Abstract: RNA replicons encoding coronavirus S proteins, in particular SARS-CoV-2 S proteins, are described. Also described are pharmaceutical compositions and uses of the RNA replicons.

Abstract: RNA replicons encoding stabilized recombinant pre-fusion SARS CoV-2 S proteins are described. Also described are pharmaceutical compositions and uses of the RNA replicons.

Abstract: Bypass flow may be enabled for network traffic between devices. A source device may include a flow identifier in an outbound packet that is sent to a destination device. An inbound packed sent from the destination device may include information that describes a network path between the source device and the destination device. Subsequent outbound packets bound for the destination device may be rewritten based on the information describing the network path to bypass one or more network devices in the network path.

Abstract: Embodiments of the invention provide processes or methods of forming a sugar by exposing a starting mixture of ingredients including water, sucrose and inositol to a heat source until the ingredients in the mixture are evenly distributed in a product mixture. The product mixture is subsequently removed from the heat source, cooled and hardened. The hardened product mixture is crushed and pulverized to form a modified sugar with a glycemic index that is lower than at least one of the ingredients of the starting mixture of ingredients.

Abstract: Compositions and methods of treating a subject with cancer are described. The methods include administering to the subject a therapeutically effective amount of a pharmaceutical composition comprising a compound with the dual characteristics or restoring function of the c-Cbl ubiquitin ligase in cancer cells and in also worsening sublethal lysosomal dysfunction, preferably in combination with an agent capable of making cancer cells more oxidized. The pharmaceutical composition can be administered with an additional therapeutic agent or agents such as an agent that represents an accepted standard of care for the treatment of a particular type being treated. The methods can be used for treating a wide variety of different kinds of cancers, such as brain tumors, breast cancers, melanomas, breast cancers and lymphomas.

Abstract: Methods and compositions related to a novel cellular pathway, the redox/Fyn/c-Cbl pathway, include a variety of aspects. Provided herein are agents that selectively interrupt the pathway and methods of using the same. Also provided are screening methods used to identify a pro-oxidation toxicant or other agents and stimuli that affect the redox/Fyn/c-Cbl pathway. Methods of testing oxidation levels by evaluating aspects of the pathway are also provided.

Abstract: A method for determining a biomechanical property of a feed using infrared radiation to obtain spectral data on the feed. The spectral data is used to determine the biomechanical property based on the bond energies of the chemical constituents of the feed.