analogues and variants thereof may be used in the production of pharmaceutical compositions.Type: ApplicationFiled: October 19, 2020Publication date: April 15, 2021Inventors: Ralf Kellmann, Brett Neilan
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Patent number: 10947601Abstract: The invention generally relates to the field of saxitoxins and the identification of microorganisms capable of producing them. More specifically, the invention relates to the identification of genes encoding saxitoxin in dinoflagellates, and methods for the specific detection of dinoflagellates that are producers of saxitoxins.Type: GrantFiled: December 6, 2016Date of Patent: March 16, 2021Assignees: EWSOUTH INNOVATIONS PTY LIMITED, UNIVERSITETET I OSLOInventors: Brett A. Neilan, Shauna Ann Murray, Anke Stuken, Kjetill S. Jakobsen, Russel J. S. Orr, Ralf Kellmann
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Patent number: 10920256Abstract: The present invention relates to processes to make neosaxitoxin, and analogues and variants thereof, and intermediates in the production of neosaxitoxin in recombinant host cells. Neosaxitoxin and the analogues and variants thereof may be used in the production of pharmaceutical compositions.Type: GrantFiled: February 10, 2017Date of Patent: February 16, 2021Assignees: Vestlandets Innovasjonsseiskap AS, NEWSOUTH INNOVATIONS PTY LIMITEDInventors: Ralf Kellmann, Brett Neilan
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Patent number: 10415097Abstract: The present invention provides methods for the detection of cyanobacteria, and in particular, methods for the detection of cyanotoxic organisms. The invention further relates to methods of screening for compounds that modulate the activity of polynucleotides and/or polypeptides of the saxitoxin biosynthetic pathways.Type: GrantFiled: November 16, 2015Date of Patent: September 17, 2019Assignee: Newsouth Innovations PTY LimitedInventors: Brett A. Neilan, Troco Kaan Mihali, Ralf Kellmann, Young Jae Jeon
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Publication number: 20190263868Abstract: The present invention relates generally to methods for producing microcystin and recombinant cells capable of producing microcystin. The recombinant cells express exogenous microcystin synthase polypeptides under the control of an exogenous promoter, and further express an exogenous phosphopantethienyl transferase (PPTase). The present invention further relates to microcystin as produced in recombinant cells by the methods described herein.Type: ApplicationFiled: October 17, 2017Publication date: August 29, 2019Inventors: Brett Neilan, Tianzhe Liu, Rabia Mazmouz, Sarah Ongley
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Publication number: 20190048375Abstract: The present invention relates to processes to make neosaxitoxin, and analogues and variants thereof, and intermediates in the production of neosaxitoxin in recombinant host cells. Neosaxitoxin and the analogues and variants thereof may be used in the production of pharmaceutical compositions.Type: ApplicationFiled: February 10, 2017Publication date: February 14, 2019Applicants: Bergen Teknologioverføring AS, University of New South Wales Innovations, University of New South Wales InnovationsInventors: Ralf Kellmann, Brett Neilan
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Publication number: 20170081733Abstract: The invention generally relates to the field of saxitoxins and the identification of microorganisms capable of producing them. More specifically, the invention relates to the identification of genes encoding saxitoxin in dinoflagellates, and methods for the specific detection of dinoflagellates that are producers of saxitoxins.Type: ApplicationFiled: December 6, 2016Publication date: March 23, 2017Inventors: Brett A. Neilan, Shauna Ann Murray, Anke Stuken, Kjetill S. Jakobsen, Russel J. S. Orr, Ralf Kellmann
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Patent number: 9580759Abstract: The current disclosure generally relates to the field of saxitoxins and the identification of microorganisms capable of producing them. In particular, the saxitoxin A (sxtA) gene comprising catalytic domain sequences saxitoxin A1 (sxtA1) and saxitoxin A4 (sxtA4) is identified in a number of dinoflagellate species. The disclosure relates to methods of detection of saxitoxin-producing dinoflagellates by amplification and detection of the sxtA gene (in particular by PCR) and kits and primers for use in the method are also disclosed. Saxitoxin-producing dinoflagellate genera detected by the method include Alexandrium, Pyrodinium or Gymnodinium.Type: GrantFiled: May 16, 2012Date of Patent: February 28, 2017Assignees: UNIVERSITETET I OSLO, NEWSOUTH INNOVATIONS PTY LIMITEDInventors: Brett A. Neilan, Shauna Ann Murray, Anke Corinna Stüken, Kjetill S. Jakobsen, Russel J. S. Orr, Ralf Kellmann
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Publication number: 20160153030Abstract: The present invention provides methods for the detection of cyanobacteria, and in particular, methods for the detection of cyanotoxic organisms. The invention further relates to methods of screening for compounds that modulate the activity of polynucleotides and/or polypeptides of the saxitoxin biosynthetic pathways.Type: ApplicationFiled: November 16, 2015Publication date: June 2, 2016Inventors: Brett A. NEILAN, Troco Kaan MIHALI, Ralf KELLMANN, Young Jae JEON
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Patent number: 9115359Abstract: The invention relates to methods for producing secondary metabolites using transformed Synechocystis sp. bacteria, and secondary metabolites produced by transformed Synechocystis sp. bacteria. The invention further relates to phosphopantetheinyl transferase enzymes.Type: GrantFiled: April 2, 2008Date of Patent: August 25, 2015Assignee: NewSouth Innovations Pty LimitedInventors: Brett A. Neilan, Alex Roberts, Janine Copp
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Patent number: 8927217Abstract: The present invention relates to methods and kits for the detection of toxic cyanobacteria, in particular of hepatotoxin-producing cyanobacteria.Type: GrantFiled: May 31, 2006Date of Patent: January 6, 2015Assignee: NewSouth Innovations Pty LimitedInventors: Brett A. Neilan, Anne-Dorothee Jungblut
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Publication number: 20140113301Abstract: The current disclosure generally relates to the field of saxitoxins and the identification of microorganisms capable of producing them. In particular, the saxitoxin A (sxtA) gene comprising catalytic domain sequences saxitoxin A1 (sxtA1) and saxitoxin A4 (sxtA4) is identified in a number of dinoflagellate species. The disclosure relates to methods of detection of saxitoxin-producing dinoflagellates by amplification and detection of the sxtA gene (in particular by PCR) and kits and primers for use in the method are also disclosed. Saxitoxin-producing dinoflagellate genera detected by the method include Alexandrium, Pyrodinium or Gymnodinium.Type: ApplicationFiled: May 16, 2012Publication date: April 24, 2014Applicants: UNIVERSITETET I OSLO, NEWSOUTH INNOVATIONS PTY LIMITEDInventors: Brett A. Neilan, Shauna Ann Murray, Anke Stuken, Kjetill S. Jakobsen, Russel J. S. Orr, Ralf Kellmann
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Publication number: 20110129842Abstract: The present invention relates to methods for the detection of cyanobacteria, dinoflagellates, and in particular, methods for the detection of cyanotoxic organisms. Kits for the detection of cyanobacteria, dinoflagellates, and cyanotoxic organisms are provided. The invention further relates to methods of screening for compounds that modulate the activity of polynucleotides and/or polypeptides of the saxitoxin and cylindrospermopsin biosynthetic pathways.Type: ApplicationFiled: December 5, 2008Publication date: June 2, 2011Applicant: NEWSOUTH INNOVATIONS PTY LIMITEDInventors: Brett A. Neilan, Troco Kaan Mihali, Ralf Kellmann, Young Jae Jeon
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Publication number: 20100261218Abstract: The invention relates to methods for producing secondary metabolites using transformed Synechocystis sp. bacteria, and secondary metabolites produced by transformed Synechocystis sp. bacteria. The invention further relates to phosphopantetheinyl transferase enzymes.Type: ApplicationFiled: April 2, 2008Publication date: October 14, 2010Applicant: NEWSOUTH INNOVATIONS PTY LIMITEDInventors: Brett, A. Neilan, Alex Roberts, Janine Copp
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Publication number: 20090275018Abstract: The present invention relates to methods and kits for the detection of toxic cyanobacteria, in particular of hepatotoxin-producing cyanobacteria.Type: ApplicationFiled: May 31, 2006Publication date: November 5, 2009Applicant: New South Innovations PTY LimitedInventor: Brett Neilan